PMID- 30515565
OWN - NLM
STAT- MEDLINE
DCOM- 20190219
LR  - 20200225
IS  - 1432-2307 (Electronic)
IS  - 0945-6317 (Linking)
VI  - 474
IP  - 2
DP  - 2019 Feb
TI  - HLA testing in the molecular diagnostic laboratory.
PG  - 139-147
LID - 10.1007/s00428-018-2501-3 [doi]
AB  - The human leukocyte antigen (HLA) system is a highly polymorphic family of genes 
      involved in immunity and responsible for identifying self versus non-self. HLA 
      typing is essential for solid organ and bone marrow transplantation as well as in 
      non-transplant settings such as disease association and pharmacogenomics. Typing 
      of HLA genes differs from most molecular testing as, rather than evaluating 
      differences from an accepted "wild-type" gene, it must distinguish between 
      thousands of similar, but distinct alleles. This article will describe the HLA 
      system and nomenclature. We will then discuss clinical uses of HLA typing 
      including solid organ transplantation, hematopoietic stem cell transplantation, 
      evaluation of platelet refractory patients, disease association, and 
      pharmacogenetics. Finally, we describe common molecular methods of HLA typing.
FAU - Madden, Kathleen
AU  - Madden K
AD  - Department of Pathology, University of New Mexico, MSC08 4640, Reginald Heber 
      Fitz Hall, Room 335, 1 University of New Mexico, 87131, Albuquerque, NM, Mexico.
FAU - Chabot-Richards, Devon
AU  - Chabot-Richards D
AUID- ORCID: 0000-0002-6437-8438
AD  - Department of Pathology, University of New Mexico, MSC08 4640, Reginald Heber 
      Fitz Hall, Room 335, 1 University of New Mexico, 87131, Albuquerque, NM, Mexico. 
      Dchabot-richards@salud.unm.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20181204
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Alleles
MH  - Genotype
MH  - HLA Antigens/*classification/*genetics
MH  - Histocompatibility Antigens Class II/genetics
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Laboratories
MH  - Pathology, Molecular/methods
MH  - Sequence Analysis, DNA/methods
OTO - NOTNLM
OT  - HLA
OT  - Immunogenetics
OT  - Molecular
OT  - SSO
OT  - SSP
OT  - Transplantation
EDAT- 2018/12/06 06:00
MHDA- 2019/03/21 06:00
CRDT- 2018/12/06 06:00
PHST- 2018/07/20 00:00 [received]
PHST- 2018/11/27 00:00 [accepted]
PHST- 2018/12/06 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
PHST- 2018/12/06 06:00 [entrez]
AID - 10.1007/s00428-018-2501-3 [pii]
AID - 10.1007/s00428-018-2501-3 [doi]
PST - ppublish
SO  - Virchows Arch. 2019 Feb;474(2):139-147. doi: 10.1007/s00428-018-2501-3. Epub 2018 
      Dec 4.