PMID- 30528936
OWN - NLM
STAT- MEDLINE
DCOM- 20200225
LR  - 20200225
IS  - 1873-5177 (Electronic)
IS  - 0091-3057 (Linking)
VI  - 176
DP  - 2019 Jan
TI  - Role of Actinobacteria and Coriobacteriia in the antidepressant effects of 
      ketamine in an inflammation model of depression.
PG  - 93-100
LID - S0091-3057(18)30605-1 [pii]
LID - 10.1016/j.pbb.2018.12.001 [doi]
AB  - Ketamine, an N-methyl-d-aspartic acid receptor (NMDAR) antagonist, elicits 
      rapid-acting and sustained antidepressant effects in treatment-resistant 
      depressed patients. Accumulating evidence suggests that gut microbiota via the 
      gut-brain axis play a role in the pathogenesis of depression, thereby 
      contributing to the antidepressant actions of certain compounds. Here we 
      investigated the role of gut microbiota in the antidepressant effects of ketamine 
      in lipopolysaccharide (LPS)-induced inflammation model of depression. Ketamine 
      (10 mg/kg) significantly attenuated the increased immobility time in forced 
      swimming test (FST), which was associated with the improvements in alpha-diversity, 
      consisting of Shannon, Simpson and Chao 1 indices. In addition to alpha-diversity, 
      beta-diversity, such as principal coordinates analysis (PCoA), and linear 
      discriminant analysis (LDA) coupled with effect size measurements (LEfSe), showed 
      a differential profile after ketamine treatment. Furthermore, a total of 30 
      bacteria were significantly altered in the LPS + saline treated mice and 
      LPS + ketamine treated mice. Interestingly, two bacteria, including the phylum 
      Actinobacteria and the class Coriobacteriia were significantly correlated with 
      the immobility time of FST. Importantly, the receiver operating characteristic 
      (ROC) curves demonstrated that the phylum Actinobacteria and the class 
      Coriobacteriia were potential biomarker for the antidepressant effects of 
      ketamine in an inflammation model. These findings suggest that antidepressant 
      effects of ketamine might be related to the regulation of abnormal composition of 
      gut microbiota, and that the phylum Actinobacteria and the class Coriobacteriia 
      might be potential biomarkers for ketamine's antidepressant efficacy.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Huang, Niannian
AU  - Huang N
AD  - Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430030, China.
FAU - Hua, Dongyu
AU  - Hua D
AD  - Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430030, China.
FAU - Zhan, Gaofeng
AU  - Zhan G
AD  - Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430030, China.
FAU - Li, Shan
AU  - Li S
AD  - Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430030, China.
FAU - Zhu, Bin
AU  - Zhu B
AD  - Department of Internal Medicine, The Third Affiliated Hospital of Soochow 
      University, Changzhou 213003, China.
FAU - Jiang, Riyue
AU  - Jiang R
AD  - Department of Internal Medicine, The Third Affiliated Hospital of Soochow 
      University, Changzhou 213003, China.
FAU - Yang, Ling
AU  - Yang L
AD  - Department of Internal Medicine, The Third Affiliated Hospital of Soochow 
      University, Changzhou 213003, China.
FAU - Bi, Jiangjiang
AU  - Bi J
AD  - Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430030, China.
FAU - Xu, Hui
AU  - Xu H
AD  - Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430030, China.
FAU - Hashimoto, Kenji
AU  - Hashimoto K
AD  - Division of Clinical Neuroscience, Chiba University Center for Forensic Mental 
      Health, Chiba 260-8670, Japan.
FAU - Luo, Ailin
AU  - Luo A
AD  - Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430030, China. Electronic address: 
      alluo@tjh.tjmu.edu.cn.
FAU - Yang, Chun
AU  - Yang C
AD  - Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430030, China. Electronic address: 
      chunyang@tjh.tjmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181205
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Antidepressive Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 690G0D6V8H (Ketamine)
SB  - IM
MH  - Actinobacteria/drug effects/*physiology
MH  - Animals
MH  - Antidepressive Agents/administration & dosage/*pharmacology
MH  - Behavior, Animal/drug effects
MH  - Biomarkers
MH  - Depression/chemically induced/*drug therapy/*microbiology
MH  - Depressive Disorder/chemically induced/*drug therapy/*microbiology
MH  - Disease Models, Animal
MH  - Gastrointestinal Microbiome/drug effects
MH  - Inflammation/chemically induced/drug therapy
MH  - Ketamine/administration & dosage/*pharmacology
MH  - Lipopolysaccharides/pharmacology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - ROC Curve
MH  - Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors
OTO - NOTNLM
OT  - Depression
OT  - Gut microbiota
OT  - Ketamine
OT  - Lipopolysaccharide
EDAT- 2018/12/12 06:00
MHDA- 2020/02/26 06:00
CRDT- 2018/12/12 06:00
PHST- 2018/11/22 00:00 [received]
PHST- 2018/12/04 00:00 [revised]
PHST- 2018/12/04 00:00 [accepted]
PHST- 2018/12/12 06:00 [pubmed]
PHST- 2020/02/26 06:00 [medline]
PHST- 2018/12/12 06:00 [entrez]
AID - S0091-3057(18)30605-1 [pii]
AID - 10.1016/j.pbb.2018.12.001 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2019 Jan;176:93-100. doi: 10.1016/j.pbb.2018.12.001. 
      Epub 2018 Dec 5.