PMID- 30528492
OWN - NLM
STAT- MEDLINE
DCOM- 20200106
LR  - 20221207
IS  - 2530-0180 (Electronic)
IS  - 2530-0180 (Linking)
VI  - 66
IP  - 2
DP  - 2019 Feb
TI  - Haptoglobin levels are influenced by Hp1-Hp2 polymorphism, obesity, inflammation, 
      and hypertension in type 2 diabetes mellitus.
PG  - 99-107
LID - S2530-0164(18)30192-7 [pii]
LID - 10.1016/j.endinu.2018.07.008 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is an inflammatory condition 
      associated to obesity and increased oxidative stress. Haptoglobin (Hp) is an 
      acute phase reactant that scavenges extracorpuscular hemoglobin from circulation 
      and prevents heme-iron oxidative damage. OBJECTIVE: To assess the association 
      between Hp levels and Hp1-Hp2 gene polymorphism and clinical and laboratory 
      parameters in patients with T2DM. METHODS: The study sample consisted of 102 T2DM 
      patients and 62 controls. Hp plasma levels were measured using an ELISA assay, 
      and Hp genotyping was performed using a specific two-step allelic polymerase 
      chain reaction. RESULTS: Hp levels were higher in T2DM patients as compared to 
      controls (p=0.005). T2DM patients with high blood pressure had higher Hp levels 
      than patients without this comorbidity (p=0.021). Obese T2DM patients had higher 
      Hp levels as compared to obese controls (p=0.009) and to non-obese T2DM patients 
      (p=0.003). The Hp1-Hp1 genotype was showed to be associated to T2DM according to 
      additive (OR=3.038, 95% CI 1.127-8.192; p=0.036) and dominant model (OR=0.320, 
      95% CI 0.118-0.839; p=0.010), but Hp2 allele carriers contributed with higher Hp 
      levels in T2DM as compared to controls. Waist circumference (p=0.002), BMI 
      (p=0.001), and IL-6 (p=0.012), and hs-CRP (p=0.001) levels positively correlated 
      with Hp levels in the T2DM group. CONCLUSION: These results suggest that Hp 
      levels are influenced by Hp1-Hp2 polymorphism, obesity, inflammatory status, and 
      high blood pressure in T2DM.
CI  - Copyright (c) 2018 SEEN y SED. Publicado por Elsevier Espana, S.L.U. All rights 
      reserved.
FAU - Rodrigues, Kathryna Fontana
AU  - Rodrigues KF
AD  - Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo 
      Horizonte, Minas Gerais, Brazil.
FAU - Pietrani, Nathalia Teixeira
AU  - Pietrani NT
AD  - Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo 
      Horizonte, Minas Gerais, Brazil.
FAU - Carvalho, Laura Machado Lara
AU  - Carvalho LML
AD  - Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo 
      Horizonte, Minas Gerais, Brazil.
FAU - Bosco, Adriana Aparecida
AU  - Bosco AA
AD  - Instituto de Ensino e Pesquisa, Santa Casa de Belo Horizonte, Belo Horizonte, 
      Minas Gerais, Brazil.
FAU - Sandrim, Valeria Cristina
AU  - Sandrim VC
AD  - Instituto de Biociencias, Universidade Estadual Paulista Julio de Mesquita Filho, 
      Botucatu, Sao Paulo, Brazil.
FAU - Ferreira, Claudia Natalia
AU  - Ferreira CN
AD  - Colegio Tecnico, Universidade Federal de Minas Gerais, Belo Horizonte, Minas 
      Gerais, Brazil.
FAU - Gomes, Karina Braga
AU  - Gomes KB
AD  - Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo 
      Horizonte, Minas Gerais, Brazil; Faculdade de Farmacia, Universidade Federal de 
      Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address: 
      karinabgb@gmail.com.
LA  - eng
LA  - spa
PT  - Journal Article
DEP - 20181024
PL  - Spain
TA  - Endocrinol Diabetes Nutr (Engl Ed)
JT  - Endocrinologia, diabetes y nutricion
JID - 101717565
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Cytokines)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (HP protein, human)
RN  - 0 (Haptoglobins)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Biomarkers
MH  - Blood Glucose/analysis
MH  - C-Reactive Protein/analysis
MH  - Case-Control Studies
MH  - Comorbidity
MH  - Cross-Sectional Studies
MH  - Cytokines/blood
MH  - Diabetes Mellitus, Type 2/*blood/epidemiology
MH  - Female
MH  - Genotype
MH  - Glycated Hemoglobin/analysis
MH  - Haptoglobins/analysis/*genetics
MH  - Humans
MH  - Hypertension/*blood/epidemiology
MH  - Inflammation/*blood/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Obesity/*blood/epidemiology
MH  - Polymorphism, Genetic
MH  - Waist Circumference
MH  - Waist-Hip Ratio
OTO - NOTNLM
OT  - Diabetes mellitus tipo 2
OT  - Haptoglobin
OT  - Haptoglobina
OT  - Inflamacion
OT  - Inflammation
OT  - Obesidad
OT  - Obesity
OT  - Polimorfismos
OT  - Polymorphisms
OT  - Type 2 diabetes mellitus
EDAT- 2018/12/12 06:00
MHDA- 2020/01/07 06:00
CRDT- 2018/12/12 06:00
PHST- 2018/03/07 00:00 [received]
PHST- 2018/07/13 00:00 [revised]
PHST- 2018/07/23 00:00 [accepted]
PHST- 2018/12/12 06:00 [pubmed]
PHST- 2020/01/07 06:00 [medline]
PHST- 2018/12/12 06:00 [entrez]
AID - S2530-0164(18)30192-7 [pii]
AID - 10.1016/j.endinu.2018.07.008 [doi]
PST - ppublish
SO  - Endocrinol Diabetes Nutr (Engl Ed). 2019 Feb;66(2):99-107. doi: 
      10.1016/j.endinu.2018.07.008. Epub 2018 Oct 24.