PMID- 30524358
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 9
DP  - 2018
TI  - Serum Levels of Brain-Derived Neurotrophic Factor and Insulin-Like Growth Factor 
      1 Are Associated With Autonomic Dysfunction and Impaired Cerebral Autoregulation 
      in Patients With Epilepsy.
PG  - 969
LID - 10.3389/fneur.2018.00969 [doi]
LID - 969
AB  - Background: Brain-derived neurotrophic factor (BDNF) and insulin-like growth 
      factor 1 (IGF-1) may regulate the autonomic nervous system (ANS) in epilepsy. The 
      present study investigated the role of IGF-1 and BDNF in the regulation of 
      autonomic functions and cerebral autoregulation in patients with epilepsy. 
      Methods: A total of 57 patients with focal epilepsy and 35 healthy controls were 
      evaluated and their sudomotor, cardiovagal, and adrenergic functions were 
      assessed using a battery of ANS function tests, including the deep breathing, 
      Valsalva maneuver, head-up tilting, and Q-sweat tests. Cerebral autoregulation 
      was measured by transcranial doppler during the breath-holding test and the 
      Valsalva maneuver. Interictal serum levels of BDNF and IGF-1 were measured with 
      enzyme-linked immunosorbent assay kits. Results: During interictal period, 
      reduced serum levels of BDNF and IGF-1, impaired autonomic functions, and 
      decreased cerebral autoregulation were noted in patients with epilepsy compared 
      with healthy controls. Reduced serum levels of BDNF correlated with age, 
      adrenergic and sudomotor function, overall autonomic dysfunction, and the 
      autoregulation index calculated in Phase II of the Valsalva maneuver, and showed 
      associations with focal to bilateral tonic-clonic seizures. Reduced serum levels 
      of IGF-1 were found to correlate with age and cardiovagal function, a parameter 
      of cerebral autoregulation (the breath-hold index). Patients with a longer 
      history of epilepsy, higher seizure frequency, and temporal lobe epilepsy had 
      lower serum levels of IGF-1. Conclusions: Long-term epilepsy and severe epilepsy, 
      particularly temporal lobe epilepsy, may perturb BDNF and IGF-1 signaling in the 
      central autonomic system, contributing to the autonomic dysfunction and impaired 
      cerebral autoregulation observed in patients with focal epilepsy.
FAU - Chen, Shu-Fang
AU  - Chen SF
AD  - Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung 
      University College of Medicine, Kaohsiung, Taiwan.
FAU - Jou, Shuo-Bin
AU  - Jou SB
AD  - Department of Neurology, Mackay Memorial Hospital and Mackay Medical College, 
      Taipei, Taiwan.
FAU - Chen, Nai-Ching
AU  - Chen NC
AD  - Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung 
      University College of Medicine, Kaohsiung, Taiwan.
FAU - Chuang, Hung-Yi
AU  - Chuang HY
AD  - Department of Occupational and Environmental Medicine, Kaohsiung Medical 
      University Hospital and School of Public Health, Kaohsiung Medical University, 
      Kaohsiung, Taiwan.
FAU - Huang, Chi-Ren
AU  - Huang CR
AD  - Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung 
      University College of Medicine, Kaohsiung, Taiwan.
FAU - Tsai, Meng-Han
AU  - Tsai MH
AD  - Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung 
      University College of Medicine, Kaohsiung, Taiwan.
FAU - Tan, Teng-Yeow
AU  - Tan TY
AD  - Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung 
      University College of Medicine, Kaohsiung, Taiwan.
FAU - Tsai, Wan-Chen
AU  - Tsai WC
AD  - Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung 
      University College of Medicine, Kaohsiung, Taiwan.
FAU - Chang, Chiung-Chih
AU  - Chang CC
AD  - Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung 
      University College of Medicine, Kaohsiung, Taiwan.
FAU - Chuang, Yao-Chung
AU  - Chuang YC
AD  - Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung 
      University College of Medicine, Kaohsiung, Taiwan.
AD  - Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung 
      Memorial Hospital, Kaohsiung, Taiwan.
AD  - Department of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung 
      Medical University, Kaohsiung, Taiwan.
AD  - Department of Biological Science, National Sun Yat-sen University, Kaohsiung, 
      Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20181120
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC6256185
OTO - NOTNLM
OT  - autonomic nervous system dysfunction
OT  - brain-derived neurotrophic factor
OT  - cerebral autoregulation
OT  - epilepsy
OT  - insulin-like growth factor 1
EDAT- 2018/12/14 06:00
MHDA- 2018/12/14 06:01
PMCR- 2018/11/20
CRDT- 2018/12/08 06:00
PHST- 2018/08/03 00:00 [received]
PHST- 2018/10/29 00:00 [accepted]
PHST- 2018/12/08 06:00 [entrez]
PHST- 2018/12/14 06:00 [pubmed]
PHST- 2018/12/14 06:01 [medline]
PHST- 2018/11/20 00:00 [pmc-release]
AID - 10.3389/fneur.2018.00969 [doi]
PST - epublish
SO  - Front Neurol. 2018 Nov 20;9:969. doi: 10.3389/fneur.2018.00969. eCollection 2018.