PMID- 30510823
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220411
IS  - 2090-6625 (Print)
IS  - 2090-6633 (Electronic)
VI  - 2018
DP  - 2018
TI  - Strongyloidosis Hyperinfection Syndrome in an HIV-Infected Patient: A Rare 
      Manifestation of Immune Reconstitution Inflammatory Syndrome.
PG  - 6870768
LID - 10.1155/2018/6870768 [doi]
LID - 6870768
AB  - Parasitic infections such as Strongyloides stercoralis and HIV have been reported 
      to coexist, particularly in resource-limited settings such as India. In an 
      immunocompromised host, S. stercoralis can progress to strongyloidiasis 
      hyperinfection syndrome (SHS). However, SHS is not common in patients with 
      advanced HIV disease. Immune reconstitution inflammatory syndrome (IRIS) 
      developing after initiation of antiretroviral therapy (ART) can target multiple 
      pathogens including S. stercoralis. The authors present here a 46-year-old 
      HIV-infected female who was recently diagnosed with HIV-1 infection, started ART, 
      and developed SHS. Her upper GI endoscopy revealed severe gastroduodenitis, and 
      X-ray chest showed extensive bilateral pneumonitis. We could identify S. 
      stercoralis in induced sputum and duodenal biopsy. We could also identify gut 
      inflammation to restrict invading parasites. After receiving antihelminthic 
      therapy, she showed improvement, a course of events that fit the diagnosis of 
      unmasking S. stercoralis IRIS.
FAU - Natrajan, Kartik
AU  - Natrajan K
AD  - Department of Medicine, Poona Hospital and Research Center, Pune, Maharashtra, 
      India.
FAU - Medisetty, Mahenderkumar
AU  - Medisetty M
AD  - Department of Medicine, Poona Hospital and Research Center, Pune, Maharashtra, 
      India.
FAU - Gawali, Raviraj
AU  - Gawali R
AD  - Department of Medicine, Poona Hospital and Research Center, Pune, Maharashtra, 
      India.
FAU - Tambolkar, Ajit
AU  - Tambolkar A
AD  - Department of Medicine, Poona Hospital and Research Center, Pune, Maharashtra, 
      India.
FAU - Patel, Divya
AU  - Patel D
AD  - Department of Pathology, Poona Hospital and Research Center, Pune, Maharashtra, 
      India.
FAU - Thorat, Vinay
AU  - Thorat V
AD  - Department of Gastroenterology, Poona Hospital and Research Center, Pune, 
      Maharashtra, India.
FAU - Dubale, Nachiket
AU  - Dubale N
AD  - Department of Gastroenterology, Poona Hospital and Research Center, Pune, 
      Maharashtra, India.
FAU - Khirid, Vrushali
AU  - Khirid V
AD  - Department of Pulmonology, Poona Hospital and Research Center, Pune, Maharashtra, 
      India.
FAU - Saraf, Chinmay
AU  - Saraf C
AD  - Precision Diagnostics and Biosciences, Pune, Maharashtra, India.
FAU - Dravid, Ameet
AU  - Dravid A
AUID- ORCID: 0000-0002-1909-7530
AD  - Department of Medicine, Poona Hospital and Research Center, Pune, Maharashtra, 
      India.
LA  - eng
PT  - Case Reports
DEP - 20181028
PL  - Egypt
TA  - Case Rep Infect Dis
JT  - Case reports in infectious diseases
JID - 101573243
PMC - PMC6230409
EDAT- 2018/12/05 06:00
MHDA- 2018/12/05 06:01
PMCR- 2018/10/28
CRDT- 2018/12/05 06:00
PHST- 2018/08/14 00:00 [received]
PHST- 2018/10/16 00:00 [accepted]
PHST- 2018/12/05 06:00 [entrez]
PHST- 2018/12/05 06:00 [pubmed]
PHST- 2018/12/05 06:01 [medline]
PHST- 2018/10/28 00:00 [pmc-release]
AID - 10.1155/2018/6870768 [doi]
PST - epublish
SO  - Case Rep Infect Dis. 2018 Oct 28;2018:6870768. doi: 10.1155/2018/6870768. 
      eCollection 2018.