PMID- 30498573
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 2055-7647 (Print)
IS  - 2055-7647 (Electronic)
IS  - 2055-7647 (Linking)
VI  - 4
IP  - 1
DP  - 2018
TI  - Myocardial remodelling and tissue characterisation by cardiovascular magnetic 
      resonance (CMR) in endurance athletes.
PG  - e000422
LID - 10.1136/bmjsem-2018-000422 [doi]
LID - e000422
AB  - There is still some controversy about the benignity of structural changes 
      observed in athlete's heart, especially regarding the observation of increased 
      biomarkers and the presence of myocardial fibrosis (MF). AIM: Our purpose was to 
      evaluate by cardiovascular magnetic resonance (CMR) the presence of diffuse as 
      well as focal MF in a series of high-performance veteran endurance athletes. 
      METHODS: Thirty-four veteran healthy male endurance athletes, still being in 
      regular training, with more than 10 years of training underwent a CMR. A 
      cardiopulmonary exercise test was also performed to assess their maximal physical 
      performance. The control group consisted in 12 non-trained normal individuals. 
      RESULTS: We found an increase in both, right and left ventricular (LV) volumes in 
      the athlete's group when compared with controls. There was no increase in indexed 
      LV myocardial mass despite of a significantly increased maximal myocardial wall 
      thickness in comparison to controls. Native T1 values and extracellular volume 
      (ECV) were normal in all cases. We did not find differences in native T1 values 
      and ECV between both groups. In three athletes (9%), non-ischaemic late 
      gadolinium enhancement (LGE) was observed. We did not find a correlation between 
      total training volume and presence of LGE or with the ECV value. CONCLUSIONS: Our 
      results show that the majority of veteran endurance athletes present with 
      myocardial remodelling without MF as a physiological adaptive phenomenon. In the 
      only three athletes with focal MF, the LGE pattern observed suggests an 
      intercurrent event not related with the remodelling phenomenon.
FAU - Pujadas, Sandra
AU  - Pujadas S
AD  - Cardiac Imaging Unit, Cardiology Department, Hospital de la Santa Creu i Sant 
      Pau, Autonomous University of Barcelona, Barcelona, Spain.
AD  - Radiology Department, Clinica Creu Blanca, Barcelona, Spain.
FAU - Donate, Maite
AU  - Donate M
AD  - Cardiac Imaging Unit, Cardiology Department, Hospital de la Santa Creu i Sant 
      Pau, Autonomous University of Barcelona, Barcelona, Spain.
FAU - Li, Chi-Hion
AU  - Li CH
AD  - Cardiac Imaging Unit, Cardiology Department, Hospital de la Santa Creu i Sant 
      Pau, Autonomous University of Barcelona, Barcelona, Spain.
AD  - Radiology Department, Clinica Creu Blanca, Barcelona, Spain.
FAU - Merchan, Soraya
AU  - Merchan S
AD  - Cardiac Imaging Unit, Cardiology Department, Hospital de la Santa Creu i Sant 
      Pau, Autonomous University of Barcelona, Barcelona, Spain.
FAU - Cabanillas, Ana
AU  - Cabanillas A
AD  - Radiology Department, Clinica Creu Blanca, Barcelona, Spain.
FAU - Alomar, Xavier
AU  - Alomar X
AD  - Radiology Department, Clinica Creu Blanca, Barcelona, Spain.
FAU - Pons-Llado, Guillem
AU  - Pons-Llado G
AD  - Cardiac Imaging Unit, Cardiology Department, Hospital de la Santa Creu i Sant 
      Pau, Autonomous University of Barcelona, Barcelona, Spain.
AD  - Radiology Department, Clinica Creu Blanca, Barcelona, Spain.
FAU - Serra-Grima, Ricard
AU  - Serra-Grima R
AD  - Cardiac Imaging Unit, Cardiology Department, Hospital de la Santa Creu i Sant 
      Pau, Autonomous University of Barcelona, Barcelona, Spain.
FAU - Carreras, Francesc
AU  - Carreras F
AD  - Cardiac Imaging Unit, Cardiology Department, Hospital de la Santa Creu i Sant 
      Pau, Autonomous University of Barcelona, Barcelona, Spain.
AD  - Radiology Department, Clinica Creu Blanca, Barcelona, Spain.
LA  - eng
PT  - Journal Article
DEP - 20181025
PL  - England
TA  - BMJ Open Sport Exerc Med
JT  - BMJ open sport & exercise medicine
JID - 101681007
PMC - PMC6241997
OTO - NOTNLM
OT  - athlete
OT  - heart
OT  - radiology
OT  - running
COIS- Competing interests: None declared.
EDAT- 2018/12/01 06:00
MHDA- 2018/12/01 06:01
PMCR- 2018/10/25
CRDT- 2018/12/01 06:00
PHST- 2018/10/03 00:00 [accepted]
PHST- 2018/12/01 06:00 [entrez]
PHST- 2018/12/01 06:00 [pubmed]
PHST- 2018/12/01 06:01 [medline]
PHST- 2018/10/25 00:00 [pmc-release]
AID - bmjsem-2018-000422 [pii]
AID - 10.1136/bmjsem-2018-000422 [doi]
PST - epublish
SO  - BMJ Open Sport Exerc Med. 2018 Oct 25;4(1):e000422. doi: 
      10.1136/bmjsem-2018-000422. eCollection 2018.