PMID- 30488611
OWN - NLM
STAT- MEDLINE
DCOM- 20191112
LR  - 20191112
IS  - 1545-5017 (Electronic)
IS  - 1545-5009 (Linking)
VI  - 66
IP  - 3
DP  - 2019 Mar
TI  - Marked thrombocytopenia in a neonate is associated with anti-HPA-5b, 
      anti-HLA-A31, and anti-HLA-B55 antibodies.
PG  - e27555
LID - 10.1002/pbc.27555 [doi]
AB  - Maternal antibodies against human platelet antigen (HPA) and/or human leukocyte 
      antigen (HLA) cause fetal and neonatal alloimmune thrombocytopenia (FNAIT) in 
      0.09-0.15% of live births. Severe cases account for 5-31% and the frequency of 
      multiple kinds of alloantibodies is 6.9-9% of FNAIT. We present a case of severe 
      FNAIT associated with anti-HPA-5b, anti-HLA-A31, and anti-HLA-B55 antibodies, 
      successfully treated with immunoglobulin and platelet transfusion. The 
      anti-HLA-B55 antibody was detected in the newborn's serum, but disappeared on the 
      20th day, which was followed by an increase of the platelet count. These findings 
      suggested the potential involvement of an anti-HLA antibody in the pathogenesis 
      of FNAIT.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Okubo, Mitsuo
AU  - Okubo M
AUID- ORCID: 0000-0001-9098-4477
AD  - Department of Transfusion Service, Juntendo University Urayasu Hospital, Urayasu 
      City, Japan.
AD  - Department of Transfusion Medicine and Stem Cell Regulation, Juntendo University 
      Graduate School of Medicine, Tokyo, Japan.
FAU - Nishida, Eriko
AU  - Nishida E
AD  - Department of Pediatrics, Juntendo University Urayasu Hospital, Urayasu City, 
      Japan.
FAU - Watanabe, Akiko
AU  - Watanabe A
AD  - Department of Pediatrics, Juntendo University Urayasu Hospital, Urayasu City, 
      Japan.
FAU - Nishizaki, Naoto
AU  - Nishizaki N
AD  - Department of Pediatrics, Juntendo University Urayasu Hospital, Urayasu City, 
      Japan.
FAU - Obinata, Kaoru
AU  - Obinata K
AD  - Department of Pediatrics, Juntendo University Urayasu Hospital, Urayasu City, 
      Japan.
FAU - Azuma, Fumihiro
AU  - Azuma F
AD  - Laboratory Department, Kanto-Koshinetsu Block Blood Center, Japanese Red Cross, 
      Tokyo, Japan.
FAU - Matsuhashi, Mika
AU  - Matsuhashi M
AD  - Laboratory Department, Kanto-Koshinetsu Block Blood Center, Japanese Red Cross, 
      Tokyo, Japan.
FAU - Watanabe-Okochi, Naoko
AU  - Watanabe-Okochi N
AD  - Laboratory Department, Kanto-Koshinetsu Block Blood Center, Japanese Red Cross, 
      Tokyo, Japan.
FAU - Tsuno, Nelson Hirokazu
AU  - Tsuno NH
AD  - Laboratory Department, Kanto-Koshinetsu Block Blood Center, Japanese Red Cross, 
      Tokyo, Japan.
FAU - Miyake, Kazunori
AU  - Miyake K
AD  - Department of Laboratory Medicine, Juntendo University Urayasu Hospital, Urayasu 
      City, Japan.
FAU - Yamaguchi, Minoru
AU  - Yamaguchi M
AD  - Yamaguchi Hospital, Funabashi City, Japan.
FAU - Yoshida, Koyo
AU  - Yoshida K
AD  - Department of Obstetrics and Gynecology, Juntendo University Urayasu Hospital, 
      Urayasu City, Japan.
FAU - Ohsaka, Akimichi
AU  - Ohsaka A
AD  - Department of Transfusion Medicine and Stem Cell Regulation, Juntendo University 
      Graduate School of Medicine, Tokyo, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20181128
PL  - United States
TA  - Pediatr Blood Cancer
JT  - Pediatric blood & cancer
JID - 101186624
RN  - 0 (Antigens, Human Platelet)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A31 antigen)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B55 antigen)
RN  - 0 (Immunoglobulins)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Adult
MH  - Antigens, Human Platelet/*immunology
MH  - Female
MH  - HLA-A Antigens/*immunology
MH  - HLA-B Antigens/*immunology
MH  - Humans
MH  - Immunity, Maternally-Acquired/*immunology
MH  - Immunoglobulins/administration & dosage
MH  - Infant, Newborn
MH  - Isoantibodies/*immunology
MH  - Male
MH  - Platelet Transfusion/methods
MH  - Prognosis
MH  - Thrombocytopenia, Neonatal Alloimmune/*immunology/pathology/therapy
OTO - NOTNLM
OT  - HLA
OT  - fetal and neonatal alloimmune thrombocytopenia
OT  - human platelet antigen
OT  - thrombocytopenia
EDAT- 2018/11/30 06:00
MHDA- 2019/11/13 06:00
CRDT- 2018/11/30 06:00
PHST- 2018/08/09 00:00 [received]
PHST- 2018/10/03 00:00 [revised]
PHST- 2018/10/25 00:00 [accepted]
PHST- 2018/11/30 06:00 [pubmed]
PHST- 2019/11/13 06:00 [medline]
PHST- 2018/11/30 06:00 [entrez]
AID - 10.1002/pbc.27555 [doi]
PST - ppublish
SO  - Pediatr Blood Cancer. 2019 Mar;66(3):e27555. doi: 10.1002/pbc.27555. Epub 2018 
      Nov 28.