PMID- 30503697
OWN - NLM
STAT- MEDLINE
DCOM- 20190510
LR  - 20190510
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1591
DP  - 2019 Apr 26
TI  - Graphene oxide-starch-based micro-solid phase extraction of antibiotic residues 
      from milk samples.
PG  - 7-14
LID - S0021-9673(18)31494-8 [pii]
LID - 10.1016/j.chroma.2018.11.069 [doi]
AB  - In this study, a method was described for the extraction of three antibiotic 
      residues from cow milk samples using a graphene oxide-starch-based nanocomposite. 
      The prepared nanocomposites were employed as an extractive phase for micro-solid 
      phase extraction of antibiotics from cow milk samples. The extracted antibiotics, 
      i.e. amoxicillin, ampicillin and cloxacillin, were subsequently analyzed by 
      high-performance liquid chromatography-ultraviolet detection (HPLC-UV). Important 
      variables associated with the extraction and desorption efficiency were 
      optimized. High extraction efficiencies for the selected antibiotics were 
      conveniently achieved using the starch-based nanocomposite as the extractive 
      phase. The developed method was validated according to the European Commission 
      Decision 2002/657/EC by spiking the selected antibiotics to the blank milk 
      samples. The limits of quantitation (2.7-5.0 mug kg(-1)) were calculated for the 
      selected penicillin group in milk samples and their quantities are lower than the 
      maximum residue limits (MRLs). The obtained results indicate the remarkable 
      efficiency of the graphene oxide-starch-based nanocomposite performance toward 
      the selected antibiotics. The relative standard deviations of intra and inter-day 
      analysis are less than 3.3 and 6.1%, respectively. Moreover, trueness of method 
      was successfully accomplished via the recovery assays (88-102%) in the fortified 
      blank milk samples with three different concentration levels (MRL, 1.5 MRL and 3 
      MRL mug kg(-1)). In overall, the proposed method was a promising alternative for 
      analysis of selected three antibiotics in variety milk samples, due to the 
      effective and easy-to-perform method and acceptable relative recovery in the 
      range 83-105%.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Golzari Aqda, Tahereh
AU  - Golzari Aqda T
AD  - Environmental and Bio-Analytical Laboratories, Department of Chemistry Sharif 
      University of Technology, P.O. Box 11365-9516, Tehran, Iran.
FAU - Behkami, Shima
AU  - Behkami S
AD  - Environmental and Bio-Analytical Laboratories, Department of Chemistry Sharif 
      University of Technology, P.O. Box 11365-9516, Tehran, Iran.
FAU - Raoofi, Mehrnoosh
AU  - Raoofi M
AD  - Environmental and Bio-Analytical Laboratories, Department of Chemistry Sharif 
      University of Technology, P.O. Box 11365-9516, Tehran, Iran.
FAU - Bagheri, Habib
AU  - Bagheri H
AD  - Environmental and Bio-Analytical Laboratories, Department of Chemistry Sharif 
      University of Technology, P.O. Box 11365-9516, Tehran, Iran. Electronic address: 
      bagheri@sharif.edu.
LA  - eng
PT  - Journal Article
DEP - 20181126
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (graphene oxide)
RN  - 7782-42-5 (Graphite)
RN  - 9005-25-8 (Starch)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/analysis/*isolation & purification
MH  - Cattle
MH  - Female
MH  - Graphite/*chemistry
MH  - Milk/*chemistry
MH  - Reproducibility of Results
MH  - Solid Phase Microextraction/*methods
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Starch/*chemistry
OTO - NOTNLM
OT  - Antibiotics
OT  - Graphene oxide-starch-based nanocomposite
OT  - HPLC-UV
OT  - Micro-solid phase extraction
OT  - Milk analysis
EDAT- 2018/12/07 06:00
MHDA- 2019/05/11 06:00
CRDT- 2018/12/04 06:00
PHST- 2018/10/06 00:00 [received]
PHST- 2018/11/21 00:00 [revised]
PHST- 2018/11/24 00:00 [accepted]
PHST- 2018/12/07 06:00 [pubmed]
PHST- 2019/05/11 06:00 [medline]
PHST- 2018/12/04 06:00 [entrez]
AID - S0021-9673(18)31494-8 [pii]
AID - 10.1016/j.chroma.2018.11.069 [doi]
PST - ppublish
SO  - J Chromatogr A. 2019 Apr 26;1591:7-14. doi: 10.1016/j.chroma.2018.11.069. Epub 
      2018 Nov 26.