PMID- 30499140
OWN - NLM
STAT- MEDLINE
DCOM- 20200326
LR  - 20200326
IS  - 1741-4520 (Electronic)
IS  - 0914-3505 (Linking)
VI  - 59
IP  - 6
DP  - 2019 Nov
TI  - Induction of a thoracolumbar supernumerary rib in rat developmental toxicity 
      studies: A short discussion on the critical window.
PG  - 190-192
LID - 10.1111/cga.12320 [doi]
AB  - Thoracolumbar supernumerary ribs (TSRs) are classified as less severe skeletal 
      anomalies in rat developmental toxicity studies, although their incidence is 
      relatively high in rodent studies. To investigate the characteristics of the 
      critical window for chemically-induced TSR, in this study, rats were administered 
      5-fluorocytocine (5-FC) or sodium salicylate (SAL) at one of three time periods 
      on gestational day (GD) 9, early morning (7:00 am), midday (12:00 pm to 1:00 pm), 
      or late afternoon (4:00 pm or 7:00 pm). The incidence of TSR and other anomalies 
      were assessed in GD20 fetuses. A single treatment with both chemicals on 
      GD9-induced TSR, with the incidence highest when administered at 7:00 Am, 
      decreasing gradually when administered later. This trajectory was clearer in rats 
      treated with 5-FC than with SAL. The critical period of TSR induction is shorter 
      in rats administered 5-FC than SAL. The characteristics of the critical window 
      may cause variability in the incidence of TSR observed in developmental toxicity 
      studies.
CI  - (c) 2018 Japanese Teratology Society.
FAU - Kuwagata, Makiko
AU  - Kuwagata M
AUID- ORCID: 0000-0003-2801-444X
AD  - Laboratory of Safety Evaluation, Division of Safety, Hatano Research Institute, 
      Food and Drug Safety Center, Hadano, Japan.
FAU - Senuma, Mika
AU  - Senuma M
AD  - Laboratory of Safety Evaluation, Division of Safety, Hatano Research Institute, 
      Food and Drug Safety Center, Hadano, Japan.
FAU - Todoroki, Mai
AU  - Todoroki M
AD  - Laboratory of Safety Evaluation, Division of Safety, Hatano Research Institute, 
      Food and Drug Safety Center, Hadano, Japan.
FAU - Kumagai, Fumiaki
AU  - Kumagai F
AD  - Laboratory of Safety Evaluation, Division of Safety, Hatano Research Institute, 
      Food and Drug Safety Center, Hadano, Japan.
FAU - Kumamoto, Takayuki
AU  - Kumamoto T
AD  - School of Pharmaceutical Sciences, Ohu University, Koriyama, Japan.
FAU - Ogawa, Tetsuo
AU  - Ogawa T
AD  - Faculty of Medicine, Saitama Medical University, Saitama, Japan.
LA  - eng
GR  - 1607/Food Safety Commission, Cabinet Office, Government of Japan (Research 
      Program for Risk Assessment Study on Food Safety, No 1607)/
PT  - Journal Article
DEP - 20181214
PL  - Australia
TA  - Congenit Anom (Kyoto)
JT  - Congenital anomalies
JID - 9306292
RN  - 0 (Teratogens)
RN  - D83282DT06 (Flucytosine)
RN  - WIQ1H85SYP (Sodium Salicylate)
SB  - IM
MH  - Abnormalities, Drug-Induced/*physiopathology
MH  - Animals
MH  - Fetus/drug effects/*physiopathology
MH  - Flucytosine/toxicity
MH  - Humans
MH  - Musculoskeletal Abnormalities/chemically induced/*physiopathology
MH  - Rats
MH  - Ribs/growth & development/*physiopathology
MH  - Sodium Salicylate/toxicity
MH  - Teratogens/pharmacology/toxicity
OTO - NOTNLM
OT  - 5-fluocytocine
OT  - critical period
OT  - rats
OT  - sodium salicylate
OT  - thoracolumbar supernumerary rib
EDAT- 2018/12/01 06:00
MHDA- 2020/03/27 06:00
CRDT- 2018/12/01 06:00
PHST- 2018/08/03 00:00 [received]
PHST- 2018/11/18 00:00 [revised]
PHST- 2018/11/21 00:00 [accepted]
PHST- 2018/12/01 06:00 [pubmed]
PHST- 2020/03/27 06:00 [medline]
PHST- 2018/12/01 06:00 [entrez]
AID - 10.1111/cga.12320 [doi]
PST - ppublish
SO  - Congenit Anom (Kyoto). 2019 Nov;59(6):190-192. doi: 10.1111/cga.12320. Epub 2018 
      Dec 14.