PMID- 30509964
OWN - NLM
STAT- MEDLINE
DCOM- 20190729
LR  - 20221207
IS  - 1573-4935 (Electronic)
IS  - 0144-8463 (Print)
IS  - 0144-8463 (Linking)
VI  - 39
IP  - 1
DP  - 2019 Jan 31
TI  - A trial sequential meta-analysis of TNF-alpha -308G>A (rs800629) gene polymorphism 
      and susceptibility to colorectal cancer.
LID - BSR20181052 [pii]
LID - 10.1042/BSR20181052 [doi]
AB  - PURPOSE: Tumor necrosis factor-alpha (TNF-alpha), secreted by the activated macrophages, 
      may participate in the onset and progression of colorectal cancer (CRC). The 
      association of TNF-alpha -308 G>A (rs1800629) single-nucleotide polymorphism (SNP) 
      with CRC risk has been investigated by many studies but the results are 
      inconclusive. A trial sequential meta-analysis was performed for precise 
      estimation of the relationship between TNF-alpha -308 G>A gene polymorphism with CRC 
      risk. METHODS: Medline (PubMed), EMBASE (Excerpta-Medica) and Google Scholar were 
      mined for relevant articles. Odds ratios (ORs) and 95% confidence intervals (CIs) 
      were calculated to estimate the significance of association. RESULTS: The pooled 
      analysis indicated no risk associated with TNF-alpha -308 G>A SNP and overall CRC 
      risk in five genetic comparison models, i.e. allelic (A vs. G: P = 0.524; OR = 
      1.074, 95% CI = 0.863-1.335), homozygous (AA vs. GG: P = 0.489; OR = 1.227, 95% 
      CI = 0.688-2.188), heterozygous (AG vs. GG: P = 0.811; OR = 1.024, 95% CI = 
      0.843-1.244), dominant (AA+AG vs. GG: P = 0.630; OR = 1.055, 95% CI = 
      0.849-1.311) and recessive (AA vs. AG+GG: P = 0.549; OR = 1.181, 95% CI = 
      0.686-2.033). Subgroup analysis revealed that TNF-alpha -308 G>A SNP is associated 
      with reduced risk of CRC in Asian ethnicity. The study showed no publication 
      bias. CONCLUSIONS: No association of TNF-alpha -308 G>A SNP with overall CRC risk was 
      found. This SNP is likely to be protective against CRC in Asian population when 
      compared with Caucasian population. Larger prospective-epidemiological studies 
      are warranted to elucidate the roles of TNF-alpha -308 G>A SNP in the etiology of CRC 
      and to endorse the present findings.
CI  - (c) 2019 The Author(s).
FAU - Mandal, Raju K
AU  - Mandal RK
AD  - Research and Scientific Studies Unit, College of Nursing and Allied Health 
      Sciences, Jazan University, Jazan-45142, Saudi Arabia.
FAU - Khan, Munawwar Ali
AU  - Khan MA
AD  - Department of Life and Environmental Sciences, College of Natural and Health 
      Sciences, Zayed University, P.O. Box 19282, Dubai, United Arab Emirates.
FAU - Hussain, Arif
AU  - Hussain A
AD  - School of Life Sciences, Manipal Academy of Higher Education, P.O. Box 345050, 
      Dubai, United Arab Emirates.
FAU - Akhter, Naseem
AU  - Akhter N
AD  - Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Albaha 
      University, Albaha 65431, Saudi Arabia.
FAU - Jawed, Arshad
AU  - Jawed A
AD  - Research and Scientific Studies Unit, College of Nursing and Allied Health 
      Sciences, Jazan University, Jazan-45142, Saudi Arabia.
FAU - Dar, Sajad A
AU  - Dar SA
AD  - Research and Scientific Studies Unit, College of Nursing and Allied Health 
      Sciences, Jazan University, Jazan-45142, Saudi Arabia.
FAU - Wahid, Mohd
AU  - Wahid M
AD  - Research and Scientific Studies Unit, College of Nursing and Allied Health 
      Sciences, Jazan University, Jazan-45142, Saudi Arabia.
FAU - Panda, Aditya K
AU  - Panda AK
AD  - Centre for Life Sciences, Central University of Jharkhand, Ranchi 835205, 
      Jharkhand, India.
FAU - Lohani, Mohtashim
AU  - Lohani M
AD  - Department of Emergency Medical Services, College of Applied Medical Sciences, 
      Jazan University, Jazan 45142, Saudi Arabia.
FAU - Mishra, Bhartendu N
AU  - Mishra BN
AD  - Department of Biotechnology, Institute of Engineering and Technology, Lucknow 
      226021, Uttar Pradesh, India.
FAU - Haque, Shafiul
AU  - Haque S
AUID- ORCID: 0000-0002-2989-121X
AD  - Research and Scientific Studies Unit, College of Nursing and Allied Health 
      Sciences, Jazan University, Jazan-45142, Saudi Arabia shafiul.haque@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20190115
PL  - England
TA  - Biosci Rep
JT  - Bioscience reports
JID - 8102797
RN  - 0 (Tumor Necrosis Factor-alpha)
MH  - Asian People
MH  - Clinical Trials as Topic
MH  - Colorectal Neoplasms/diagnosis/ethnology/*genetics/pathology
MH  - Gene Expression
MH  - Genotype
MH  - Heterozygote
MH  - Homozygote
MH  - Humans
MH  - Models, Genetic
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
MH  - *Promoter Regions, Genetic
MH  - Tumor Necrosis Factor-alpha/*genetics
MH  - White People
PMC - PMC6331670
OTO - NOTNLM
OT  - Colorectal cancer
OT  - Meta-analysis
OT  - Tumor Necrosis Factor-alpha
OT  - polymorphism
OT  - susceptibility
COIS- The authors declare that there are no competing interests associated with the 
      manuscript.
EDAT- 2018/12/05 06:00
MHDA- 2019/07/30 06:00
PMCR- 2019/01/15
CRDT- 2018/12/05 06:00
PHST- 2018/06/29 00:00 [received]
PHST- 2018/10/29 00:00 [revised]
PHST- 2018/11/29 00:00 [accepted]
PHST- 2018/12/05 06:00 [pubmed]
PHST- 2019/07/30 06:00 [medline]
PHST- 2018/12/05 06:00 [entrez]
PHST- 2019/01/15 00:00 [pmc-release]
AID - BSR20181052 [pii]
AID - 10.1042/BSR20181052 [doi]
PST - epublish
SO  - Biosci Rep. 2019 Jan 15;39(1):BSR20181052. doi: 10.1042/BSR20181052. Print 2019 
      Jan 31.