PMID- 30508134 OWN - NLM STAT- MEDLINE DCOM- 20200916 LR - 20201024 IS - 1745-1701 (Electronic) IS - 0586-7614 (Print) IS - 0586-7614 (Linking) VI - 45 IP - 6 DP - 2019 Oct 24 TI - A Dissociation in Effects of Risperidone Monotherapy on Functional and Anatomical Connectivity Within the Default Mode Network. PG - 1309-1318 LID - 10.1093/schbul/sby175 [doi] AB - Respective changes in functional and anatomical connectivities of default mode network (DMN) after antipsychotic treatment have been reported. However, alterations in structure-function coupling after treatment remain unknown. We performed diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging in 42 drug-naive first-episode schizophrenia patients (FESP) both at baseline and after 8-weeks risperidone monotherapy, and in 38 healthy volunteers. Independent component analysis was used to assess voxel-wise DMN synchrony. A 3-step procedure was used to trace fiber paths between DMN components. Structure-function couplings were assessed by Pearson's correlations between mean fractional anisotropy and temporal correlation coefficients in major tracts of DMN. Pretreatment, FESP showed impaired functional connectivity in posterior cingulate cortex/precuneus (PCC/PCUN) and medial prefrontal cortex (mPFC), but no abnormalities in fibers connecting DMN components. After treatment, there were significant increases in functional connectivities of PCC/PCUN. Increases in functional connectivity between PCC/PCUN and mPFC correlated with improvement in positive symptoms. The structure-function coupling in tracts connecting PCC/PCUN and bilateral medial temporal lobes decreased after treatment. No alterations in DMN fiber integrity were detected. This combination of functional and anatomical findings in FESP contributes novel evidence related to neurobehavioral treatment effects. Increased functional connectivities between PCC/PCUN and mPFC may be treatment response biomarkers for positive symptoms. Increases in functional connectivities, no alterations in fiber integrity, combined with decreases in structural-functional coupling, suggest that DMN connectivities may be dissociated by modality after 8-week treatment. Major limitations of this study, however, include lack of repeat scans in healthy volunteers and control group of patients taking placebo or comparator antipsychotics. CI - (c) The Author(s) 2018. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com. FAU - Zong, Xiaofen AU - Zong X AD - Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. AD - Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China. AD - Division of Molecular Imaging and Neuropathology, Columbia University and New York State Psychiatric Institute, New York, NY. FAU - Hu, Maolin AU - Hu M AD - Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. AD - Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China. AD - Division of Molecular Imaging and Neuropathology, Columbia University and New York State Psychiatric Institute, New York, NY. FAU - Pantazatos, Spiro P AU - Pantazatos SP AD - Division of Molecular Imaging and Neuropathology, Columbia University and New York State Psychiatric Institute, New York, NY. AD - Department of Psychiatry, Columbia University, New York, NY. FAU - Mann, J John AU - Mann JJ AD - Division of Molecular Imaging and Neuropathology, Columbia University and New York State Psychiatric Institute, New York, NY. AD - Department of Psychiatry, Columbia University, New York, NY. FAU - Wang, Gaohua AU - Wang G AD - Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China. FAU - Liao, Yanhui AU - Liao Y AD - Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. FAU - Liu, Zhong-Chun AU - Liu ZC AD - Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China. FAU - Liao, Wei AU - Liao W AD - Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, China. FAU - Yao, Tao AU - Yao T AD - Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China. FAU - Li, Zongchang AU - Li Z AD - Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. FAU - He, Ying AU - He Y AD - Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. FAU - Lv, Luxian AU - Lv L AD - Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China. FAU - Sang, Deen AU - Sang D AD - Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China. FAU - Tang, Jinsong AU - Tang J AD - Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. AD - Mental Health Institute of Central South University, Changsha, Hunan, China. AD - National Clinical Research Center on Mental Disorders (Xiangya), National Technology Institute on Mental Disorders, Changsha, Hunan, China. AD - Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, Hunan, China. FAU - Chen, Huafu AU - Chen H AD - Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, China. FAU - Zheng, Junjie AU - Zheng J AD - Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, China. FAU - Chen, Xiaogang AU - Chen X AD - Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. AD - Mental Health Institute of Central South University, Changsha, Hunan, China. AD - National Clinical Research Center on Mental Disorders (Xiangya), National Technology Institute on Mental Disorders, Changsha, Hunan, China. AD - Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, Hunan, China. LA - eng GR - K01 MH108721/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PL - United States TA - Schizophr Bull JT - Schizophrenia bulletin JID - 0236760 RN - 0 (Antipsychotic Agents) RN - L6UH7ZF8HC (Risperidone) SB - IM MH - Adult MH - Antipsychotic Agents/*therapeutic use MH - Brain/diagnostic imaging/physiopathology MH - Case-Control Studies MH - Diffusion Tensor Imaging MH - Female MH - Functional Neuroimaging MH - Gyrus Cinguli/*diagnostic imaging/physiopathology MH - Humans MH - Male MH - Neural Pathways/diagnostic imaging/physiopathology MH - Parietal Lobe/*diagnostic imaging/physiopathology MH - Prefrontal Cortex/*diagnostic imaging/physiopathology MH - Risperidone/*therapeutic use MH - Schizophrenia/diagnostic imaging/*drug therapy/physiopathology MH - Young Adult PMC - PMC6811838 OTO - NOTNLM OT - default mode network OT - diffusion tensor imaging/risperidone OT - functional magnetic resonance imaging OT - schizophrenia EDAT- 2018/12/07 06:00 MHDA- 2020/09/17 06:00 PMCR- 2020/10/24 CRDT- 2018/12/04 06:00 PHST- 2018/12/07 06:00 [pubmed] PHST- 2020/09/17 06:00 [medline] PHST- 2018/12/04 06:00 [entrez] PHST- 2020/10/24 00:00 [pmc-release] AID - 5227405 [pii] AID - sby175 [pii] AID - 10.1093/schbul/sby175 [doi] PST - ppublish SO - Schizophr Bull. 2019 Oct 24;45(6):1309-1318. doi: 10.1093/schbul/sby175.