PMID- 30524928
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231004
IS  - 2196-3002 (Print)
IS  - 2196-3002 (Electronic)
VI  - 5
IP  - 4
DP  - 2018
TI  - Oral Polymorphonuclear Neutrophil Contributes to Oral Health.
PG  - 211-220
LID - 10.1007/s40496-018-0199-6 [doi]
AB  - PURPOSE OF REVIEW: Oral health is maintained in a dynamic equilibrium between the 
      host immunity and the oral microbiome. Oral polymorphonuclear neutrophils (oPMNs) 
      are important innate immune cells in the oral cavity. RECENT FINDINGS: The oPMNs 
      play a co-controlling part in the maintenance of oral equilibrium. In human 
      saliva, the oPMNs integrity is preserved, and their function remains unaffected. 
      In general, oPMNs are in a higher state of baseline activation compared to 
      peripheral PMNs. However, in periodontitis, the oPMNs' activation state can 
      result in excessive release of damaging molecules in the extracellular 
      environment. SUMMARY: The presence of oPMNs may unwittingly negatively impact the 
      integrity of the oral tissues. While most of the oPMN functions occur 
      intracellularly, release of their potent active mediators into the extracellular 
      environment may jeopardize oral homeostasis and its integrity. The dual nature of 
      oPMNs, both beneficial and detrimental, remains a challenging and understudied 
      topic.
FAU - Rijkschroeff, Patrick
AU  - Rijkschroeff P
AD  - 1Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), 
      University of Amsterdam and VU University Amsterdam, Gustav Mahlerlaan 3004, 1081 
      LA Amsterdam, The Netherlands. ISNI: 0000000084992262. GRID: grid.7177.6
FAU - Loos, Bruno G
AU  - Loos BG
AD  - 1Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), 
      University of Amsterdam and VU University Amsterdam, Gustav Mahlerlaan 3004, 1081 
      LA Amsterdam, The Netherlands. ISNI: 0000000084992262. GRID: grid.7177.6
FAU - Nicu, Elena A
AU  - Nicu EA
AD  - 1Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), 
      University of Amsterdam and VU University Amsterdam, Gustav Mahlerlaan 3004, 1081 
      LA Amsterdam, The Netherlands. ISNI: 0000000084992262. GRID: grid.7177.6
AD  - Opris Dent SRL, Sibiu, Romania.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20181025
PL  - Switzerland
TA  - Curr Oral Health Rep
JT  - Current oral health reports
JID - 101626542
PMC - PMC6244624
OTO - NOTNLM
OT  - Apoptosis
OT  - Degranulation
OT  - Neutrophils
OT  - Oral health
OT  - Reactive oxygen species
COIS- All authors declare that they have no conflict of interest.This article does not 
      contain any studies with human or animal subjects performed by any of the 
      authors.
EDAT- 2018/12/14 06:00
MHDA- 2018/12/14 06:01
PMCR- 2018/10/25
CRDT- 2018/12/08 06:00
PHST- 2018/12/08 06:00 [entrez]
PHST- 2018/12/14 06:00 [pubmed]
PHST- 2018/12/14 06:01 [medline]
PHST- 2018/10/25 00:00 [pmc-release]
AID - 199 [pii]
AID - 10.1007/s40496-018-0199-6 [doi]
PST - ppublish
SO  - Curr Oral Health Rep. 2018;5(4):211-220. doi: 10.1007/s40496-018-0199-6. Epub 
      2018 Oct 25.