PMID- 30528926
OWN - NLM
STAT- MEDLINE
DCOM- 20200914
LR  - 20201101
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 213
DP  - 2019 Nov
TI  - Bullying victimization in typically developing and clinical high risk (CHR) 
      adolescents: A multimodal imaging study.
PG  - 40-47
LID - S0920-9964(18)30668-6 [pii]
LID - 10.1016/j.schres.2018.11.017 [doi]
AB  - BACKGROUND: Bullying has been shown to increase the risk of developing a 
      psychotic disorder. To date, no studies have examined brain behavior 
      relationships within the context of bullying victimization in clinical high-risk 
      (CHR) youth, a group characterized by both gray and white matter abnormalities. 
      The present study employed multimodal neuroimaging to examine possible neural 
      mechanisms associated with bullying victimization. METHODS: CHR and healthy 
      volunteers underwent clinical interviews, parent reports and MRI scans. Regions 
      of interest (ROIs) were picked based on sensitivity to environmental stress, 
      including hippocampal, amygdala, and orbitofrontal cortex (OFC) structural ROIs, 
      and uncinate fasciculus white matter integrity. RESULTS: CHR individuals were 
      more exposed to bullying victimization than healthy volunteers, and bullying was 
      associated with depressive symptoms across the whole sample. CHR individuals 
      exhibited smaller volumes in OFC, but not in other ROIs. Increased bullying 
      exposure was associated with lower medial OFC volumes in CHR and HV groups 
      independently. Results ought to be interpreted as preliminary, as they did not 
      survive correction at the whole brain level. DISCUSSION: Bullying victimization 
      may affect or be affected by volumetric OFC differences in both healthy and CHR 
      individuals. However, given CHR showed greater exposure to bullying as well as 
      underlying vulnerability (e.g. lower volumes), results also point to etiological 
      clues and novel intervention targets, though future replication is needed in 
      better powered samples.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Vargas, Teresa
AU  - Vargas T
AD  - Northwestern University, Department of Psychology, USA. Electronic address: 
      teresavargas@u.northwestern.edu.
FAU - Damme, Katherine S F
AU  - Damme KSF
AD  - Northwestern University, Department of Psychology, USA.
FAU - Mittal, Vijay A
AU  - Mittal VA
AD  - Northwestern University, Department of Psychology, USA; Northwestern University, 
      Department of Psychiatry, USA; Northwestern University, Department of Medical 
      Social Sciences, USA; Northwestern University, Institute for Policy Research, 
      USA; Northwestern University, Institute for Innovations in Developmental 
      Sciences, USA.
LA  - eng
GR  - R01 MH112545/MH/NIMH NIH HHS/United States
GR  - R21 MH110374/MH/NIMH NIH HHS/United States
GR  - R33 MH103231/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20181207
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Bullying
MH  - *Crime Victims
MH  - Depression/*physiopathology
MH  - Diffusion Tensor Imaging
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Gray Matter/diagnostic imaging/*pathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Multimodal Imaging
MH  - Prefrontal Cortex/diagnostic imaging/*pathology
MH  - *Psychotic Disorders
MH  - Risk
MH  - White Matter/diagnostic imaging/*pathology
MH  - Young Adult
PMC - PMC6555683
MID - NIHMS1516254
OTO - NOTNLM
OT  - Bullying
OT  - Clinical high risk
OT  - DTI
OT  - MRI
OT  - Orbital frontal cortex
COIS- Conflict of interest The authors report no biomedical financial interests or 
      conflicts of interest. V.A.M is a consultant with Takeda Pharmaceuticals.
EDAT- 2018/12/12 06:00
MHDA- 2020/09/15 06:00
PMCR- 2020/11/01
CRDT- 2018/12/12 06:00
PHST- 2018/07/31 00:00 [received]
PHST- 2018/11/12 00:00 [revised]
PHST- 2018/11/15 00:00 [accepted]
PHST- 2018/12/12 06:00 [pubmed]
PHST- 2020/09/15 06:00 [medline]
PHST- 2018/12/12 06:00 [entrez]
PHST- 2020/11/01 00:00 [pmc-release]
AID - S0920-9964(18)30668-6 [pii]
AID - 10.1016/j.schres.2018.11.017 [doi]
PST - ppublish
SO  - Schizophr Res. 2019 Nov;213:40-47. doi: 10.1016/j.schres.2018.11.017. Epub 2018 
      Dec 7.