PMID- 30508356
OWN - NLM
STAT- MEDLINE
DCOM- 20190611
LR  - 20190613
IS  - 1934-578X (Print)
IS  - 1555-9475 (Linking)
VI  - 11
IP  - 12
DP  - 2016 Dec
TI  - Inhibition of the MAPK Signaling Pathway by Red Rice Extract in UVB-irradiated 
      Human Skin Fibroblasts.
PG  - 1877-1882
AB  - Red rice has demonstrated several biological properties including anti-oxidant 
      and anti-inflammation properties. However, the anti-photoaging activity has not 
      yet been investigated; The aim of this study relates to the photo-protective 
      effects of red rice extract (RRE) on UVB-induced skin aging. RRE was prepared and 
      the active compounds and anti-oxidant activity were determined. The cytotoxicity 
      of fibroblasts and secretions of IL-6 and IL-8 were evaluated. The effects of RRE 
      on collagen and hyaluronic acid (HA) synthesis from fibroblasts were evaluated. 
      Then, the collagenase and MMP-2 activity was determined. The effect of RRE on 
      UV-induced MMP-1, nuclear factor kappa B (NF-kappaB), activator protein-I (AP-1) and 
      phosphorylation of MAPK protein expression was determined by western blot 
      analysis. The RRE exerted a free radical scavenging property. RRE significantly 
      increased collagen and HA synthesis in UVB-irradiated human fibroblasts. 
      Moreover, RRE significantly inhibited UVB induced MMP- 1 expression, MMP-2 and 
      collagenase activity. Upon UVB irradiation, mitogen activated protein kinases 
      (MAPKs) is activated and this pathway stimulates the expression of interleukin-6 
      and-8 (IL-6 and-8). Our results show that RRE decreases UVB-induced IL-6 and -8 
      production and the phosphorylation of c-Jun NH2- terminal kinase (JNK) and the 
      p38 MAPK signaling process. In addition, RRE reduced UVB-induced activation of 
      NF-icB and AP-I. RRE could suppress UV-induced inflammation and skin aging via 
      the inhibition of the MAPK signaling pathway leading to the decrease of NF-cB and 
      AP- 1 activation resulting in a decrease in ECM degradation and an increase in 
      ECM synthesis.
FAU - Limtrakul, Pornngarm
AU  - Limtrakul P
FAU - Yodkeeree, Supachai
AU  - Yodkeeree S
FAU - Punfa, Wanisa
AU  - Punfa W
FAU - Srisomboon, Jatupol
AU  - Srisomboon J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nat Prod Commun
JT  - Natural product communications
JID - 101477873
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (NF-kappa B)
RN  - 0 (Plant Extracts)
RN  - 9004-61-9 (Hyaluronic Acid)
RN  - 9007-34-5 (Collagen)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 3.4.24.24 (MMP2 protein, human)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
SB  - IM
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Cells, Cultured
MH  - Collagen/metabolism
MH  - Fibroblasts/*drug effects/metabolism/*radiation effects
MH  - Humans
MH  - Hyaluronic Acid/metabolism
MH  - Matrix Metalloproteinase 2/metabolism
MH  - Mitogen-Activated Protein Kinases/*antagonists & inhibitors
MH  - NF-kappa B/metabolism
MH  - *Oryza
MH  - Phytotherapy
MH  - Plant Extracts/*pharmacology
MH  - Signal Transduction
MH  - Skin/cytology
MH  - Skin Aging/drug effects
MH  - *Ultraviolet Rays
EDAT- 2016/12/01 00:00
MHDA- 2019/06/14 06:00
CRDT- 2018/12/04 06:00
PHST- 2018/12/04 06:00 [entrez]
PHST- 2016/12/01 00:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PST - ppublish
SO  - Nat Prod Commun. 2016 Dec;11(12):1877-1882.