PMID- 30488433 OWN - NLM STAT- MEDLINE DCOM- 20200129 LR - 20200129 IS - 1541-0420 (Electronic) IS - 0006-341X (Linking) VI - 75 IP - 2 DP - 2019 Jun TI - Optimal design of multiple-objective Lot Quality Assurance Sampling (LQAS) plans. PG - 572-581 LID - 10.1111/biom.13008 [doi] AB - Lot Quality Assurance Sampling (LQAS) plans are widely used for health monitoring purposes. We propose a systematic approach to design multiple-objective LQAS plans that meet user-specified type 1 and 2 error rates and targets for selected diagnostic accuracy metrics. These metrics may include sensitivity, specificity, positive predictive value, and negative predictive value in high or low anticipated prevalence rate populations. We use Mixed Integer Nonlinear Programming (MINLP) tools to implement our design methodology. Our approach is flexible in that it can directly generate classic LQAS plans that control error rates only and find optimal LQAS plans that meet multiple objectives in terms of diagnostic metrics. We give examples, compare results with the classic LQAS and provide an application using a malaria outcome indicator survey in Mozambique. CI - (c) 2019 International Biometric Society. FAU - Duarte, Belmiro P M AU - Duarte BPM AUID- ORCID: 0000-0003-2550-4320 AD - Centro de Investigacao em Processos Quimicos e Produtos da Floresta, Department of Chemical Engineering, University of Coimbra, Polo II, R. Silvio Lima, 3030-790 Coimbra, Portugal. AD - Department of Chemical and Biological Engineering, ISEC, Polytechnic Institute of Coimbra, R. Pedro Nunes, 3030-199 Coimbra, Portugal. FAU - Wong, Weng Kee AU - Wong WK AUID- ORCID: 0000-0001-5568-3054 AD - Department of Biostatistics, Fielding School of Public Health, UCLA, 10833 Le Conte Ave., Los Angeles, California 90095-1772. LA - eng GR - R01 GM107639/GM/NIGMS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20190401 PL - England TA - Biometrics JT - Biometrics JID - 0370625 SB - IM MH - Computer Simulation MH - Diagnostic Errors MH - *Epidemiological Monitoring MH - Humans MH - Lot Quality Assurance Sampling/*methods MH - Malaria/diagnosis/epidemiology/therapy MH - Mozambique MH - Sampling Studies MH - Surveys and Questionnaires OTO - NOTNLM OT - Lot Quality Assurance Sampling OT - Mixed Integer Nonlinear Programming OT - diagnostic measures OT - disease monitoring programs OT - optimal design OT - public health policy EDAT- 2018/11/30 06:00 MHDA- 2020/01/30 06:00 CRDT- 2018/11/30 06:00 PHST- 2017/08/22 00:00 [received] PHST- 2018/11/14 00:00 [accepted] PHST- 2018/11/30 06:00 [pubmed] PHST- 2020/01/30 06:00 [medline] PHST- 2018/11/30 06:00 [entrez] AID - 10.1111/biom.13008 [doi] PST - ppublish SO - Biometrics. 2019 Jun;75(2):572-581. doi: 10.1111/biom.13008. Epub 2019 Apr 1.