PMID- 30515905
OWN - NLM
STAT- MEDLINE
DCOM- 20190725
LR  - 20220408
IS  - 1523-5378 (Electronic)
IS  - 1083-4389 (Linking)
VI  - 24
IP  - 2
DP  - 2019 Apr
TI  - Clinical features of Helicobacter pylori antibody-positive junior high school 
      students in Nagano Prefecture, Japan.
PG  - e12559
LID - 10.1111/hel.12559 [doi]
AB  - BACKGROUND: Previously, we conducted an epidemiological study screening for 
      Helicobacter pylori antibody positivity among Japanese junior high school 
      students. In this study, we updated the epidemiological data and assessed the 
      clinical features of H pylori antibody-positive junior high school students. 
      MATERIALS AND METHODS: We assessed H pylori antibody-positive subjects who were 
      identified between 2012 and 2015 at four junior high schools in Nagano 
      Prefecture, Japan. H pylori infection was confirmed by urea breath test (UBT) or 
      endoscopic examination. Endoscopy was performed after obtaining consent from the 
      subject and their guardians. Eradication therapy consisted of triple therapy with 
      proton pump inhibitor (PPI), amoxicillin (AMPC), and clarithromycin (CAM) or 
      metronidazole (MNZ) for seven days. Eradication of H pylori was confirmed by UBT. 
      We reviewed subjects' characteristics, endoscopic findings, histological 
      findings, eradication regimes, outcomes, and adverse effects. RESULTS: The 
      overall prevalence of H pylori antibody positivity was 3.2% (42/1298). We 
      assessed thirteen H pylori antibody-positive subjects. Eight subjects had a 
      family history of H pylori infection. Six subjects had abdominal pain, and two 
      subjects had iron deficiency anemia (IDA). Twelve subjects underwent endoscopy; 
      one subject had duodenal ulcer, eleven subjects had antral nodular gastritis, and 
      six subjects showed grade 2 closed type atrophic border according to the 
      Kimura-Takemoto classification. All subjects received eradication therapy; CAM 
      was used in five subjects with CAM susceptibility as well as in three subjects 
      with unknown information on CAM susceptibility, and MNZ was used in five subjects 
      with CAM resistance. Eradication was successful in twelve subjects (one 
      unconfirmed). There were three mild adverse effects (abdominal pain or diarrhea). 
      CONCLUSIONS: Helicobacter pylori test for junior high school students represents 
      an opportunity to diagnose the peptic ulcer, iron deficiency anemia, and gastric 
      atrophy.
CI  - (c) 2018 John Wiley & Sons Ltd.
FAU - Honma, Hitoshi
AU  - Honma H
AD  - Department of Pediatrics, Shinshu University School of Medicine, Nagano, Japan.
FAU - Nakayama, Yoshiko
AU  - Nakayama Y
AUID- ORCID: 0000-0003-1992-6834
AD  - Department of Pediatrics, Shinshu University School of Medicine, Nagano, Japan.
FAU - Kato, Sawako
AU  - Kato S
AD  - Department of Pediatrics, Shinshu University School of Medicine, Nagano, Japan.
FAU - Hidaka, Nao
AU  - Hidaka N
AD  - Department of Pediatrics, Shinshu University School of Medicine, Nagano, Japan.
FAU - Kusakari, Mai
AU  - Kusakari M
AD  - Department of Pediatrics, Shinshu University School of Medicine, Nagano, Japan.
FAU - Sado, Tomomitsu
AU  - Sado T
AD  - Department of Pediatrics, Shinshu University School of Medicine, Nagano, Japan.
FAU - Suda, Ayako
AU  - Suda A
AD  - Department of Pediatrics, Shinshu University School of Medicine, Nagano, Japan.
FAU - Lin, Yingsong
AU  - Lin Y
AD  - Department of Public Health, Aichi Medical University School of Medicine, Aichi, 
      Japan.
LA  - eng
GR  - 23590821/Grant-in-Aid for Scientific Research (C), the Ministry of Education, 
      Culture, Sports, Science and Technology/
PT  - Journal Article
DEP - 20181204
PL  - England
TA  - Helicobacter
JT  - Helicobacter
JID - 9605411
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Antibodies, Bacterial)
MH  - Adolescent
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Antibodies, Bacterial/blood/urine
MH  - Breath Tests
MH  - Child
MH  - Endoscopy
MH  - Female
MH  - Helicobacter Infections/diagnosis/drug therapy/epidemiology/*pathology
MH  - *Helicobacter pylori/drug effects/immunology
MH  - Humans
MH  - Japan/epidemiology
MH  - Male
MH  - Prevalence
MH  - Risk
MH  - Schools
MH  - Students
EDAT- 2018/12/06 06:00
MHDA- 2019/07/26 06:00
CRDT- 2018/12/06 06:00
PHST- 2018/09/15 00:00 [received]
PHST- 2018/11/16 00:00 [revised]
PHST- 2018/11/16 00:00 [accepted]
PHST- 2018/12/06 06:00 [pubmed]
PHST- 2019/07/26 06:00 [medline]
PHST- 2018/12/06 06:00 [entrez]
AID - 10.1111/hel.12559 [doi]
PST - ppublish
SO  - Helicobacter. 2019 Apr;24(2):e12559. doi: 10.1111/hel.12559. Epub 2018 Dec 4.