PMID- 30522175
OWN - NLM
STAT- MEDLINE
DCOM- 20190226
LR  - 20190226
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 47
IP  - 12
DP  - 2018 Dec 8
TI  - [Clinicopathologic and molecular features of myoepithelial tumors of salivary 
      glands].
PG  - 936-940
LID - 10.3760/cma.j.issn.0529-5807.2018.12.008 [doi]
AB  - Objective: To investigate the clinicopathological, and molecular characteristics 
      of myoepithelial tumors (MTs) of salivary glands. Methods: A total of 37 MTs 
      cases including 13 malignant epithelial tumors (MMTs) and 24 benign epithelial 
      tumors (BMTs) of salivary glands were identified from the archives of the 
      Department of Pathology, General Hospital of Eastern Theater Command, dating from 
      2006 to 2016. Clinical features, histological patterns, immunohistochemical 
      characteristics and status of EWSR1 gene rearrangement by fluorescence in situ 
      hybridization (FISH) analysis were reviewed in all cases. Results: Clinically, 37 
      MTs cases mainly occurred in the parotid glands, when most of the patients 
      presented with painless masses. Of the 13 MMTs cases, male to female ratio was 
      7ratio6, and the median age was 62 years old. Of the 24 BMTs cases, male to female 
      ratio was 5ratio7, and the median age was 54 years old. Immunohistochemically, 37 MTs 
      cases were positive for CKpan, and at least one myoepithelial marker. Twenty six 
      of 37 MTs cases were analyzable for the EWSR1 gene break by FISH. Based on the 
      previous evaluation criterion, the EWSR1 translocation was detected in 4 cases of 
      11 MMTs, and 4 cases of 15 BMTs. According to the main histological composition 
      of tumor cells, 4 EWSR1-positive MMTs covered 2 clear-cell cases and 2 
      epithelioid-cell cases, when 4 EWSR1-positive BMTs covered 2 clear-cell cases, 1 
      plasmacytoid-cell case, and 1 spindle-cell case. Conclusions: Males and females 
      are affected equally. MTs express immunoreactivity for CKpan, and at least one 
      myoepithelial marker. The EWSR1 rearrangement is present in a subset of MTs, with 
      variable morphological characteristics, and has no statistical significance on 
      clinical behavior.
FAU - Ni, H
AU  - Ni H
AD  - Department of Pathology, General Hospital of Eastern Theater Command, Nanjing 
      210002, China.
FAU - Wu, N
AU  - Wu N
FAU - Wang, X T
AU  - Wang XT
FAU - Xia, Q Y
AU  - Xia QY
FAU - Wang, X
AU  - Wang X
FAU - Shi, S S
AU  - Shi SS
FAU - Li, R
AU  - Li R
FAU - Zhou, X J
AU  - Zhou XJ
FAU - Rao, Q
AU  - Rao Q
LA  - chi
GR  - 81372743/National Natural Science Foundation of China/
GR  - 81101933/National Natural Science Youth Science Foundation/
GR  - BK2010463/Jiangsu Natural Science Foundation/
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (EWSR1 protein, human)
RN  - 0 (RNA-Binding Protein EWS)
RN  - EC 2.7.3.2 (Creatine Kinase)
SB  - IM
MH  - Biomarkers, Tumor
MH  - Creatine Kinase/analysis
MH  - Female
MH  - Gene Rearrangement
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - *Myoepithelioma/chemistry/genetics/pathology
MH  - *Parotid Neoplasms/chemistry/genetics/pathology
MH  - RNA-Binding Protein EWS/genetics
MH  - Salivary Gland Neoplasms/chemistry/genetics/pathology
OTO - NOTNLM
OT  - Immunohistochemistry
OT  - Myoepithelioma
OT  - Salivary gland neoplasms
EDAT- 2018/12/14 06:00
MHDA- 2019/02/27 06:00
CRDT- 2018/12/08 06:00
PHST- 2018/12/08 06:00 [entrez]
PHST- 2018/12/14 06:00 [pubmed]
PHST- 2019/02/27 06:00 [medline]
AID - 10.3760/cma.j.issn.0529-5807.2018.12.008 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2018 Dec 8;47(12):936-940. doi: 
      10.3760/cma.j.issn.0529-5807.2018.12.008.