PMID- 30524197
OWN - NLM
STAT- MEDLINE
DCOM- 20190219
LR  - 20221207
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2018
DP  - 2018
TI  - Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex 
      Hormone Profiles in Females with Metabolic-Related Diseases.
PG  - 7375294
LID - 10.1155/2018/7375294 [doi]
LID - 7375294
AB  - Asprosin is a white adipose tissue-derived hormone that increases abnormally in 
      mammals with insulin resistance. However, the role of asprosin in polycystic 
      ovary syndrome (PCOS), a disease partly characterized by insulin resistance, and 
      its potential connection with type 2 diabetes mellitus (T2DM) and PCOS has not 
      been thoroughly elucidated to date. To investigate the association of asprosin 
      with metabolic profiles, sex-related hormones, or inflammation in females with 
      T2DM or PCOS, plasma asprosin and metabolic indicators were measured in 66 
      healthy females, 53 female patients with T2DM, and 41 patients with PCOS. 
      Spearman's correlation analysis and binary logistic regression analysis models 
      were used. Plasma asprosin was significantly higher in T2DM females than in 
      healthy subjects (P < 0.001) and was positively correlated with fasting blood 
      glucose (FBG), hemoglobin A1c (HbA1c), and HOMA-IR (P < 0.05). Asprosin in PCOS 
      subjects was also higher than in healthy subjects (P < 0.001) but lower than in 
      T2DM subjects (P < 0.05), and it was positively correlated with FBG, HbA1c, 
      HOMA-IR, LDL-c, APOB, APOE, and testosterone (P < 0.05). The BMI-categorized 
      subgroups of PCOS subjects also showed correlations of asprosin with metabolic 
      profiles and sex-related hormones. Binary logistic regression analysis revealed 
      that plasma asprosin level acted as an independent risk factor for T2DM or PCOS. 
      These findings suggest the correlation of plasma asprosin level with glucose 
      metabolism, lipid metabolism, sex-related hormones, and inflammation in females, 
      supporting asprosin as a potential predictive factor for females with 
      metabolic-related diseases. This trial is registered with ChiCTR-ROC-17010719.
FAU - Li, Xing
AU  - Li X
AD  - Department of Endocrinology, Xinqiao Hospital, Third Military Medical University 
      (Army Medical University), Chongqing 400037, China.
FAU - Liao, Mingyu
AU  - Liao M
AD  - Department of Endocrinology, Xinqiao Hospital, Third Military Medical University 
      (Army Medical University), Chongqing 400037, China.
FAU - Shen, Rufei
AU  - Shen R
AD  - Department of Endocrinology, Xinqiao Hospital, Third Military Medical University 
      (Army Medical University), Chongqing 400037, China.
FAU - Zhang, Linlin
AU  - Zhang L
AD  - Department of Endocrinology, Xinqiao Hospital, Third Military Medical University 
      (Army Medical University), Chongqing 400037, China.
FAU - Hu, Hua
AU  - Hu H
AD  - Department of Obstetrics and Gynecology, Xinqiao Hospital, Third Military Medical 
      University (Army Medical University), Chongqing 400037, China.
FAU - Wu, Jun
AU  - Wu J
AD  - Department of Health Management, Xinqiao Hospital, Third Military Medical 
      University (Army Medical University), Chongqing 400037, China.
FAU - Wang, Xiuli
AU  - Wang X
AD  - Department of Health Management, Xinqiao Hospital, Third Military Medical 
      University (Army Medical University), Chongqing 400037, China.
FAU - Qu, Hua
AU  - Qu H
AUID- ORCID: 0000-0002-4895-5979
AD  - Department of Endocrinology, Xinqiao Hospital, Third Military Medical University 
      (Army Medical University), Chongqing 400037, China.
FAU - Guo, Shaodong
AU  - Guo S
AD  - Department of Nutrition and Food Science College of Agriculture and Life 
      Sciences, Texas A&M University, Texas 77843, USA.
FAU - Long, Min
AU  - Long M
AUID- ORCID: 0000-0003-1071-8131
AD  - Department of Endocrinology, Xinqiao Hospital, Third Military Medical University 
      (Army Medical University), Chongqing 400037, China.
FAU - Zheng, Hongting
AU  - Zheng H
AUID- ORCID: 0000-0002-6930-0103
AD  - Department of Endocrinology, Xinqiao Hospital, Third Military Medical University 
      (Army Medical University), Chongqing 400037, China.
LA  - eng
PT  - Journal Article
DEP - 20181106
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Blood Glucose)
RN  - 0 (FBN1 protein, human)
RN  - 0 (Fibrillin-1)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Microfilament Proteins)
RN  - 0 (Peptide Fragments)
RN  - 0 (Peptide Hormones)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Fasting/blood
MH  - Female
MH  - Fibrillin-1
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Lipid Metabolism/physiology
MH  - Logistic Models
MH  - Microfilament Proteins/*blood
MH  - Peptide Fragments/*blood
MH  - Peptide Hormones/*blood
MH  - Polycystic Ovary Syndrome/*blood
MH  - Risk Factors
MH  - Testosterone/blood
PMC - PMC6247534
EDAT- 2018/12/14 06:00
MHDA- 2019/03/21 06:00
PMCR- 2018/11/06
CRDT- 2018/12/08 06:00
PHST- 2018/07/09 00:00 [received]
PHST- 2018/10/01 00:00 [revised]
PHST- 2018/10/16 00:00 [accepted]
PHST- 2018/12/08 06:00 [entrez]
PHST- 2018/12/14 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
PHST- 2018/11/06 00:00 [pmc-release]
AID - 10.1155/2018/7375294 [doi]
PST - epublish
SO  - Mediators Inflamm. 2018 Nov 6;2018:7375294. doi: 10.1155/2018/7375294. 
      eCollection 2018.