PMID- 30509037
OWN - NLM
STAT- MEDLINE
DCOM- 20190328
LR  - 20221222
IS  - 1509-572X (Electronic)
IS  - 1509-572X (Linking)
VI  - 56
IP  - 3
DP  - 2018
TI  - The level of microRNA 21 is upregulated by rapamycin in serum of tuberous 
      sclerosis complex patients and subependymal giant cell astrocytoma (SEGA)-derived 
      cell cultures.
PG  - 167-174
LID - 33880 [pii]
LID - 10.5114/fn.2018.78695 [doi]
AB  - Tuberous sclerosis complex (TSC) represents a genetic condition, in which the 
      clinical manifestations are caused by the disinhibition of the mammalian target 
      of rapamycin (mTOR) pathway due to mutations in the TSC1 (hamartin) or TSC2 
      (tuberin) genes. The deregulated mTOR activity leads to multi-site tumors, 
      including subependymal giant cell astrocytoma (SEGA). SEGA is a brain tumor that 
      affects around 15% of TSC patients. The aim of the study was to evaluate miR-21 
      expression in the serum of two groups of TSC patients: with or without SEGA 
      tumors. We found no differences in the level of miR-21 depending on the presence 
      of SEGA. Next, we studied the influence of prolonged rapamycin administration on 
      miR-21 level in the blood serum of TSC patients (6-12 months of rapamycin) and in 
      primary cultures of SEGA-derived cells treated with rapamycin in vitro. Here we 
      show that rapamycin treatment leads to the upregulation of miR-21 in both 
      patients' serum and in primary SEGA tumor cells in the culture indicating the 
      regulatory relationship between rapamycin treatment and miR-21 expression.
FAU - Kuzniewska, Bozena
AU  - Kuzniewska B
FAU - Sadowski, Krzysztof
AU  - Sadowski K
FAU - Urbanska, Katarzyna
AU  - Urbanska K
FAU - Urbanska, Malgorzata
AU  - Urbanska M
FAU - Kotulska, Katarzyna
AU  - Kotulska K
FAU - Liszewska, Ewa
AU  - Liszewska E
FAU - Grajkowska, Wieslawa
AU  - Grajkowska W
FAU - Jozwiak, Sergiusz
AU  - Jozwiak S
FAU - Dziembowska, Magdalena
AU  - Dziembowska M
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Folia Neuropathol
JT  - Folia neuropathologica
JID - 9437431
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (MIRN21 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Adolescent
MH  - Antibiotics, Antineoplastic/*therapeutic use
MH  - Astrocytoma/etiology
MH  - Child
MH  - Female
MH  - Humans
MH  - Male
MH  - MicroRNAs/*biosynthesis/*drug effects
MH  - Sirolimus/*therapeutic use
MH  - Tuberous Sclerosis/complications/*drug therapy/metabolism
MH  - Tumor Cells, Cultured
MH  - Up-Regulation
MH  - Young Adult
OTO - NOTNLM
OT  - SEGA
OT  - miR-21
OT  - rapamycin
OT  - tuberous sclerosis
EDAT- 2018/12/05 06:00
MHDA- 2019/03/29 06:00
CRDT- 2018/12/05 06:00
PHST- 2018/12/05 06:00 [entrez]
PHST- 2018/12/05 06:00 [pubmed]
PHST- 2019/03/29 06:00 [medline]
AID - 33880 [pii]
AID - 10.5114/fn.2018.78695 [doi]
PST - ppublish
SO  - Folia Neuropathol. 2018;56(3):167-174. doi: 10.5114/fn.2018.78695.