PMID- 30518248
OWN - NLM
STAT- MEDLINE
DCOM- 20190429
LR  - 20190429
IS  - 1465-3338 (Electronic)
IS  - 0307-9457 (Linking)
VI  - 48
IP  - 2
DP  - 2019 Apr
TI  - Induction of IBV strain-specific neutralizing antibodies and broad spectrum 
      protection in layer pullets primed with IBV Massachusetts (Mass) and 793B 
      vaccines prior to injection of inactivated vaccine containing Mass antigen.
PG  - 135-147
LID - 10.1080/03079457.2018.1556778 [doi]
AB  - In an initial study in specified pathogen free (SPF) chickens, a heterologous 
      virus neutralizing (VN) antibody response to IBV variants Q1, Variant 2 (Var 2), 
      D388/QX (D388), D274 and Arkansas (DPI) was observed using a vaccination 
      programme incorporating two different live-attenuated IBV vaccines, followed by 
      boosting with an inactivated vaccine containing IBV Massachusetts (Mass) antigen. 
      Therefore, a more detailed study was undertaken in SPF layer-type chickens primed 
      with IBV Mass and 793B vaccines. The efficacy of single or repeated vaccination 
      with a multivalent inactivated vaccine containing IBV antigen was determined 
      against challenge with five virulent IBVs: Mass (M41), 793B (4/91), D388, Q1 and 
      Var 2. The parameters assessed were serological response, respiratory signs, egg 
      production, post mortem abnormalities in the reproductive organs and abdomen, and 
      incidence of IBV antigen in kidneys. Increased VN titres were recorded against 
      the five IBV challenge strains, with a significantly higher level of protection 
      against drops in egg production following challenge. The difference between one 
      or two vaccinations with inactivated vaccine was not significant in terms of egg 
      production. However, a significantly increased level of protection was seen in 
      the lower percentage of hens with free yolk in the abdomen and/or peritonitis 
      post challenge with IBV variants, D388, Q1 and Var 2 not included in the 
      vaccination programme. A lower incidence of acute, degenerated ovaries was found 
      in groups given one injection of inactivated vaccine following live priming, and 
      this was significantly lower than in groups given only live priming.
FAU - de Wit, J J Sjaak
AU  - de Wit JJS
AD  - a GD Animal Health Deventer , Netherlands.
FAU - Malo, Aris
AU  - Malo A
AD  - b Boehringer Ingelheim Vetmedica GmbH Ingelheim am 8 Rhein , Germany.
FAU - Cook, Jane K A
AU  - Cook JKA
AD  - c 138 Hartford Road, Huntingdon, Cambridgeshire PE29 1XQ , UK.
LA  - eng
PT  - Journal Article
DEP - 20190104
PL  - England
TA  - Avian Pathol
JT  - Avian pathology : journal of the W.V.P.A
JID - 8210638
RN  - 0 (Antibodies, Neutralizing)
RN  - 0 (Antibodies, Viral)
RN  - 0 (Vaccines, Attenuated)
RN  - 0 (Vaccines, Inactivated)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Antibodies, Neutralizing/biosynthesis
MH  - Antibodies, Viral/biosynthesis
MH  - *Chickens
MH  - Coronavirus Infections/prevention & control/*veterinary/virology
MH  - Female
MH  - Infectious bronchitis virus/*immunology
MH  - Poultry Diseases/*prevention & control/virology
MH  - Specific Pathogen-Free Organisms
MH  - Vaccination/*veterinary
MH  - Vaccines, Attenuated/immunology
MH  - Vaccines, Inactivated/immunology
MH  - Viral Vaccines/*immunology
OTO - NOTNLM
OT  - IB variants
OT  - Infectious bronchitis
OT  - layer abnormalities
OT  - protection
OT  - vaccines
OT  - virus neutralization
EDAT- 2018/12/07 06:00
MHDA- 2019/04/30 06:00
CRDT- 2018/12/07 06:00
PHST- 2018/12/07 06:00 [pubmed]
PHST- 2019/04/30 06:00 [medline]
PHST- 2018/12/07 06:00 [entrez]
AID - 10.1080/03079457.2018.1556778 [doi]
PST - ppublish
SO  - Avian Pathol. 2019 Apr;48(2):135-147. doi: 10.1080/03079457.2018.1556778. Epub 
      2019 Jan 4.