PMID- 30518300 OWN - NLM STAT- MEDLINE DCOM- 20190423 LR - 20190423 IS - 1933-7205 (Electronic) IS - 1933-7191 (Linking) VI - 26 IP - 2 DP - 2019 Feb TI - The Disease Phenotype of Adenomyosis-Affected Women Correlates With Specific Serum Cytokine Profiles. PG - 198-206 LID - 10.1177/1933719118816852 [doi] AB - BACKGROUND: Adenomyosis (ADE) is an enigmatic uterine disorder. Several types have been previously described: diffuse adenomyosis (DIF-ADE), focal adenomyosis (FOC-ADE), and association of focal and diffuse lesions (FOC/DIF-ADE). Abnormal immune phenomena have been described that may provide an understanding of the pathophysiology of adenomyosis. However, the immune imbalance in adenomyosis is however still poorly understood. OBJECTIVE: To compare serum cytokine profiles for the various adenomyosis phenotypes in adenomyosis versus disease-free women. MATERIALS AND METHODS: This cohort study included 80 women. Based on the magnetic resonance imaging (MRI) findings, the women were allocated to the ADE group (n = 60) and the control group (n = 20). The ADE group was further subdivided according to the phenotype: DIF-ADE, FOC-ADE, and FOC/DIF-ADE. For all of the women, serum cytokine levels were assayed by multiplex immunoassay. RESULTS: Serum levels of interleukin (IL) 23 (237.77 pg/mL +/- 70.97 in the ADE-group versus 1855.04 +/- 1411.33 in the control group, P = .019), IL25 (31.98 +/- 8.54 vs 222.08 +/- 170.90, respectively, P = .006), IL31 (10.13 +/- 3.83 vs 91.51 +/- 71.21, respectively, P = .034), IL33 (3.77 +/- 1.23 vs 17.86 +/- 11.49, respectively, P = .016), and IL17F (16.29 +/- 2.35 vs 30.12 +/- 8.29, respectively, P = .042) were significantly lower in the women with adenomyosis when compared to the controls In the FOC/DIF-ADE group, the serum levels of IL23, IL31, IL25, and IL33 were significantly lower when compared to the control group. CONCLUSION: Serum levels of IL23, IL31, IL25, and IL33 were lower in women exhibiting adenomyosis forms with associated diffuse and focal lesions when compared with controls. The pathogenesis of adenomyosis may be associated with an immunotolerant process that is more pronounced in associated FOC/DIF-ADE. FAU - Bourdon, Mathilde AU - Bourdon M AD - 1 Department of Gynaecology Obstetrics II and Reproductive Medicine, Faculte de Medecine, Universite Paris Descartes, Sorbonne Paris Cite, Assistance Publique-Hopitaux de Paris (AP-HP), Hopital Universitaire Paris Centre, Centre Hospitalier Universitaire (CHU) Cochin, Paris, France. AD - 2 Department "Development, Reproduction and Cancer", Institut Cochin, Universite Paris Descartes, Sorbonne Paris Cite, Paris, France. FAU - Santulli, Pietro AU - Santulli P AD - 1 Department of Gynaecology Obstetrics II and Reproductive Medicine, Faculte de Medecine, Universite Paris Descartes, Sorbonne Paris Cite, Assistance Publique-Hopitaux de Paris (AP-HP), Hopital Universitaire Paris Centre, Centre Hospitalier Universitaire (CHU) Cochin, Paris, France. AD - 2 Department "Development, Reproduction and Cancer", Institut Cochin, Universite Paris Descartes, Sorbonne Paris Cite, Paris, France. FAU - Chouzenoux, Sandrine AU - Chouzenoux S AD - 2 Department "Development, Reproduction and Cancer", Institut Cochin, Universite Paris Descartes, Sorbonne Paris Cite, Paris, France. FAU - Maignien, Chloe AU - Maignien C AD - 1 Department of Gynaecology Obstetrics II and Reproductive Medicine, Faculte de Medecine, Universite Paris Descartes, Sorbonne Paris Cite, Assistance Publique-Hopitaux de Paris (AP-HP), Hopital Universitaire Paris Centre, Centre Hospitalier Universitaire (CHU) Cochin, Paris, France. FAU - Bailly, Karine AU - Bailly K AD - 3 Institut Cochin, Plateforme de Cytometrie et d'Immuno-Biologie (CYBIO), Universite Paris Descartes, Sorbonne Paris Cite, Paris, France. FAU - Andrieu, Muriel AU - Andrieu M AD - 3 Institut Cochin, Plateforme de Cytometrie et d'Immuno-Biologie (CYBIO), Universite Paris Descartes, Sorbonne Paris Cite, Paris, France. FAU - Millischer, Anne-Elodie AU - Millischer AE AD - 4 Centre de Radiologie Bachaumont, IMPC, Paris, France. FAU - Doridot, Ludivine AU - Doridot L AD - 2 Department "Development, Reproduction and Cancer", Institut Cochin, Universite Paris Descartes, Sorbonne Paris Cite, Paris, France. FAU - Marcellin, Louis AU - Marcellin L AD - 1 Department of Gynaecology Obstetrics II and Reproductive Medicine, Faculte de Medecine, Universite Paris Descartes, Sorbonne Paris Cite, Assistance Publique-Hopitaux de Paris (AP-HP), Hopital Universitaire Paris Centre, Centre Hospitalier Universitaire (CHU) Cochin, Paris, France. AD - 2 Department "Development, Reproduction and Cancer", Institut Cochin, Universite Paris Descartes, Sorbonne Paris Cite, Paris, France. FAU - Batteux, Frederic AU - Batteux F AD - 2 Department "Development, Reproduction and Cancer", Institut Cochin, Universite Paris Descartes, Sorbonne Paris Cite, Paris, France. FAU - Chapron, Charles AU - Chapron C AD - 1 Department of Gynaecology Obstetrics II and Reproductive Medicine, Faculte de Medecine, Universite Paris Descartes, Sorbonne Paris Cite, Assistance Publique-Hopitaux de Paris (AP-HP), Hopital Universitaire Paris Centre, Centre Hospitalier Universitaire (CHU) Cochin, Paris, France. AD - 2 Department "Development, Reproduction and Cancer", Institut Cochin, Universite Paris Descartes, Sorbonne Paris Cite, Paris, France. LA - eng PT - Journal Article DEP - 20181205 PL - United States TA - Reprod Sci JT - Reproductive sciences (Thousand Oaks, Calif.) JID - 101291249 RN - 0 (Cytokines) SB - IM MH - Adenomyosis/*blood/diagnostic imaging MH - Adult MH - Cytokines/*blood MH - Endometrium/*diagnostic imaging MH - Female MH - Humans MH - Magnetic Resonance Imaging MH - Myometrium/*diagnostic imaging MH - Phenotype MH - Young Adult OTO - NOTNLM OT - IL17F OT - IL23 OT - IL25 OT - IL31 OT - IL33 OT - adenomyosis OT - cytokine profiles OT - pathogenesis EDAT- 2018/12/07 06:00 MHDA- 2019/04/24 06:00 CRDT- 2018/12/07 06:00 PHST- 2018/12/07 06:00 [pubmed] PHST- 2019/04/24 06:00 [medline] PHST- 2018/12/07 06:00 [entrez] AID - 10.1177/1933719118816852 [doi] PST - ppublish SO - Reprod Sci. 2019 Feb;26(2):198-206. doi: 10.1177/1933719118816852. Epub 2018 Dec 5.