PMID- 30518027
OWN - NLM
STAT- MEDLINE
DCOM- 20190329
LR  - 20200225
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 19
IP  - 12
DP  - 2018 Dec 4
TI  - A Promising Biocompatible Platform: Lipid-Based and Bio-Inspired Smart Drug 
      Delivery Systems for Cancer Therapy.
LID - 10.3390/ijms19123859 [doi]
LID - 3859
AB  - Designing new drug delivery systems (DDSs) for safer cancer therapy during 
      pre-clinical and clinical applications still constitutes a considerable 
      challenge, despite advances made in related fields. Lipid-based drug delivery 
      systems (LBDDSs) have emerged as biocompatible candidates that overcome many 
      biological obstacles. In particular, a combination of the merits of lipid 
      carriers and functional polymers has maximized drug delivery efficiency. 
      Functionalization of LBDDSs enables the accumulation of anti-cancer drugs at 
      target destinations, which means they are more effective at controlled drug 
      release in tumor microenvironments (TMEs). This review highlights the various 
      types of ligands used to achieve tumor-specific delivery and discusses the 
      strategies used to achieve the effective release of drugs in TMEs and not into 
      healthy tissues. Moreover, innovative recent designs of LBDDSs are also 
      described. These smart systems offer great potential for more advanced cancer 
      therapies that address the challenges posed in this research area.
FAU - Kim, Min Woo
AU  - Kim MW
AUID- ORCID: 0000-0002-5886-099X
AD  - International Research Organization for Advanced Science and Technology (IROAST), 
      Kumamoto University, Kumamoto 860-8555, Japan. minwoo-kim@kumamoto-u.ac.jp.
FAU - Kwon, Seung-Hae
AU  - Kwon SH
AD  - Division of Bio-imaging, Chuncheon Center, Korea Basic Science Institute (KBSI), 
      Chuncheon 24341, Korea. kwonsh@kbsi.re.kr.
FAU - Choi, Jung Hoon
AU  - Choi JH
AD  - Department of Anatomy, College of Veterinary Medicine, Kangwon National 
      University, Chuncheon 24341, Korea. jhchoi@kangwon.ac.kr.
FAU - Lee, Aeju
AU  - Lee A
AUID- ORCID: 0000-0002-4925-1156
AD  - International Research Organization for Advanced Science and Technology (IROAST), 
      Kumamoto University, Kumamoto 860-8555, Japan. aeju-lee@kumamoto-u.ac.jp.
AD  - Magnesium Research Center, Kumamoto University, Kumamoto 860-8555, Japan. 
      aeju-lee@kumamoto-u.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20181204
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Biocompatible Materials)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Lipids)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/*chemistry
MH  - Biomimetics/*methods
MH  - Delayed-Action Preparations/therapeutic use
MH  - *Drug Delivery Systems
MH  - Humans
MH  - Lipids/*chemistry
MH  - Neoplasms/*drug therapy
PMC - PMC6321581
OTO - NOTNLM
OT  - biomimetics
OT  - cancer therapy
OT  - controlled release
OT  - functionalization
OT  - lipid-based drug delivery systems
COIS- The authors declare no conflict of interest.
EDAT- 2018/12/07 06:00
MHDA- 2019/03/30 06:00
PMCR- 2018/12/01
CRDT- 2018/12/07 06:00
PHST- 2018/11/13 00:00 [received]
PHST- 2018/11/29 00:00 [revised]
PHST- 2018/12/02 00:00 [accepted]
PHST- 2018/12/07 06:00 [entrez]
PHST- 2018/12/07 06:00 [pubmed]
PHST- 2019/03/30 06:00 [medline]
PHST- 2018/12/01 00:00 [pmc-release]
AID - ijms19123859 [pii]
AID - ijms-19-03859 [pii]
AID - 10.3390/ijms19123859 [doi]
PST - epublish
SO  - Int J Mol Sci. 2018 Dec 4;19(12):3859. doi: 10.3390/ijms19123859.