PMID- 30523571
OWN - NLM
STAT- MEDLINE
DCOM- 20191224
LR  - 20191224
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 191
IP  - 1
DP  - 2019 Sep
TI  - An Antagonism Joint Action of Lead and Di-2-Ethylhexyl Phthalate Explains an 
      Improved Ability of Learning and Memory after Combined Exposure in Weaning Rats.
PG  - 126-134
LID - 10.1007/s12011-018-1586-5 [doi]
AB  - Lead and di-2-ethylhexyl phthalate (DEHP) are widely distributed in the 
      environment, and their neurotoxicity has caused a widespread concern. The 
      complexity of environmental exposure provides the possibility of their combined 
      exposure. The present study aims to describe a joint neurotoxicity and clarify 
      the potential mechanism after combined exposure to lead and DEHP. A 2 x 3 
      factorial design was used to analyze either single effects or their interaction 
      by a subchronic lead and DEHP exposure model of the male weaning rats. Similar to 
      the previous study, lead or DEHP single exposure showed an increased 
      neurotoxicity. Interestingly, our neurobehavioral test showed the rats in the 
      combined exposure groups had a better ability of learning and memory compared 
      with the single-exposure ones. It seemed to reflect an antagonism joint action in 
      neurotoxicity after combined exposure. The content of dehydroepiandrosterone 
      (DHEA) in serum and the mRNA level of brain-derived neurotrophic factor (Bdnf) in 
      the hippocampus showed a similar trend to the ability of learning and memory. 
      However, there was insufficient evidence to support the joint action on some 
      indexes of oxidative stress such as malondialdehyde (MDA), the ratio of reduced 
      glutathione(GSH) to oxidized glutathione(GSSG), gammaglutamylcysteine synthetase 
      (gamma-GCS), glutathione-s transferase (GST), and nuclear factor E2-related factor 2 
      (Nrf2) mRNA expression in the hippocampus. In a word, our current study reminded 
      a unique antagonism joint action of neurotoxicity after combined exposure to lead 
      and DEHP, which may contribute to understanding some shallow mechanism of the 
      joint toxicity due to the complexity of environmental pollutant exposure.
FAU - Li, Liuli
AU  - Li L
AD  - Department of Toxicology, School of Public Health, China Medical University, 
      No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning Province, 
      People's Republic of China.
FAU - Li, Hao
AU  - Li H
AD  - Department of Toxicology, School of Public Health, China Medical University, 
      No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning Province, 
      People's Republic of China.
FAU - Qu, Peng
AU  - Qu P
AD  - Department of Toxicology, School of Public Health, China Medical University, 
      No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning Province, 
      People's Republic of China.
FAU - Xiao, Mingyang
AU  - Xiao M
AD  - Department of Toxicology, School of Public Health, China Medical University, 
      No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning Province, 
      People's Republic of China.
FAU - Zhang, Guopei
AU  - Zhang G
AD  - Department of Toxicology, School of Public Health, China Medical University, 
      No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning Province, 
      People's Republic of China.
FAU - Zhang, Qianye
AU  - Zhang Q
AD  - Department of Toxicology, School of Public Health, China Medical University, 
      No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning Province, 
      People's Republic of China.
FAU - Cai, Yuan
AU  - Cai Y
AD  - Department of Toxicology, School of Public Health, China Medical University, 
      No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning Province, 
      People's Republic of China.
FAU - Jin, Cuihong
AU  - Jin C
AD  - Department of Toxicology, School of Public Health, China Medical University, 
      No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning Province, 
      People's Republic of China.
FAU - Yang, Jinghua
AU  - Yang J
AD  - Department of Toxicology, School of Public Health, China Medical University, 
      No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning Province, 
      People's Republic of China.
FAU - Wu, Shengwen
AU  - Wu S
AD  - Department of Toxicology, School of Public Health, China Medical University, 
      No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning Province, 
      People's Republic of China.
FAU - Lu, Xiaobo
AU  - Lu X
AD  - Department of Toxicology, School of Public Health, China Medical University, 
      No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning Province, 
      People's Republic of China. xblu@cmu.edu.cn.
LA  - eng
GR  - 81773470/the National Natural Science Foundation of China/
GR  - 20170540991/Natural Science Foundation of Liaoning Province/
PT  - Journal Article
DEP - 20181206
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - 0 (Bdnf protein, rat)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 2P299V784P (Lead)
RN  - 459AG36T1B (Dehydroepiandrosterone)
RN  - C42K0PH13C (Diethylhexyl Phthalate)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Dehydroepiandrosterone/metabolism
MH  - Diethylhexyl Phthalate/*toxicity
MH  - Hippocampus/*metabolism/pathology
MH  - Lead/*toxicity
MH  - Learning/*drug effects
MH  - Male
MH  - Memory/*drug effects
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Combined exposure
OT  - DEHP
OT  - Lead
OT  - Learning and memory
EDAT- 2018/12/14 06:00
MHDA- 2019/12/25 06:00
CRDT- 2018/12/08 06:00
PHST- 2018/08/28 00:00 [received]
PHST- 2018/11/19 00:00 [accepted]
PHST- 2018/12/14 06:00 [pubmed]
PHST- 2019/12/25 06:00 [medline]
PHST- 2018/12/08 06:00 [entrez]
AID - 10.1007/s12011-018-1586-5 [pii]
AID - 10.1007/s12011-018-1586-5 [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2019 Sep;191(1):126-134. doi: 10.1007/s12011-018-1586-5. 
      Epub 2018 Dec 6.