PMID- 30521631
OWN - NLM
STAT- MEDLINE
DCOM- 20190516
LR  - 20200309
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 12
DP  - 2018
TI  - Association of colorectal polyps and cancer with low-dose persistent organic 
      pollutants: A case-control study.
PG  - e0208546
LID - 10.1371/journal.pone.0208546 [doi]
LID - e0208546
AB  - BACKGROUND: Low-dose persistent organic pollutants (POPs) have recently been 
      linked to immunosenescence, a key mechanism in carcinogenesis, as well as many 
      aging-related chronic diseases. Since feces are the main excretion route of POPs, 
      the large intestine is a potential target organ for these pollutants. We 
      performed a case-control study to evaluate whether exposure to low-dose POPs is 
      related to the risk of colorectal polyps and cancer. METHODS: A total of 277 
      participants were recruited from one hospital: 99 cancer patients, 102 polyp 
      patients, and 76 control subjects. As typical examples of POPs, we measured the 
      serum concentrations of organochlorine pesticides (OCPs) and polychlorinated 
      biphenyls (PCBs). RESULTS: Across the tertiles of the summary measure of POPs, 
      the adjusted odds ratios (ORs) of colorectal polyps and cancer were 2.8 (1.2-6.8) 
      (Ptrend = 0.01) and 3.0 (1.0-8.8) (Ptrend = 0.02), respectively, for subjects in 
      the highest tertile. When OCPs and PCBs were analyzed separately, OCPs were 
      linked to an increased risk of both polyps and cancer; the adjusted ORs were 2.3 
      (0.9-5.7) (Ptrend = 0.05) for polyps and 3.6 (1.1-11.8) (Ptrend< 0.01) for 
      cancer. However, PCBs were only significantly associated with a high risk of 
      polyps but not cancer; the adjusted OR was 2.8 (1.2-6.6) (Ptrend = 0.01). 
      CONCLUSION: Chronic exposure to low-dose POPs may be associated with an increased 
      risk of colorectal polyps and cancer. Our findings suggest the carcinogenic 
      potential of strong lipophilic chemical mixtures such as POPs which are 
      accumulated in adipose tissue, released to circulation, and eliminated through 
      feces.
FAU - Lee, Yu-Mi
AU  - Lee YM
AUID- ORCID: 0000-0003-3206-7894
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, Daegu, Republic of Korea.
FAU - Kim, Se-A
AU  - Kim SA
AD  - Department of Biomedical Science, Graduate School, Kyungpook National University, 
      Daegu, Republic of Korea.
AD  - BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science, 
      Kyungpook National University, Daegu, Republic of Korea.
FAU - Choi, Gyu-Seog
AU  - Choi GS
AD  - Department of Surgery, School of Medicine, Kyungpook National University, Daegu, 
      Republic of Korea.
FAU - Park, Soo-Yeun
AU  - Park SY
AD  - Department of Surgery, School of Medicine, Kyungpook National University, Daegu, 
      Republic of Korea.
FAU - Jeon, Seong Woo
AU  - Jeon SW
AUID- ORCID: 0000-0002-9539-9389
AD  - Department of Internal Medicine, School of Medicine, Kyungpook National 
      University, Daegu, Republic of Korea.
FAU - Lee, Hyun Seok
AU  - Lee HS
AUID- ORCID: 0000-0001-9288-0321
AD  - Department of Internal Medicine, School of Medicine, Kyungpook National 
      University, Daegu, Republic of Korea.
FAU - Lee, Su-Jin
AU  - Lee SJ
AD  - Graduate School of Department of Public Health, Kyungpook National University, 
      Daegu, Republic of Korea.
FAU - Heo, Somi
AU  - Heo S
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, Daegu, Republic of Korea.
FAU - Lee, Duk-Hee
AU  - Lee DH
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, Daegu, Republic of Korea.
AD  - BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science, 
      Kyungpook National University, Daegu, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181206
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Colonic Polyps/*chemically induced
MH  - Colorectal Neoplasms/*chemically induced
MH  - Environmental Exposure/*adverse effects
MH  - Environmental Pollutants/blood/*toxicity
MH  - Female
MH  - Gas Chromatography-Mass Spectrometry
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Republic of Korea
MH  - Risk Factors
PMC - PMC6283632
COIS- The authors declare no potential conflicts of interest.
EDAT- 2018/12/07 06:00
MHDA- 2019/05/17 06:00
PMCR- 2018/12/06
CRDT- 2018/12/07 06:00
PHST- 2018/08/16 00:00 [received]
PHST- 2018/11/19 00:00 [accepted]
PHST- 2018/12/07 06:00 [entrez]
PHST- 2018/12/07 06:00 [pubmed]
PHST- 2019/05/17 06:00 [medline]
PHST- 2018/12/06 00:00 [pmc-release]
AID - PONE-D-18-24170 [pii]
AID - 10.1371/journal.pone.0208546 [doi]
PST - epublish
SO  - PLoS One. 2018 Dec 6;13(12):e0208546. doi: 10.1371/journal.pone.0208546. 
      eCollection 2018.