PMID- 30513347
OWN - NLM
STAT- MEDLINE
DCOM- 20200819
LR  - 20200819
IS  - 1528-8447 (Electronic)
IS  - 1526-5900 (Linking)
VI  - 20
IP  - 5
DP  - 2019 May
TI  - Enlarged Areas of Pain and Pressure Hypersensitivityby Spatially Distributed 
      Intramuscular Injections ofLow-Dose Nerve Growth Factor.
PG  - 566-576
LID - S1526-5900(18)30438-3 [pii]
LID - 10.1016/j.jpain.2018.11.005 [doi]
AB  - Intramuscular injection of nerve growth factor (NGF) causes muscle hyperalgesia 
      without immediate pain. This double-blinded, randomized study assessed pain and 
      muscle hypersensitivity after a single-site bolus NGF injection (5 microg) compared 
      with 5 spatially distributed, low-dose NGF injections (1 microg, 4 cm distance) into 
      the tibialis anterior (TA) muscles in 20 healthy subjects. Injection pain was 
      rated on a visual analog scale. Reports of muscle pain with functional tasks 
      (Likert scale score) and the presence of spontaneous pain were collected daily by 
      using a diary. Pressure pain threshold (PPT), overall pain intensity (numerical 
      rating scale), and pain areas following the TA contraction were collected at 
      baseline; 3 hours; and 1, 3, 7, 14, and 21 days postinjection. Low immediate 
      visual analog scale scores were associated with both injection protocols. Likert 
      scale scores showed moderate pain intensities but no spontaneous pain, until day 
      12, for both injection protocols (P < .05). Reduced PPTs at the 5- and 1-microg 
      injection sites were found after 3 hours, lasting until day 7 (P < .05). The 1-microg 
      injection provoked decreased PPTs at day 1 (P = .036) at the proximal injection 
      site and at day 1 (P = .02) and day 3 (P = .01) at the distal injection site. The 
      TA muscle contraction resulted in larger pain areas and higher numerical rating 
      scale scores at day 3 for the distributed injections compared with the 
      single-site injection (P < .001). Perspective: Spatially distributed low-dose NGF 
      injections induced prolonged pain, mechanical muscle hypersensitivity, and 
      enlarged contraction-evoked pain areas. These features mirror some clinical 
      muscle pain conditions in which diffuse pain areas and muscle hypersensitivity 
      are present during the activities of daily living. Low-dose NGF injections may be 
      useful for further studies of prolonged pain conditions.
CI  - Copyright (c) 2018 the American Pain Society. Published by Elsevier Inc. All rights 
      reserved.
FAU - Sorensen, Line B
AU  - Sorensen LB
AD  - Center for Neuroplasticity and Pain (CNAP), SMI.
FAU - Boudreau, Shellie A
AU  - Boudreau SA
AD  - Center for Neuroplasticity and Pain (CNAP), SMI.
FAU - Gazerani, Parisa
AU  - Gazerani P
AD  - Biomedicine, Department of Health Science and Technology, Faculty of Medicine, 
      Aalborg University, Aalborg, Denmark.
FAU - Graven-Nielsen, Thomas
AU  - Graven-Nielsen T
AD  - Center for Neuroplasticity and Pain (CNAP), SMI. Electronic address: 
      tgn@hst.aau.dk.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20181201
PL  - United States
TA  - J Pain
JT  - The journal of pain
JID - 100898657
RN  - 0 (Neuromuscular Agents)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Hyperalgesia/*etiology
MH  - Injections, Intramuscular
MH  - Male
MH  - Muscle Contraction
MH  - Myalgia/*etiology
MH  - Nerve Growth Factor/*administration & dosage
MH  - Neuromuscular Agents/*administration & dosage
MH  - Pain Measurement
MH  - Pressure
MH  - Young Adult
OTO - NOTNLM
OT  - Nerve growth factor
OT  - hyperalgesia
OT  - injection
OT  - muscle contraction
OT  - pain measurements
EDAT- 2018/12/05 06:00
MHDA- 2020/08/20 06:00
CRDT- 2018/12/05 06:00
PHST- 2018/08/13 00:00 [received]
PHST- 2018/10/26 00:00 [revised]
PHST- 2018/11/13 00:00 [accepted]
PHST- 2018/12/05 06:00 [pubmed]
PHST- 2020/08/20 06:00 [medline]
PHST- 2018/12/05 06:00 [entrez]
AID - S1526-5900(18)30438-3 [pii]
AID - 10.1016/j.jpain.2018.11.005 [doi]
PST - ppublish
SO  - J Pain. 2019 May;20(5):566-576. doi: 10.1016/j.jpain.2018.11.005. Epub 2018 Dec 
      1.