PMID- 30524680
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 2008-3866 (Print)
IS  - 2008-3874 (Electronic)
IS  - 2008-3866 (Linking)
VI  - 21
IP  - 10
DP  - 2018 Oct
TI  - Neuroprotective effects of gallic acid in a rat model of traumatic brain injury: 
      behavioral, electrophysiological, and molecular studies.
PG  - 1056-1063
LID - 10.22038/IJBMS.2018.29639.7165 [doi]
AB  - OBJECTIVES: Traumatic brain injury (TBI) is one of the main causes of 
      intellectual and cognitive disabilities. Clinically, it is essential to limit the 
      development of cognitive impairment after TBI. In the present study, the 
      neuroprotective effects of gallic acid (GA) on neurological score, memory, 
      long-term potentiation (LTP) from hippocampal dentate gyrus (hDG), brain lipid 
      peroxidation and cytokines after TBI were evaluated. MATERIALS AND METHODS: 
      Seventy-two adult male Wistar rats divided randomly into three groups with 24 in 
      each: Veh + Sham, Veh + TBI and GA + TBI (GA; 100 mg/kg, PO for 7 days before TBI 
      induction). Brain injury was made by Marmarou's method. Briefly, a 200 g weight 
      was fallen down from a 2 m height through a free-falling tube onto the head of 
      anesthetized animal. RESULTS: Veterinary coma scores (VCS), memory and recorded 
      hDG -LTP significantly reduced in Veh + TBI group at 1 and 24 hr after TBI when 
      compared to Veh + Sham (P<0.001), respectively, while brain tissue content of 
      interleukin-1beta (IL-1beta), IL-6, tumor necrosis factor-alpha (TNF-alpha) and malondialdehyde 
      (MDA) were increased significantly (P<0.001). Pretreatment of TBI rats with GA 
      improved clinical signs, memory and hDG-LTP significantly (P<0.001) compared to 
      Veh + TBI group, while brain tissue content of IL-1beta, IL-6, TNF-alpha and MDA were 
      decreased significantly (P<0.001). CONCLUSION: Our results propose that GA has 
      neuroprotective effect on memory and LTP impairment due to TBI through decrement 
      of brain lipid peroxidation and cerebral pro-inflammatory cytokines.
FAU - Mirshekar, Mohammad Ali
AU  - Mirshekar MA
AD  - Department of Physiology, School of Medicine, Ahvaz Jundishapur University of 
      Medical Sciences, Ahvaz, Iran.
AD  - Department of Physiology, School of Medicine and Clinical Immunology Research 
      Center, Zahedan University of Medical Sciences, Zahedan, Iran.
FAU - Sarkaki, Alireza
AU  - Sarkaki A
AD  - Department of Physiology, School of Medicine, Ahvaz Jundishapur University of 
      Medical Sciences, Ahvaz, Iran.
AD  - Ahvaz Physiology Research Center, Ahvaz Jundishapur University of Medical 
      Sciences, Ahvaz, Iran.
FAU - Farbood, Yaghoub
AU  - Farbood Y
AD  - Department of Physiology, School of Medicine, Ahvaz Jundishapur University of 
      Medical Sciences, Ahvaz, Iran.
AD  - Ahvaz Physiology Research Center, Ahvaz Jundishapur University of Medical 
      Sciences, Ahvaz, Iran.
FAU - Gharib Naseri, Mohammad Kazem
AU  - Gharib Naseri MK
AD  - Ahvaz Physiology Research Center, Ahvaz Jundishapur University of Medical 
      Sciences, Ahvaz, Iran.
FAU - Badavi, Mohammad
AU  - Badavi M
AD  - Department of Physiology, School of Medicine, Ahvaz Jundishapur University of 
      Medical Sciences, Ahvaz, Iran.
AD  - Ahvaz Physiology Research Center, Ahvaz Jundishapur University of Medical 
      Sciences, Ahvaz, Iran.
FAU - Mansouri, Mohammad Taghi
AU  - Mansouri MT
AD  - Ahvaz Physiology Research Center, Ahvaz Jundishapur University of Medical 
      Sciences, Ahvaz, Iran.
AD  - Department of Pharmacology, School of Medicine, Ahvaz Jundishapur University of 
      Medical Sciences, Ahvaz, Iran.
FAU - Haghparast, Abbas
AU  - Haghparast A
AD  - Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Basic Med Sci
JT  - Iranian journal of basic medical sciences
JID - 101517966
PMC - PMC6281072
OTO - NOTNLM
OT  - Brain inflammation
OT  - Gallic acid
OT  - Long-term potentiation Memory
OT  - Rat
OT  - Traumatic brain injury
EDAT- 2018/12/14 06:00
MHDA- 2018/12/14 06:01
PMCR- 2018/10/01
CRDT- 2018/12/08 06:00
PHST- 2018/12/08 06:00 [entrez]
PHST- 2018/12/14 06:00 [pubmed]
PHST- 2018/12/14 06:01 [medline]
PHST- 2018/10/01 00:00 [pmc-release]
AID - 10.22038/IJBMS.2018.29639.7165 [doi]
PST - ppublish
SO  - Iran J Basic Med Sci. 2018 Oct;21(10):1056-1063. doi: 
      10.22038/IJBMS.2018.29639.7165.