PMID- 30509033
OWN - NLM
STAT- MEDLINE
DCOM- 20190328
LR  - 20190328
IS  - 1509-572X (Electronic)
IS  - 1509-572X (Linking)
VI  - 56
IP  - 2
DP  - 2018
TI  - Hydroxysafflor yellow A promotes alpha-synuclein clearance via regulating autophagy 
      in rotenone-induced Parkinson's disease mice.
PG  - 133-140
LID - 33126 [pii]
LID - 10.5114/fn.2018.76618 [doi]
AB  - Autophagy is an intracellular degradation process that is involved in alpha-synuclein 
      (alpha-syn) homeostasis and Parkinson's disease (PD). The purpose of this study was 
      to investigate whether hydroxysafflor yellow A (HSYA) could promote alpha-syn 
      clearance via regulating autophagy in PD mice. Male C57BL/6 mice were 
      intraperitoneally treated with HSYA. Thirty minutes later, they were 
      intragastrically administered with rotenone at a dose of 30 mg/kg. The hanging 
      wire test was performed at 14 and 28 days. Then, autophagosomes and 
      ultrastructural changes were examined by transmission electron microscopy. The 
      expression of tyrosine hydroxylase (TH), alpha-syn, JNK1, p-JNK1, Bcl-2, p-Bcl-2, 
      Beclin1, autophagy-related proteins (Atg) 7 and 12-5, and the LC3-II/LC3-I ratio 
      were investigated by western blot. The hanging time of HSYA-treated PD mice was 
      significantly increased compared with that of rotenone-induced PD mice (p < 0.05 
      or p < 0.01). Compared with rotenone-induced PD mice, treatment with HSYA 
      augmented the formation of autophagosomes. The expression of TH, p-JNK1/JNK1, 
      Beclin1, Atg7, Atg12-5, p-Bcl-2/Bcl-2, and the LC3-II/LC3-I ratio were 
      significantly increased, whereas the expression of alpha-syn was reduced in the 
      rotenone plus HSYA group. These results indicate that HSYA promoted alpha-syn 
      clearance via regulating autophagy in rotenone-induced PD mice.
FAU - Han, Bing
AU  - Han B
FAU - Wang, Lijie
AU  - Wang L
FAU - Fu, Fenghua
AU  - Fu F
FAU - Wang, Zhenhua
AU  - Wang Z
FAU - Zhang, Leiming
AU  - Zhang L
FAU - Qi, Grace Jia
AU  - Qi GJ
FAU - Wang, Tian
AU  - Wang T
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Folia Neuropathol
JT  - Folia neuropathologica
JID - 9437431
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Quinones)
RN  - 0 (Uncoupling Agents)
RN  - 0 (alpha-Synuclein)
RN  - 03L9OT429T (Rotenone)
RN  - 146087-19-6 (hydroxysafflor yellow A)
RN  - 5S5A2Q39HX (Chalcone)
SB  - IM
MH  - Animals
MH  - Autophagy/*drug effects
MH  - Brain/*drug effects/pathology
MH  - Chalcone/*analogs & derivatives/pharmacology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neuroprotective Agents/pharmacology
MH  - Parkinsonian Disorders/*pathology
MH  - Quinones/*pharmacology
MH  - Rotenone/toxicity
MH  - Uncoupling Agents/toxicity
MH  - alpha-Synuclein/*drug effects
OTO - NOTNLM
OT  - autophagy
OT  - neurotoxicity
OT  - rotenone
OT  - alpha-synuclein
OT  - hydroxysafflor yellow A
EDAT- 2018/12/05 06:00
MHDA- 2019/03/29 06:00
CRDT- 2018/12/05 06:00
PHST- 2018/12/05 06:00 [entrez]
PHST- 2018/12/05 06:00 [pubmed]
PHST- 2019/03/29 06:00 [medline]
AID - 33126 [pii]
AID - 10.5114/fn.2018.76618 [doi]
PST - ppublish
SO  - Folia Neuropathol. 2018;56(2):133-140. doi: 10.5114/fn.2018.76618.