PMID- 30500995
OWN - NLM
STAT- MEDLINE
DCOM- 20200804
LR  - 20230124
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 19
IP  - 5
DP  - 2019 May
TI  - UVB-induced depletion of donor-derived dendritic cells prevents allograft 
      rejection of immune-privileged hair follicles in humanized mice.
PG  - 1344-1355
LID - 10.1111/ajt.15207 [doi]
AB  - Dendritic cells (DCs) are key targets for immunity and tolerance induction; they 
      present donor antigens to recipient T cells by donor- and recipient-derived 
      pathways. Donor-derived DCs, which are critical during the acute posttransplant 
      period, can be depleted in graft tissue by forced migration via ultraviolet B 
      light (UVB) irradiation. Here, we investigated the tolerogenic potential of 
      donor-derived DC depletion through in vivo and ex vivo UVB preirradiation (UV) 
      combined with the injection of anti-CD154 antibody (Ab) into recipients in an 
      MHC-mismatched hair follicle (HF) allograft model in humanized mice. 
      Surprisingly, human HF allografts achieved long-term survival with newly growing 
      pigmented hair shafts in both Ab-treated groups (Ab-only and UV plus Ab) and in 
      the UV-only group, whereas the control mice rejected all HF allografts with no 
      hair regrowth. Perifollicular human CD3(+) T cell and MHC class II(+) cell 
      infiltration was significantly diminished in the presence of UV and/or Ab 
      treatment. HF allografts in the UV-only group showed stable maintenance of the 
      immune privilege in the HF epithelium without evidence of antigen-specific T cell 
      tolerance, which is likely promoted by normal HFs in vivo. This immunomodulatory 
      strategy targeting the donor tissue exhibited novel biological relevance for 
      clinical allogeneic transplantation without generalized immunosuppression.
CI  - (c) 2018 The American Society of Transplantation and the American Society of 
      Transplant Surgeons.
FAU - Kim, Jin Yong
AU  - Kim JY
AUID- ORCID: 0000-0002-2069-4009
AD  - Department of Dermatology, Seoul National University College of Medicine, Seoul, 
      Korea.
AD  - Institute of Human-Environment Interface Biology, Medical Research Center, Seoul 
      National University, Seoul, Korea.
AD  - Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute, 
      Seoul National University Hospital, Seoul, Korea.
FAU - Kang, Bo Mi
AU  - Kang BM
AD  - Department of Dermatology, Seoul National University College of Medicine, Seoul, 
      Korea.
AD  - Institute of Human-Environment Interface Biology, Medical Research Center, Seoul 
      National University, Seoul, Korea.
AD  - Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute, 
      Seoul National University Hospital, Seoul, Korea.
FAU - Lee, Ji Su
AU  - Lee JS
AD  - Department of Dermatology, Seoul National University College of Medicine, Seoul, 
      Korea.
AD  - Institute of Human-Environment Interface Biology, Medical Research Center, Seoul 
      National University, Seoul, Korea.
AD  - Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute, 
      Seoul National University Hospital, Seoul, Korea.
FAU - Park, Hi-Jung
AU  - Park HJ
AD  - Transplantation Research Institute, Medical Research Center, Seoul National 
      University College of Medicine, Seoul, Korea.
AD  - Department of Pathology and Graduate Course of Translational Medicine, Seoul 
      National University College of Medicine, Seoul, Korea.
FAU - Wi, Hae Joo
AU  - Wi HJ
AD  - Transplantation Research Institute, Medical Research Center, Seoul National 
      University College of Medicine, Seoul, Korea.
AD  - Department of Pathology and Graduate Course of Translational Medicine, Seoul 
      National University College of Medicine, Seoul, Korea.
FAU - Yoon, Ji-Seon
AU  - Yoon JS
AD  - Institute of Human-Environment Interface Biology, Medical Research Center, Seoul 
      National University, Seoul, Korea.
AD  - Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute, 
      Seoul National University Hospital, Seoul, Korea.
FAU - Ahn, Curie
AU  - Ahn C
AD  - Transplantation Research Institute, Medical Research Center, Seoul National 
      University College of Medicine, Seoul, Korea.
AD  - Department of Internal Medicine, Seoul National University College of Medicine; 
      Transplantation Center, Seoul National University Hospital, Seoul, Korea.
FAU - Shin, Sue
AU  - Shin S
AD  - Department of Laboratory Medicine, Seoul National University College of Medicine, 
      Seoul, Korea.
AD  - Department of Laboratory Medicine, Boramae Hospital, Seoul, Korea.
AD  - Seoul Metropolitan Government Public Cord Blood Bank, Seoul, Korea.
FAU - Kim, Kyu Han
AU  - Kim KH
AD  - Department of Dermatology, Seoul National University College of Medicine, Seoul, 
      Korea.
AD  - Institute of Human-Environment Interface Biology, Medical Research Center, Seoul 
      National University, Seoul, Korea.
AD  - Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute, 
      Seoul National University Hospital, Seoul, Korea.
FAU - Jung, Kyeong Cheon
AU  - Jung KC
AD  - Transplantation Research Institute, Medical Research Center, Seoul National 
      University College of Medicine, Seoul, Korea.
AD  - Department of Pathology and Graduate Course of Translational Medicine, Seoul 
      National University College of Medicine, Seoul, Korea.
FAU - Kwon, Ohsang
AU  - Kwon O
AUID- ORCID: 0000-0003-0464-5124
AD  - Department of Dermatology, Seoul National University College of Medicine, Seoul, 
      Korea.
AD  - Institute of Human-Environment Interface Biology, Medical Research Center, Seoul 
      National University, Seoul, Korea.
AD  - Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute, 
      Seoul National University Hospital, Seoul, Korea.
LA  - eng
GR  - HI13C1853/Korea Health Industry Development Institute (KHIDI)/International
GR  - 0320160070 (2016-1032)/Seoul National University Hospital (SNUH) Research 
      Fund/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181228
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of 
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology/radiation effects
MH  - Graft Rejection/etiology/immunology/*prevention & control
MH  - Graft Survival/*immunology/radiation effects
MH  - Hair Follicle/*growth & development/immunology/radiation effects
MH  - Humans
MH  - Immune Tolerance/*immunology/radiation effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred NOD
MH  - Mice, SCID
MH  - *Tissue Donors
MH  - Transplantation, Homologous
MH  - *Ultraviolet Rays
OTO - NOTNLM
OT  - basic (laboratory) research/science
OT  - dendritic cell
OT  - dermatology
OT  - experimental
OT  - immunosuppression/immune modulation
OT  - stem cells
OT  - tissue (nonvascularized) transplantation
OT  - tolerance
OT  - translational research/science
EDAT- 2018/12/01 06:00
MHDA- 2020/08/05 06:00
CRDT- 2018/12/01 06:00
PHST- 2018/09/04 00:00 [received]
PHST- 2018/11/23 00:00 [revised]
PHST- 2018/11/23 00:00 [accepted]
PHST- 2018/12/01 06:00 [pubmed]
PHST- 2020/08/05 06:00 [medline]
PHST- 2018/12/01 06:00 [entrez]
AID - S1600-6135(22)09069-4 [pii]
AID - 10.1111/ajt.15207 [doi]
PST - ppublish
SO  - Am J Transplant. 2019 May;19(5):1344-1355. doi: 10.1111/ajt.15207. Epub 2018 Dec 
      28.