PMID- 3049949
OWN - NLM
STAT- MEDLINE
DCOM- 19881114
LR  - 20170210
IS  - 0732-183X (Print)
IS  - 0732-183X (Linking)
VI  - 6
IP  - 10
DP  - 1988 Oct
TI  - A comparison of marrow transplantation with chemotherapy for adults with acute 
      leukemia of poor prognosis in first complete remission.
PG  - 1548-57
AB  - From July 1980 to November 1985, 109 patients with acute myelogenous and 
      lymphoblastic leukemia who had reached a complete remission (CR) following 
      induction treatment were assigned to a study comparing marrow transplantation 
      with chemotherapy as a postremission treatment. Sixty-nine patients did not have 
      a human leukocyte antigen (HLA)-identical donor, and therefore served as 
      chemotherapy controls; 40 patients had HLA-identical donors, and therefore were 
      assigned to the transplant arm. Of these, 23 were transplanted in first remission 
      and 17 were not. Ten of these 17 were subsequently transplanted in relapse. 
      Initially, only patients with poor prognosis determined by a predictive model 
      were entered into the study. Subsequently, patients with moderately poor 
      prognosis were admitted. Comparing the chemotherapy group with the patients 
      transplanted in first CR, significant control of leukemia relapse in transplanted 
      patients was seen in the subgroup with acute myelogenous leukemia (AML) (P less 
      than .1), and acute lymphoblastic leukemia (ALL) (P less than .01), in the poor 
      (P = .01) and intermediate subgroup (P = .01), and in the good-prognostic groups 
      (P = .05). The survival was affected significantly in only the poor and 
      intermediate subgroups. The use of predictive models might help to select 
      patients for whom bone marrow transplantation is appropriate in first remission 
      and those for whom bone marrow transplantation can be left as the initial 
      treatment of relapse. Predictive models could further be helpful in comparing 
      studies performed at different transplant centers.
FAU - Zander, A R
AU  - Zander AR
AD  - Department of Hematology, University of Texas M.D. Anderson Hospital and Tumor 
      Institute, Houston.
FAU - Keating, M
AU  - Keating M
FAU - Dicke, K
AU  - Dicke K
FAU - Dixon, D
AU  - Dixon D
FAU - Pierce, S
AU  - Pierce S
FAU - Jagannath, S
AU  - Jagannath S
FAU - Peters, L
AU  - Peters L
FAU - Horwitz, L
AU  - Horwitz L
FAU - Cockerill, K
AU  - Cockerill K
FAU - Spitzer, G
AU  - Spitzer G
AU  - et al.
LA  - eng
GR  - CA-23077/CA/NCI NIH HHS/United States
GR  - CA-28153/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Oncol
JT  - Journal of clinical oncology : official journal of the American Society of 
      Clinical Oncology
JID - 8309333
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - *Bone Marrow Transplantation
MH  - Female
MH  - Graft vs Host Disease
MH  - Humans
MH  - Leukemia, Myeloid, Acute/drug therapy/*surgery
MH  - Male
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy/*surgery
MH  - Prognosis
MH  - Prospective Studies
MH  - Remission Induction
EDAT- 1988/10/01 00:00
MHDA- 1988/10/01 00:01
CRDT- 1988/10/01 00:00
PHST- 1988/10/01 00:00 [pubmed]
PHST- 1988/10/01 00:01 [medline]
PHST- 1988/10/01 00:00 [entrez]
AID - 10.1200/JCO.1988.6.10.1548 [doi]
PST - ppublish
SO  - J Clin Oncol. 1988 Oct;6(10):1548-57. doi: 10.1200/JCO.1988.6.10.1548.