PMID- 30509803 OWN - NLM STAT- MEDLINE DCOM- 20190215 LR - 20190215 IS - 1879-3363 (Electronic) IS - 0025-326X (Linking) VI - 136 DP - 2018 Nov TI - Different profiles of naturally produced and anthropogenic organohalogens in the livers of cetaceans from the Sea of Japan and the North Pacific Ocean. PG - 230-242 LID - S0025-326X(18)30621-0 [pii] LID - 10.1016/j.marpolbul.2018.08.051 [doi] AB - Levels and profiles of naturally produced halogenated bipyrroles (Br(4)Cl(2)-DBP and Cl(7)-MBP), methoxylated tetrabromodiphenyl ethers (6-MeO-BDE47), anthropogenic perfluoroalkyl substances (PFASs) and legacy persistent organic pollutants (POPs) were investigated in the livers of 14 cetaceans from the Sea of Japan and the North Pacific Ocean. The concentrations of Br(4)Cl(2)-DBP (4 to 4900 ng/g-wet), Cl(7)-MBP (16 to 3960 ng/g-wet) and 6-MeO-BDE47 (7 to 190 ng/g-wet) were higher in the order of killer whales > toothed whales > baleen whales. Profiles of PFASs were dominated by perfluoroundecanoic and perfluorotridecanoic acids (10 to 540 ng/g-wet), sum of which accounted for 70% of total measured PFASs. Regional difference was observed for Cl(7)-MBP and PFASs, which were higher in the Sea of Japan, whereas Br(4)Cl(2)-DBP was in the North Pacific Ocean. Specific accumulation pattern of these natural contaminants in cetaceans around northern Japan could help compare the exposure profile of PFASs and POPs among other geographic regions. CI - Copyright (c) 2018 Elsevier Ltd. All rights reserved. FAU - Fujii, Yukiko AU - Fujii Y AD - Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan. FAU - Kato, Yoshihisa AU - Kato Y AD - Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314-1, Sanuki, Kagawa 769-2193, Japan. FAU - Kozai, Mai AU - Kozai M AD - Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314-1, Sanuki, Kagawa 769-2193, Japan. FAU - Matsuishi, Takashi AU - Matsuishi T AD - Faculty of Fisheries Sciences, Hokkaido University, 3-1-1, Minato-cho, Hakodate, Hokkaido 041-8611, Japan. FAU - Harada, Kouji H AU - Harada KH AD - Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida Konoe, Sakyo, Kyoto 606-8501, Japan. FAU - Koizumi, Akio AU - Koizumi A AD - Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida Konoe, Sakyo, Kyoto 606-8501, Japan. FAU - Kimura, Osamu AU - Kimura O AD - School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Kanazawa, Ishikari-Tobetsu, Hokkaido 061-0293, Japan. FAU - Endo, Tetsuya AU - Endo T AD - School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Kanazawa, Ishikari-Tobetsu, Hokkaido 061-0293, Japan. FAU - Haraguchi, Koichi AU - Haraguchi K AD - Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan. Electronic address: k-haraguti@daiichi-cps.ac.jp. LA - eng PT - Journal Article DEP - 20180915 PL - England TA - Mar Pollut Bull JT - Marine pollution bulletin JID - 0260231 RN - 0 (Hydrocarbons, Halogenated) RN - 0 (Pyrroles) RN - 0 (Water Pollutants, Chemical) SB - IM MH - Animals MH - *Cetacea MH - Environmental Monitoring MH - Female MH - Hydrocarbons, Halogenated/*analysis/chemistry MH - Japan MH - Liver/*chemistry MH - Male MH - Pacific Ocean MH - Pyrroles/analysis/chemistry MH - Water Pollutants, Chemical/*analysis MH - Whale, Killer OTO - NOTNLM OT - Cetacean OT - Japan OT - Natural halogenated bipyrrole OT - Perfluoroalkyl substance EDAT- 2018/12/05 06:00 MHDA- 2019/02/16 06:00 CRDT- 2018/12/05 06:00 PHST- 2017/10/26 00:00 [received] PHST- 2018/06/25 00:00 [revised] PHST- 2018/08/23 00:00 [accepted] PHST- 2018/12/05 06:00 [entrez] PHST- 2018/12/05 06:00 [pubmed] PHST- 2019/02/16 06:00 [medline] AID - S0025-326X(18)30621-0 [pii] AID - 10.1016/j.marpolbul.2018.08.051 [doi] PST - ppublish SO - Mar Pollut Bull. 2018 Nov;136:230-242. doi: 10.1016/j.marpolbul.2018.08.051. Epub 2018 Sep 15.