PMID- 30501044
OWN - NLM
STAT- MEDLINE
DCOM- 20190418
LR  - 20231213
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 15
IP  - 12
DP  - 2018 Nov 29
TI  - Biomarkers of Exposure to Secondhand and Thirdhand Tobacco Smoke: Recent Advances 
      and Future Perspectives.
LID - 10.3390/ijerph15122693 [doi]
LID - 2693
AB  - Smoking is the leading preventable disease worldwide and passive smoking is 
      estimated to be the cause of about 1.0% of worldwide mortality. The determination 
      of tobacco smoke biomarkers in human biological matrices is key to assess the 
      health effects related to the exposure to environmental tobacco smoke. The 
      biomonitoring of cotinine, the main nicotine metabolite, in human 
      biofluids-including urine, serum or saliva-has been extensively used to assess 
      this exposure. However, the simultaneous determination of cotinine together with 
      other tobacco biomarkers and the selection of alternative biological matrices, 
      such as hair, skin or exhaled breath, would enable a better characterization of 
      the kind and extent of tobacco exposure. This review aims to perform a critical 
      analysis of the up-to-date literature focused on the simultaneous determination 
      of multiple tobacco smoke biomarkers studied in different biological matrices, 
      due to the exposure to secondhand smoke (SHS) and thirdhand smoke (THS). Target 
      biomarkers included both tobacco-specific biomarkers-nicotine and tobacco 
      specific nitrosamine biomarkers-and tobacco-related biomarkers, such as those 
      from polycyclic aromatic hydrocarbons, volatile organic compounds, metals and 
      carbon monoxide. To conclude, we discuss the suitability of determining multiple 
      biomarkers through several relevant examples of SHS and THS exposure.
FAU - Torres, Sonia
AU  - Torres S
AUID- ORCID: 0000-0001-8881-0793
AD  - Department of Electronic Engineering, Universitat Rovira i Virgili, Paisos 
      Catalans 26, 43007 Tarragona, Spain. sonia.torres@urv.cat.
FAU - Merino, Carla
AU  - Merino C
AUID- ORCID: 0000-0002-8793-5516
AD  - Department of Electronic Engineering, Universitat Rovira i Virgili, Paisos 
      Catalans 26, 43007 Tarragona, Spain. carlamelissa.merino@urv.cat.
FAU - Paton, Beatrix
AU  - Paton B
AUID- ORCID: 0000-0001-5896-5495
AD  - Department of Electronic Engineering, Universitat Rovira i Virgili, Paisos 
      Catalans 26, 43007 Tarragona, Spain. beatrix.paton@urv.cat.
FAU - Correig, Xavier
AU  - Correig X
AUID- ORCID: 0000-0002-6902-3054
AD  - Department of Electronic Engineering, Universitat Rovira i Virgili, Paisos 
      Catalans 26, 43007 Tarragona, Spain. xavier.correig@urv.cat.
AD  - Institut d'Investigacio Sanitaria Pere Virgili, Escorxador s/n, 43003 Tarragona, 
      Spain. xavier.correig@urv.cat.
AD  - CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic 
      Disorders, Carlos III Health Institute, Monforte de Lemos 3-5, 28029 Madrid, 
      Spain. xavier.correig@urv.cat.
FAU - Ramirez, Noelia
AU  - Ramirez N
AUID- ORCID: 0000-0002-9251-0790
AD  - Department of Electronic Engineering, Universitat Rovira i Virgili, Paisos 
      Catalans 26, 43007 Tarragona, Spain. noelia.ramirez@urv.cat.
AD  - Institut d'Investigacio Sanitaria Pere Virgili, Escorxador s/n, 43003 Tarragona, 
      Spain. noelia.ramirez@urv.cat.
AD  - CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic 
      Disorders, Carlos III Health Institute, Monforte de Lemos 3-5, 28029 Madrid, 
      Spain. noelia.ramirez@urv.cat.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20181129
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (Biomarkers)
RN  - 0 (Tobacco Smoke Pollution)
RN  - 6M3C89ZY6R (Nicotine)
RN  - K5161X06LL (Cotinine)
SB  - IM
MH  - Air Pollution, Indoor/*analysis
MH  - Biomarkers/*analysis/metabolism
MH  - Cotinine/*analysis/urine
MH  - Environmental Monitoring
MH  - Hair/chemistry
MH  - Humans
MH  - Nicotine/*adverse effects/analysis
MH  - Saliva/chemistry
MH  - Nicotiana/*chemistry/metabolism
MH  - Tobacco Smoke Pollution/*analysis
PMC - PMC6313747
OTO - NOTNLM
OT  - biomonitoring
OT  - environmental tobacco smoke
OT  - secondhand smoke
OT  - thirdhand smoke
OT  - tobacco exposure biomarkers
COIS- The authors declare no conflict of interest.
EDAT- 2018/12/07 06:00
MHDA- 2019/04/19 06:00
PMCR- 2018/12/01
CRDT- 2018/12/02 06:00
PHST- 2018/08/31 00:00 [received]
PHST- 2018/11/19 00:00 [revised]
PHST- 2018/11/22 00:00 [accepted]
PHST- 2018/12/02 06:00 [entrez]
PHST- 2018/12/07 06:00 [pubmed]
PHST- 2019/04/19 06:00 [medline]
PHST- 2018/12/01 00:00 [pmc-release]
AID - ijerph15122693 [pii]
AID - ijerph-15-02693 [pii]
AID - 10.3390/ijerph15122693 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2018 Nov 29;15(12):2693. doi: 
      10.3390/ijerph15122693.