PMID- 30524707
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2048-6790 (Print)
IS  - 2048-6790 (Electronic)
IS  - 2048-6790 (Linking)
VI  - 7
DP  - 2018
TI  - Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy 
      subjects: a double-blind cross-over trial.
PG  - e33
LID - 10.1017/jns.2018.23 [doi]
LID - e33
AB  - The increased prevalence of lifestyle diseases, such as the metabolic syndrome 
      and type 2 diabetes mellitus (T2DM), calls for more knowledge on dietary 
      treatments targeting the specific metabolic pathways involved in these 
      conditions. Several studies have shown a protein preload before a meal to be 
      effective in lowering the postprandial glycaemic response in healthy individuals 
      and patients with T2DM. The aim of the present study was to assess the effect of 
      a marine protein hydrolysate (MPH) from Atlantic cod (Gadus morhua) on 
      postprandial glucose metabolism in healthy, middle-aged to elderly subjects. This 
      double-blind cross-over trial (n 41) included two study days with 4-7 d wash-out 
      in between. The intervention consisted of 20 mg of MPH (or casein as control) per 
      kg body weight given before a breakfast meal. The primary outcome was 
      postprandial response in glucose metabolism, measured by samples of serum 
      glucose, insulin and plasma glucagon-like peptide 1 (GLP-1) in 20 min intervals 
      for 180 min. In a mixed-model regression analysis, no differences were observed 
      between MPH and control for postprandial glucose concentration (mean difference: 
      -0.04 (95 % CI -0.17, 0.09) mmol/l; P = 0.573) or GLP-1 concentration (mean 
      difference between geometric means: 1.02 (95 % CI 0.99, 1.06) pmol/l; P = 0.250). 
      The postprandial insulin concentration was significantly lower after MPH compared 
      with control (mean difference between geometric means: 1.067 (95 % CI 1.01, 1.13) 
      mIU/l; P = 0.032). Our findings demonstrate that a single dose of MPH before a 
      breakfast meal reduces postprandial insulin secretion, without affecting blood 
      glucose response or GLP-1 levels, in healthy individuals. Further studies with 
      repeated dosing and in target groups with abnormal glucose control are warranted.
FAU - Dale, Hanna Fjeldheim
AU  - Dale HF
AUID- ORCID: 0000-0002-0710-6057
AD  - Department of Clinical Medicine, Centre for Nutrition, University of Bergen, 
      Bergen, Norway.
AD  - Division of Gastroenterology, Department of Medicine, Haukeland University 
      Hospital, Bergen, Norway.
FAU - Jensen, Caroline
AU  - Jensen C
AD  - Department of Clinical Medicine, Centre for Nutrition, University of Bergen, 
      Bergen, Norway.
FAU - Hausken, Trygve
AU  - Hausken T
AD  - Department of Clinical Medicine, Centre for Nutrition, University of Bergen, 
      Bergen, Norway.
AD  - Division of Gastroenterology, Department of Medicine, Haukeland University 
      Hospital, Bergen, Norway.
AD  - National Centre of Functional Gastrointestinal Disorders, Haukeland University 
      Hospital, Bergen, Norway.
FAU - Lied, Einar
AU  - Lied E
AD  - Firmenich Bjorge Biomarin AS, Ellingsoy, Alesund, Norway.
FAU - Hatlebakk, Jan Gunnar
AU  - Hatlebakk JG
AD  - Department of Clinical Medicine, Centre for Nutrition, University of Bergen, 
      Bergen, Norway.
AD  - Division of Gastroenterology, Department of Medicine, Haukeland University 
      Hospital, Bergen, Norway.
AD  - National Centre of Functional Gastrointestinal Disorders, Haukeland University 
      Hospital, Bergen, Norway.
FAU - Bronstad, Ingeborg
AU  - Bronstad I
AD  - Department of Clinical Medicine, University of Bergen, Bergen, Norway.
AD  - National Centre for Ultrasound in Gastroenterology, Haukeland University 
      Hospital, Bergen, Norway.
FAU - Lihaug Hoff, Dag Arne
AU  - Lihaug Hoff DA
AD  - Division of Gastroenterology, Department of Medicine, Alesund Hospital, More & 
      Romsdal Hospital Trust, Alesund, Norway.
AD  - Department of Clinical and Molecular Medicine, Faculty of Medicine and Health 
      Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
FAU - Lied, Gulen Arslan
AU  - Lied GA
AD  - Department of Clinical Medicine, Centre for Nutrition, University of Bergen, 
      Bergen, Norway.
AD  - Division of Gastroenterology, Department of Medicine, Haukeland University 
      Hospital, Bergen, Norway.
AD  - National Centre of Functional Gastrointestinal Disorders, Haukeland University 
      Hospital, Bergen, Norway.
LA  - eng
PT  - Journal Article
DEP - 20181128
PL  - England
TA  - J Nutr Sci
JT  - Journal of nutritional science
JID - 101590587
EIN - J Nutr Sci. 2019 Jan 18;8:e1. PMID: 30719283
PMC - PMC6277920
OTO - NOTNLM
OT  - BCAA, branched-chain amino acids
OT  - Fish protein
OT  - GLP-1, glucagon-like peptide 1
OT  - Glucose metabolism
OT  - MPH, marine protein hydrolysate
OT  - Marine peptides
OT  - Marine protein hydrolysate
OT  - T2DM, type 2 diabetes mellitus
EDAT- 2018/12/14 06:00
MHDA- 2018/12/14 06:01
PMCR- 2018/01/01
CRDT- 2018/12/08 06:00
PHST- 2018/10/29 00:00 [received]
PHST- 2018/11/01 00:00 [accepted]
PHST- 2018/12/08 06:00 [entrez]
PHST- 2018/12/14 06:00 [pubmed]
PHST- 2018/12/14 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 00023 [pii]
AID - 10.1017/jns.2018.23 [doi]
PST - epublish
SO  - J Nutr Sci. 2018 Nov 28;7:e33. doi: 10.1017/jns.2018.23. eCollection 2018.