PMID- 30520523
OWN - NLM
STAT- MEDLINE
DCOM- 20190207
LR  - 20210109
IS  - 1939-1676 (Electronic)
IS  - 0891-6640 (Print)
IS  - 0891-6640 (Linking)
VI  - 33
IP  - 1
DP  - 2019 Jan
TI  - Allergen-specific immunoglobulin E in sera of horses affected with insect bite 
      hypersensitivity, severe equine asthma or both conditions.
PG  - 266-274
LID - 10.1111/jvim.15355 [doi]
AB  - BACKGROUND: Genetic, epidemiologic, and clinical evidence suggests that, in 
      horses, there are manifestations of hypersensitivity that can occur together. 
      OBJECTIVES: To investigate whether concurrent insect bite hypersensitivity (IBH) 
      and severe equine asthma (EA) is associated with higher allergen-specific and 
      total serum immunoglobulin E (IgE) concentrations than only EA or IBH. ANIMALS: 
      Healthy control horses (C, n = 40), horses with IBH (IBH, n = 24), severe EA (EA, 
      n = 18), and both conditions (IBH/EA, n = 23) were included. METHODS: In our 
      retrospective comparative study, sera from horses with signs of severe EA, IBH, 
      and control animals were used. IgE specific for 15 recombinant (r) allergens as 
      well as total serum IgE concentrations were measured by enzyme-linked 
      immunosorbent assay. RESULTS: Group IBH (median sum r-Culicoides IgE: optical 
      density at 405 nm [OD(405) ] = 3.54 [0.48-15.07]) and group IBH/EA (OD(405) 
       = 4.55 [0.46-17.15]) had significantly (P < .001) higher IgE against Culicoides 
      r-allergens than groups C (OD(405)  = 0.44 [0.21-2.05]) and EA (OD(405)  = 0.6 
      [0.2-2.9]). There were no significant (P > .05) differences between group IBH and 
      group IBH/EA. No significant differences among the groups were found for the 
      other r-allergens or total serum IgE concentration. Compared to controls, horses 
      with severe IBH had significantly increased IgE concentration to 5 Culicoides 
      r-allergens (P < .05), whereas horses with moderate IBH had significantly 
      increased IgE concentration to only 3 Culicoides r-allergens (P < .05). 
      CONCLUSIONS AND CLINICAL IMPORTANCE: Susceptibility of IBH-affected horses to 
      develop EA is likely not associated with IgE-mediated immune reactions but with 
      other immunopathological mechanisms.
CI  - (c) 2018 The Authors. Journal of Veterinary Internal Medicine published by Wiley 
      Periodicals, Inc. on behalf of the American College of Veterinary Internal 
      Medicine.
FAU - Verdon, Maeva
AU  - Verdon M
AUID- ORCID: 0000-0001-7950-1331
AD  - Equine clinic, Swiss Institute of Equine Medicine, University of Bern and 
      Agroscope, Berne, Switzerland.
FAU - Lanz, Simone
AU  - Lanz S
AUID- ORCID: 0000-0003-2453-1829
AD  - Equine clinic, Swiss Institute of Equine Medicine, University of Bern and 
      Agroscope, Berne, Switzerland.
FAU - Rhyner, Claudio
AU  - Rhyner C
AUID- ORCID: 0000-0002-7557-9171
AD  - Department of Vaccine Development, Swiss Institute of Allergy and Asthma Research 
      (SIAF), University of Zurich, Davos, Switzerland.
FAU - Gerber, Vinzenz
AU  - Gerber V
AUID- ORCID: 0000-0002-7834-4482
AD  - Equine clinic, Swiss Institute of Equine Medicine, University of Bern and 
      Agroscope, Berne, Switzerland.
FAU - Marti, Eliane
AU  - Marti E
AUID- ORCID: 0000-0003-1284-4350
AD  - Department of Clinical Research, University of Bern, Berne, Switzerland.
LA  - eng
GR  - Account : 39-890/Institut Suisse de Medecine Equine/
GR  - 310030-160196 and/Schweizerischer Nationalfonds zur Forderung der 
      Wissenschaftlichen Forschung/
GR  - 131003A162548/1/Schweizerischer Nationalfonds zur Forderung der 
      Wissenschaftlichen Forschung/
PT  - Journal Article
DEP - 20181206
PL  - United States
TA  - J Vet Intern Med
JT  - Journal of veterinary internal medicine
JID - 8708660
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/*immunology
MH  - Animals
MH  - Asthma/blood/immunology/*veterinary
MH  - Case-Control Studies
MH  - Ceratopogonidae/immunology
MH  - Female
MH  - Horse Diseases/blood/*immunology
MH  - Horses
MH  - Hypersensitivity/blood/immunology/*veterinary
MH  - Immunoglobulin E/*blood/immunology
MH  - Insect Bites and Stings/blood/immunology/*veterinary
MH  - Male
MH  - Retrospective Studies
PMC - PMC6335542
OTO - NOTNLM
OT  - equine asthma
OT  - horse
OT  - immunoglobulin E
OT  - insect bite hypersensitivity
OT  - multiple equine allergies
EDAT- 2018/12/07 06:00
MHDA- 2019/02/08 06:00
PMCR- 2019/01/01
CRDT- 2018/12/07 06:00
PHST- 2018/05/02 00:00 [received]
PHST- 2018/10/10 00:00 [accepted]
PHST- 2018/12/07 06:00 [pubmed]
PHST- 2019/02/08 06:00 [medline]
PHST- 2018/12/07 06:00 [entrez]
PHST- 2019/01/01 00:00 [pmc-release]
AID - JVIM15355 [pii]
AID - 10.1111/jvim.15355 [doi]
PST - ppublish
SO  - J Vet Intern Med. 2019 Jan;33(1):266-274. doi: 10.1111/jvim.15355. Epub 2018 Dec 
      6.