PMID- 30516492
OWN - NLM
STAT- MEDLINE
DCOM- 20190415
LR  - 20221207
IS  - 1512-0112 (Print)
IS  - 1512-0112 (Linking)
IP  - 283
DP  - 2018 Oct
TI  - SERUM VASCULAR ENDOTHELIAL GROWTH FACTOR CONCENTRATION DECREASES IN CORRELATION 
      WITH GLYCATED HEMOGLOBIN LEVELS IN PATIENTS WITH TYPE 2 DIABETES.
PG  - 55-58
AB  - Our aim was to compare serum vascular endothelial growth factor (VEGF) level in 
      type 2 diabetes mellitus (T2DM) patients with comorbid OSA at screening and 6 
      month follow up visits. In the prospective cohort study following data were 
      collected at screening visit: medical anamnesis; demographic and anthropometric 
      data; Epworth sleepiness score data; laboratory (serum VEGF, complete blood 
      count, biochemistry, immunology, complete urine test, including microalbuminuria) 
      and instrumental investigation data (fundoscophy, laboratory polysomnography). At 
      6 months follow up visit we evaluated anthropometric data; Epworth sleepiness 
      score; serum VEGF. Comparing VEGF level at screening and 6 month follow up visits 
      showed significant decrease in VEGF level in both groups (P=0.0281 OSA+ and 
      P=0.0278 OSA-). It was established direct correlation between decreased VEGF 
      level and decreased HbA1c level (P=0.04696) and between decreased VEGF level and 
      Epworth sleepiness score (P=0.0153) at 6 month follow up visit in OSA+ group. Our 
      the study suggests that VEGF level decreases in parallel with diabetes 
      compensation quality. Future researches are necessary to support this research.
FAU - Kakhniashvili, T
AU  - Kakhniashvili T
AD  - Davit Tvildiani Medical University; Diabetes, Endocrine and Cardio-pulmonary 
      Disease Center "Diacor"; P. Sarajishvili Institute of Neurolog, Tbilisi, Georgia.
FAU - Tabagari-Bregvadze, N
AU  - Tabagari-Bregvadze N
AD  - Davit Tvildiani Medical University; Diabetes, Endocrine and Cardio-pulmonary 
      Disease Center "Diacor"; P. Sarajishvili Institute of Neurolog, Tbilisi, Georgia.
FAU - Dzvelaia, Sh
AU  - Dzvelaia S
AD  - Davit Tvildiani Medical University; Diabetes, Endocrine and Cardio-pulmonary 
      Disease Center "Diacor"; P. Sarajishvili Institute of Neurolog, Tbilisi, Georgia.
FAU - Chikadze, A
AU  - Chikadze A
AD  - Davit Tvildiani Medical University; Diabetes, Endocrine and Cardio-pulmonary 
      Disease Center "Diacor"; P. Sarajishvili Institute of Neurolog, Tbilisi, Georgia.
FAU - Kurashvili, R
AU  - Kurashvili R
AD  - Davit Tvildiani Medical University; Diabetes, Endocrine and Cardio-pulmonary 
      Disease Center "Diacor"; P. Sarajishvili Institute of Neurolog, Tbilisi, Georgia.
LA  - eng
PT  - Journal Article
PL  - Georgia (Republic)
TA  - Georgian Med News
JT  - Georgian medical news
JID - 101218222
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Anthropometry
MH  - Comorbidity
MH  - Diabetes Mellitus, Type 2/*blood/epidemiology
MH  - Glycated Hemoglobin/*analysis
MH  - Humans
MH  - Prospective Studies
MH  - Sleep Apnea, Obstructive/*blood/epidemiology
MH  - Vascular Endothelial Growth Factor A/*blood
EDAT- 2018/12/06 06:00
MHDA- 2019/04/16 06:00
CRDT- 2018/12/06 06:00
PHST- 2018/12/06 06:00 [entrez]
PHST- 2018/12/06 06:00 [pubmed]
PHST- 2019/04/16 06:00 [medline]
PST - ppublish
SO  - Georgian Med News. 2018 Oct;(283):55-58.