PMID- 30512169
OWN - NLM
STAT- MEDLINE
DCOM- 20190701
LR  - 20190701
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 35
IP  - 6
DP  - 2018 Dec 10
TI  - [Clinical and laboratory characteristics of hematopathy with t(5;12)(q33;p13) 
      translocation].
PG  - 879-882
LID - 10.3760/cma.j.issn.1003-9406.2018.06.025 [doi]
AB  - OBJECTIVE: To investigate the clinical and laboratory characteristics of 
      hematopoietic tumor with t(5;12)(q33;p13). To sum up the similarities and 
      differences of these diseases. METHODS: The chromosome samples were prepared by 
      short-term training of bone marrow cells, and the karyotype analysis was carried 
      out by R or G band. Using PDGFRb dual color fracture rearrangement probe and 
      fluorescence in situ hybridization (FISH) technology to detect the rearrangement 
      of the gene, the immune-typing analysis was performed using flow cytometry. For 7 
      cases with t(5;12)(q33;p13) patients with hematopathy were retrospectively 
      analyzed. RESULTS: Seven patients were diagnosed with different diagnoses, mainly 
      male. Nuclear type analysis 5 cases of t(5;12)(q33;p13) was of primary 
      abnormality and 2 cases of secondary abnormality. Five of the seven patients were 
      treated and two untreated. Among the treatment patients, two cases were fatal, 
      two case was lost and one case was treated with combined chemotherapy with 
      dasatinib targeted therapy. The treatment process was successful and is still in 
      hospital. CONCLUSION: With t (5;12) (q33;p13) blood system tumors are rare and 
      have unique clinical and laboratory characteristics. At the same time, the 
      heterogeneity is obvious, the patients with tyrosine kinase inhibitor combined 
      with chemotherapy have good effect and good prognosis, and the prognosis of 
      chemotherapy alone is poor.
FAU - Wang, Siping
AU  - Wang S
AD  - Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, 
      China. wangjx@ihcams.ac.cn.
FAU - Li, Li
AU  - Li L
FAU - Wang, Jianxiang
AU  - Wang J
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
SB  - IM
MH  - Chromosomes, Human, Pair 12/*genetics
MH  - Chromosomes, Human, Pair 5/*genetics
MH  - Hematologic Neoplasms/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Retrospective Studies
MH  - *Translocation, Genetic
EDAT- 2018/12/05 06:00
MHDA- 2019/07/02 06:00
CRDT- 2018/12/05 06:00
PHST- 2018/12/05 06:00 [entrez]
PHST- 2018/12/05 06:00 [pubmed]
PHST- 2019/07/02 06:00 [medline]
AID - 940635184 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2018.06.025 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2018 Dec 10;35(6):879-882. doi: 
      10.3760/cma.j.issn.1003-9406.2018.06.025.