PMID- 30498726
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 2305-5839 (Print)
IS  - 2305-5847 (Electronic)
IS  - 2305-5839 (Linking)
VI  - 6
IP  - 20
DP  - 2018 Oct
TI  - Low prevalence of rheumatoid arthritis among patients with pre-existing type 2 
      diabetes mellitus.
PG  - 399
LID - 10.21037/atm.2018.09.14 [doi]
LID - 399
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is a non-autoimmune disease 
      characterized by chronic hyperglycemia and increased non-enzymatic glycation of 
      amino groups. Glycation occurs through a series of events eventually leading to 
      the formation of irreversible "advanced glycation end-products" (AGEs). AGEs may 
      affect the function of long-lived proteins, including cytokines, immunoglobulins 
      and their receptors, resulting in a "less active" immune system. We aimed to test 
      the hypothesis that a common inflammatory chronic disease, such as rheumatoid 
      arthritis (RA), in which the earliest event is an inflammatory response to 
      unknown stimulus, has a lower prevalence in these patients than in normoglycemic, 
      non-diabetic subjects. METHODS: In this study, we compared the prevalence of RA 
      in a prospectively followed outpatient cohort of patients with T2DM patients 
      (n=1,630) with a control, matched, non-diabetic population (n=1,630). RESULTS: 
      Among non-diabetic controls, 13 patients (prevalence 0.80%) with RA were 
      identified. An almost 3-fold lower prevalence of RA (0.25%) was found in 
      consecutive patients with T2DM (P=0.029). Most of the RA cases among participants 
      with T2DM were diagnosed early after diabetes onset. The onset of RA in patients 
      with T2DM occurred at significantly older age (64+/-15 years) as compared to the 
      non-diabetes group (48+/-18 years; P=0.004). CONCLUSIONS: The prevalence of RA is 
      lower and occurs in an older age in patients with pre-existing T2DM in comparison 
      with people without T2DM.
FAU - Tentolouris, Anastasios
AU  - Tentolouris A
AD  - First Department of Propaedeutic Internal Medicine, National and Kapodistrian 
      University of Athens, Laiko General Hospital, Athens, Greece.
FAU - Thanopoulou, Anastasia
AU  - Thanopoulou A
AD  - Second Department of Internal Medicine, National and Kapodistrian University of 
      Athens, Hippokration Hospital, Athens, Greece.
FAU - Tentolouris, Nikolaos
AU  - Tentolouris N
AD  - First Department of Propaedeutic Internal Medicine, National and Kapodistrian 
      University of Athens, Laiko General Hospital, Athens, Greece.
FAU - Eleftheriadou, Ioanna
AU  - Eleftheriadou I
AD  - First Department of Propaedeutic Internal Medicine, National and Kapodistrian 
      University of Athens, Laiko General Hospital, Athens, Greece.
FAU - Voulgari, Christina
AU  - Voulgari C
AD  - First Department of Propaedeutic Internal Medicine, National and Kapodistrian 
      University of Athens, Laiko General Hospital, Athens, Greece.
FAU - Andrianakos, Alexandros
AU  - Andrianakos A
AD  - Rheumatic Disease Epidemiology Section, Hellenic Foundation for Rheumatological 
      Research, Athens, Greece.
FAU - Sfikakis, Petros P
AU  - Sfikakis PP
AD  - First Department of Propaedeutic Internal Medicine, National and Kapodistrian 
      University of Athens, Laiko General Hospital, Athens, Greece.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Transl Med
JT  - Annals of translational medicine
JID - 101617978
PMC - PMC6230853
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - prevalence
OT  - rheumatoid arthritis (RA)
COIS- Conflicts of Interest: The authors have no conflicts of interest to declare.
EDAT- 2018/12/01 06:00
MHDA- 2018/12/01 06:01
PMCR- 2018/10/01
CRDT- 2018/12/01 06:00
PHST- 2018/12/01 06:00 [entrez]
PHST- 2018/12/01 06:00 [pubmed]
PHST- 2018/12/01 06:01 [medline]
PHST- 2018/10/01 00:00 [pmc-release]
AID - atm-06-20-399 [pii]
AID - 10.21037/atm.2018.09.14 [doi]
PST - ppublish
SO  - Ann Transl Med. 2018 Oct;6(20):399. doi: 10.21037/atm.2018.09.14.