PMID- 30520409
OWN - NLM
STAT- MEDLINE
DCOM- 20200805
LR  - 20221207
IS  - 1469-8978 (Electronic)
IS  - 0033-2917 (Linking)
VI  - 49
IP  - 15
DP  - 2019 Nov
TI  - Effect of selective serotonin reuptake inhibitor on prefrontal-striatal 
      connectivity is dependent on the level of TNF-alpha in patients with major depressive 
      disorder.
PG  - 2608-2616
LID - 10.1017/S0033291718003616 [doi]
AB  - BACKGROUND: We hypothesize that the tumor necrosis factor-alpha (TNF-alpha) may play a 
      role in disturbing the effect of selective serotonin reuptake inhibitor (SSRI) on 
      the striatal connectivity in patients with major depressive disorder (MDD). 
      METHODS: We performed a longitudinal observation by combining resting-state 
      functional magnetic resonance imaging (rs-fMRI) and biochemical analyses to 
      identify the abnormal striatal connectivity in MDD patients, and to evaluate the 
      effect of TNF-alpha level on these abnormal connectivities during SSRI treatment. 
      Eighty-five rs-fMRI scans were collected from 25 MDD patients and 35 healthy 
      controls, and the scans were repeated for all the patients before and after a 
      6-week SSRI treatment. Whole-brain voxel-wise functional connectivity (FC) was 
      calculated by correlating the rs-fMRI time courses between each voxel and the 
      striatal seeds (i.e. spherical regions placed at the striatums). The level of 
      TNF-alpha in serum was evaluated by Milliplex assay. Factorial analysis was performed 
      to assess the interaction effects of 'TNF-alpha x treatment' in the regions with 
      between-group FC difference. RESULTS: Compared with controls, MDD patients showed 
      significantly higher striatal FC in the medial prefrontal cortex (MPFC) and 
      bilateral middle/superior temporal cortices before SSRI treatment (p < 0.001, 
      uncorrected). Moreover, a significant interaction effect of 'TNF-alpha x treatment' 
      was found in MPFC-striatum FC in MDD patients (p = 0.002), and the significance 
      remained after adjusted for age, gender, head motion, and episode of disease. 
      CONCLUSION: These findings provide evidence that treatment-related brain 
      connectivity change is dependent on the TNF-alpha level in MDD patients, and the 
      MPFC-striatum connectivities possibly serve as an important target in the brain.
FAU - Liu, Kai
AU  - Liu K
AD  - School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 
      China.
AD  - Medical Imaging Department, Nanfang Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Zhao, Xiaohua
AU  - Zhao X
AD  - School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 
      China.
FAU - Lu, Xiaobing
AU  - Lu X
AD  - The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai 
      Hospital), Guangzhou, China.
FAU - Zhu, Xiaoxia
AU  - Zhu X
AD  - School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 
      China.
FAU - Chen, Hui
AU  - Chen H
AD  - Medical Imaging Department, Nanfang Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Wang, Mengmeng
AU  - Wang M
AD  - School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 
      China.
FAU - Yan, Weixin
AU  - Yan W
AD  - School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 
      China.
FAU - Jing, Linlin
AU  - Jing L
AD  - TCM Integrated Hospital of Southern Medical University, Southern Medical 
      University, Guangzhou, China.
FAU - Deng, Yanjia
AU  - Deng Y
AD  - Medical Imaging Department, Nanfang Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Yu, Lin
AU  - Yu L
AD  - The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai 
      Hospital), Guangzhou, China.
FAU - Wu, Huawang
AU  - Wu H
AD  - The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai 
      Hospital), Guangzhou, China.
FAU - Wen, Ge
AU  - Wen G
AD  - Medical Imaging Department, Nanfang Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Sun, Xuegang
AU  - Sun X
AD  - School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 
      China.
AD  - Key Laboratory of Ministry of Education for TCM Viscera-State Theory and 
      Applications, Liaoning University of Traditional Chinese Medicine, Shenyang, 
      China.
FAU - Lv, Zhiping
AU  - Lv Z
AUID- ORCID: 0000-0003-0025-8098
AD  - School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 
      China.
LA  - eng
SI  - ChiCTR/ChiCTR-IPR-14005427
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20181206
PL  - England
TA  - Psychol Med
JT  - Psychological medicine
JID - 1254142
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Brain Mapping
MH  - Case-Control Studies
MH  - Corpus Striatum/*physiopathology
MH  - Depressive Disorder, Major/blood/drug therapy/*physiopathology
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Prefrontal Cortex/*physiopathology
MH  - Rest
MH  - Selective Serotonin Reuptake Inhibitors/*pharmacology
MH  - Tumor Necrosis Factor-alpha/*blood
MH  - Young Adult
OTO - NOTNLM
OT  - Major depressive disorder
OT  - resting-state functional connectivity
OT  - selective serotonin reuptake inhibitor
OT  - striatum
OT  - tumor necrosis factor-alpha
EDAT- 2018/12/07 06:00
MHDA- 2020/08/06 06:00
CRDT- 2018/12/07 06:00
PHST- 2018/12/07 06:00 [pubmed]
PHST- 2020/08/06 06:00 [medline]
PHST- 2018/12/07 06:00 [entrez]
AID - S0033291718003616 [pii]
AID - 10.1017/S0033291718003616 [doi]
PST - ppublish
SO  - Psychol Med. 2019 Nov;49(15):2608-2616. doi: 10.1017/S0033291718003616. Epub 2018 
      Dec 6.