PMID- 30527359
OWN - NLM
STAT- MEDLINE
DCOM- 20190322
LR  - 20190322
IS  - 1618-0631 (Electronic)
IS  - 0344-0338 (Linking)
VI  - 215
IP  - 2
DP  - 2019 Feb
TI  - Spondin-2 is a novel diagnostic biomarker for laryngeal squamous cell carcinoma.
PG  - 286-291
LID - S0344-0338(18)30927-0 [pii]
LID - 10.1016/j.prp.2018.11.017 [doi]
AB  - Spondin-2, belongs to the SOX (SRY-related HMG box) gene family, plays a vital 
      role in the development of malignancy, however, the role of Spondin-2 in 
      laryngeal squamous cell carcinoma (LSCC) remains unknown. The aim of this study 
      is to investigate the prognostic significance of and probable mechanism of 
      Spondin-2 in LSCC. qRT-PCR, western blotting assays and IHC analysis demonstrated 
      that Spondin-2 was significantly increased in LSCC tissues compared with adjacent 
      non-tumorous tissues. In addition, high levels of Spondin-2 was associated with 
      clinical stage, lymph node metastasis and pathology grade of LSCC patients (P 
      ＜0.05). Kaplan-Meier analysis showed that patients with high expression of 
      Spondin-2 had a lower overall survival rate (P＜0.05) than that with low 
      expression of Spondin-2. Moreover, spondin-2 silencing inhibited the 
      proliferation of LSCC cells through inhibiting the activation of PI3K/AKT 
      signaling. In conclusion, spondin-2 might be a novel therapeutic target and 
      prognostic biomarker for LSCC patients.
CI  - Copyright (c) 2018. Published by Elsevier GmbH.
FAU - Ni, Haosheng
AU  - Ni H
AD  - Department of Otorhinolaryngology, Affiliated Hospital of Nantong University, No. 
      20 Xi Si Road, Nantong, 226001, China.
FAU - Ni, Tingting
AU  - Ni T
AD  - Department of Oncology, Nantong Tumor Hospital, No. 30 Tong Yang North Road, 
      Nantong 226001, China.
FAU - Feng, Jia
AU  - Feng J
AD  - Department of Pathology, Affiliated Hospital of Nantong University, No. 20 Xi Si 
      Road, Nantong, 226001, China.
FAU - Bian, Tingting
AU  - Bian T
AD  - Department of Pathology, Affiliated Hospital of Nantong University, No. 20 Xi Si 
      Road, Nantong, 226001, China.
FAU - Liu, Yifei
AU  - Liu Y
AD  - Department of Pathology, Affiliated Hospital of Nantong University, No. 20 Xi Si 
      Road, Nantong, 226001, China. Electronic address: ntdxliuyifei@sina.com.
FAU - Zhang, Jianguo
AU  - Zhang J
AD  - Department of Pathology, Affiliated Hospital of Nantong University, No. 20 Xi Si 
      Road, Nantong, 226001, China. Electronic address: 13815212431@163.com.
LA  - eng
PT  - Journal Article
DEP - 20181129
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (SPON2 protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/*analysis
MH  - Extracellular Matrix Proteins/*analysis
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Laryngeal Neoplasms/*diagnosis/mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/*analysis
MH  - Prognosis
MH  - Squamous Cell Carcinoma of Head and Neck/*diagnosis/mortality/pathology
OTO - NOTNLM
OT  - 5-year survival ratio
OT  - Clinicopathological characteristics
OT  - LSCC
OT  - PI3K/AKT signaling pathway
OT  - Prognostic biomarker
OT  - Spondin-2
EDAT- 2018/12/12 06:00
MHDA- 2019/03/23 06:00
CRDT- 2018/12/12 06:00
PHST- 2018/07/25 00:00 [received]
PHST- 2018/11/08 00:00 [revised]
PHST- 2018/11/23 00:00 [accepted]
PHST- 2018/12/12 06:00 [pubmed]
PHST- 2019/03/23 06:00 [medline]
PHST- 2018/12/12 06:00 [entrez]
AID - S0344-0338(18)30927-0 [pii]
AID - 10.1016/j.prp.2018.11.017 [doi]
PST - ppublish
SO  - Pathol Res Pract. 2019 Feb;215(2):286-291. doi: 10.1016/j.prp.2018.11.017. Epub 
      2018 Nov 29.