PMID- 30506419
OWN - NLM
STAT- MEDLINE
DCOM- 20191017
LR  - 20200225
IS  - 1435-165X (Electronic)
IS  - 1018-8827 (Linking)
VI  - 28
IP  - 7
DP  - 2019 Jul
TI  - Clinical high risk for psychosis in childhood and adolescence: findings from the 
      2-year follow-up of the ReARMS project.
PG  - 957-971
LID - 10.1007/s00787-018-1262-5 [doi]
AB  - The clinical significance and the prognostic value of clinical high risk (CHR) 
      for psychosis, while substantially corroborated in adults, remains less firmly 
      established in children and early adolescents. This follow-up study, developed 
      within the Reggio Emilia At Risk Mental States project, is meant to contribute to 
      the reduction of such lacuna, and has two main aims: (1) to characterize the 
      clinical profile of help seekers [stratified in non-CHR, CHR and first episode 
      psychosis (FEP)] referred to child-adolescent mental health services; and (2) to 
      monitor the cumulative transition rate from CHR to FEP in adolescents at the 
      follow-up of 12 and 24 months. 112 adolescents (aged 13-18 years) were assessed 
      with the Comprehensive Assessment of At-Risk Mental States and the Schizophrenia 
      Proneness Instrument, Child and Youth version. 51 subjects met CHR criteria 
      (45.5% of the sample) and 33 subjects met FEP criteria (29.5%) at baseline. The 
      criterial transition rate from CHR to FEP was 7% over 12 months and 13% over 
      24 months; higher rates of cumulative transition were detected when also 
      functional transition (indexed by the consensual introduction of antipsychotic 
      medication by the treating clinical staff) was considered. The identification of 
      CHR for psychosis in help-seeking adolescents is feasible and clinically 
      relevant. Studies conducted in real world, publicly funded components of the 
      national health system, should take into consideration not only criterial, 
      psychometric transition, but also functional equivalents of transition.
FAU - Poletti, Michele
AU  - Poletti M
AD  - Department of Mental Health and Pathological Addiction, AUSL-IRCSS di Reggio 
      Emilia, Via Amendola n.2, 42100, Reggio Emilia (RE), Italy.
FAU - Pelizza, Lorenzo
AU  - Pelizza L
AUID- ORCID: 0000-0003-4746-2061
AD  - Department of Mental Health and Pathological Addiction, AUSL-IRCSS di Reggio 
      Emilia, Via Amendola n.2, 42100, Reggio Emilia (RE), Italy. 
      lorenzo.pelizza@ausl.re.it.
FAU - Azzali, Silvia
AU  - Azzali S
AD  - Department of Mental Health and Pathological Addiction, AUSL-IRCSS di Reggio 
      Emilia, Via Amendola n.2, 42100, Reggio Emilia (RE), Italy.
FAU - Paterlini, Federica
AU  - Paterlini F
AD  - Department of Mental Health and Pathological Addiction, AUSL-IRCSS di Reggio 
      Emilia, Via Amendola n.2, 42100, Reggio Emilia (RE), Italy.
FAU - Garlassi, Sara
AU  - Garlassi S
AD  - Department of Mental Health and Pathological Addiction, AUSL-IRCSS di Reggio 
      Emilia, Via Amendola n.2, 42100, Reggio Emilia (RE), Italy.
FAU - Scazza, Ilaria
AU  - Scazza I
AD  - Department of Mental Health and Pathological Addiction, AUSL-IRCSS di Reggio 
      Emilia, Via Amendola n.2, 42100, Reggio Emilia (RE), Italy.
FAU - Chiri, Luigi Rocco
AU  - Chiri LR
AD  - Department of Mental Health and Pathological Addiction, AUSL di Bologna, Bologna, 
      Italy.
FAU - Gebhardt, Eva
AU  - Gebhardt E
AD  - Cmed Polyspecialistic Diagnostic and Therapeutic Centre, Rome, Italy.
FAU - Pupo, Simona
AU  - Pupo S
AD  - Intensive Care Unit, Anesthesia and Resuscitation Service, Guastalla Civil 
      Hospital, AUSL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
FAU - Andrea, Raballo
AU  - Andrea R
AD  - Department of Psychology, Childhood and Development Research Group, Norwegian 
      University of Science and Technology (NTNU), Trondheim, Norway.
LA  - eng
PT  - Journal Article
DEP - 20181201
PL  - Germany
TA  - Eur Child Adolesc Psychiatry
JT  - European child & adolescent psychiatry
JID - 9212296
SB  - IM
MH  - Adolescent
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Psychotic Disorders/*psychology
OTO - NOTNLM
OT  - Attenuated psychosis syndrome
OT  - Basic symptoms
OT  - Clinical high risk
OT  - Criterial transition
OT  - Functional transition
OT  - Ultrahigh risk
EDAT- 2018/12/07 06:00
MHDA- 2019/10/18 06:00
CRDT- 2018/12/04 06:00
PHST- 2017/11/25 00:00 [received]
PHST- 2018/11/29 00:00 [accepted]
PHST- 2018/12/07 06:00 [pubmed]
PHST- 2019/10/18 06:00 [medline]
PHST- 2018/12/04 06:00 [entrez]
AID - 10.1007/s00787-018-1262-5 [pii]
AID - 10.1007/s00787-018-1262-5 [doi]
PST - ppublish
SO  - Eur Child Adolesc Psychiatry. 2019 Jul;28(7):957-971. doi: 
      10.1007/s00787-018-1262-5. Epub 2018 Dec 1.