PMID- 30502242
OWN - NLM
STAT- MEDLINE
DCOM- 20191113
LR  - 20191113
IS  - 1095-8673 (Electronic)
IS  - 0022-4804 (Linking)
VI  - 233
DP  - 2019 Jan
TI  - Outcomes of Elderly Patients Undergoing Curative Resection for Retroperitoneal 
      Sarcomas: Analysis From the US Sarcoma Collaborative.
PG  - 154-162
LID - S0022-4804(18)30531-6 [pii]
LID - 10.1016/j.jss.2018.07.050 [doi]
AB  - BACKGROUND: The postoperative outcomes of elderly patients undergoing resection 
      of retroperitoneal sarcomas (RPS) have not been widely studied. METHODS: Patients 
      undergoing surgical resection for primary or recurrent RPS between 2000 and 2015 
      at participating US Sarcoma Collaborative institutions were identified. Patient 
      demographics, perioperative morbidity, mortality, length of stay, discharge to 
      home, disease-specific survival, and disease-free survival were compared between 
      elderly (>/=70 y, n = 171) and nonelderly (<70 y, n = 494) patients. RESULTS: There 
      was no difference in perioperative morbidity (total and major complications 
      elderly versus nonelderly: 39% versus 35%; P = 0.401 and 18% versus 17%; 
      P = 0.646, respectively) or mortality between elderly and nonelderly patients 
      with each group experiencing a 1% 30-d mortality rate. Length of stay and 30-d 
      readmission rates were similar (elderly versus nonelderly; 7 d interquartile 
      range [IQR: 5-9] versus 6 d [IQR: 4-9], P = 0.528 and 11% versus 12%, P = 0.667). 
      Elderly patients were more likely to be discharged to a skilled nursing or 
      rehabilitation facility (elderly versus nonelderly; 19% versus 7%, P < 0.001). 
      There was no difference in 3-y disease-free survival between the elderly and 
      nonelderly patients (41% versus 43%, P = 0.65); however, elderly patients had a 
      lower 3-y disease-specific survival (60% versus 76%, P < 0.001). In elderly 
      patients, the presence of multiple comorbidities and high-grade tumors were most 
      predictive of outcomes. CONCLUSIONS: Advanced age was not associated with an 
      increased risk of perioperative morbidity and mortality following resection of 
      RPS in this multi-institutional review. Although short-term oncologic outcomes 
      were similar in both groups, the risk of death after sarcoma recurrence was 
      higher in elderly patients and may be related to comorbidity burden and tumor 
      histology.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Wilkinson, Katheryn Hope
AU  - Wilkinson KH
AD  - Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
FAU - Ethun, Cecilia G
AU  - Ethun CG
AD  - Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, 
      Georgia.
FAU - Hembrook, Matthew
AU  - Hembrook M
AD  - Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, 
      Wisconsin.
FAU - Bedi, Meena
AU  - Bedi M
AD  - Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, 
      Wisconsin.
FAU - Charlson, John
AU  - Charlson J
AD  - Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, 
      Wisconsin.
FAU - Mogal, Harveshp
AU  - Mogal H
AD  - Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, 
      Wisconsin.
FAU - Tsai, Susan
AU  - Tsai S
AD  - Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, 
      Wisconsin.
FAU - Christians, Kathleen
AU  - Christians K
AD  - Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, 
      Wisconsin.
FAU - Tran, Thuy B
AU  - Tran TB
AD  - Department of Surgery, Stanford University, Palo Alto, California.
FAU - Poultsides, George
AU  - Poultsides G
AD  - Division of Surgical Oncology, Stanford University, Palo Alto, California.
FAU - Grignol, Valerie
AU  - Grignol V
AD  - Division of Surgical Oncology, The Ohio State University, Columbus, Ohio.
FAU - Howard, John Harrison
AU  - Howard JH
AD  - Division of Surgical Oncology, The Ohio State University, Columbus, Ohio.
FAU - Tseng, Jennifer
AU  - Tseng J
AD  - Division of Surgical Oncology, University of Chicago Medicine, Chicago, Illinois.
FAU - Roggin, Kevin K
AU  - Roggin KK
AD  - Division of Surgical Oncology, University of Chicago Medicine, Chicago, Illinois.
FAU - Chouliaras, Konstantinos
AU  - Chouliaras K
AD  - Division of Surgical Oncology, Wake Forest University, Winston-Salem, North 
      Carolina.
FAU - Votanopoulos, Konstantinos
AU  - Votanopoulos K
AD  - Division of Surgical Oncology, Wake Forest University, Winston-Salem, North 
      Carolina.
FAU - Cullinan, Darren
AU  - Cullinan D
AD  - Department of Surgery, Washington University, St. Louis, Missouri.
FAU - Fields, Ryan C
AU  - Fields RC
AD  - Division of Surgical Oncology, Washington University, St. Louis, Missouri.
FAU - Weber, Sharon
AU  - Weber S
AD  - Division of Surgical Oncology, University of Wisconsin, Madison, Wisconsin.
FAU - Gamblin, Thomas Clark
AU  - Gamblin TC
AD  - Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, 
      Wisconsin.
FAU - Cardona, Kenneth
AU  - Cardona K
AD  - Division of Surgical Oncology, Winship Cancer Institute, Emory University, 
      Atlanta, Georgia.
FAU - Clarke, Callisia N
AU  - Clarke CN
AD  - Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin. 
      Electronic address: cnclarke@mcw.edu.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20180822
PL  - United States
TA  - J Surg Res
JT  - The Journal of surgical research
JID - 0376340
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/mortality/pathology/*prevention & control
MH  - Postoperative Complications/*epidemiology
MH  - Prognosis
MH  - Retroperitoneal Neoplasms/mortality/pathology/*surgery
MH  - Retroperitoneal Space/pathology/surgery
MH  - Retrospective Studies
MH  - Sarcoma/mortality/pathology/*surgery
MH  - Survival Rate
MH  - United States/epidemiology
OTO - NOTNLM
OT  - Cancer directed surgery
OT  - Elderly
OT  - Sarcoma
EDAT- 2018/12/07 06:00
MHDA- 2019/11/14 06:00
CRDT- 2018/12/04 06:00
PHST- 2018/03/05 00:00 [received]
PHST- 2018/06/13 00:00 [revised]
PHST- 2018/07/13 00:00 [accepted]
PHST- 2018/12/04 06:00 [entrez]
PHST- 2018/12/07 06:00 [pubmed]
PHST- 2019/11/14 06:00 [medline]
AID - S0022-4804(18)30531-6 [pii]
AID - 10.1016/j.jss.2018.07.050 [doi]
PST - ppublish
SO  - J Surg Res. 2019 Jan;233:154-162. doi: 10.1016/j.jss.2018.07.050. Epub 2018 Aug 
      22.