PMID- 30529143
OWN - NLM
STAT- MEDLINE
DCOM- 20191210
LR  - 20240324
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 169
DP  - 2019 Feb
TI  - Methodological issues in a prospective study on plasma concentrations of 
      persistent organic pollutants and pancreatic cancer risk within the EPIC cohort.
PG  - 417-433
LID - S0013-9351(18)30609-1 [pii]
LID - 10.1016/j.envres.2018.11.027 [doi]
AB  - BACKGROUND: The use of biomarkers of environmental exposure to explore new risk 
      factors for pancreatic cancer presents clinical, logistic, and methodological 
      challenges that are also relevant in research on other complex diseases. 
      OBJECTIVES: First, to summarize the main design features of a prospective 
      case-control study -nested within the European Prospective Investigation into 
      Cancer and Nutrition (EPIC) cohort- on plasma concentrations of persistent 
      organic pollutants (POPs) and pancreatic cancer risk. And second, to assess the 
      main methodological challenges posed by associations among characteristics and 
      habits of study participants, fasting status, time from blood draw to cancer 
      diagnosis, disease progression bias, basis of cancer diagnosis, and plasma 
      concentrations of lipids and POPs. Results from etiologic analyses on POPs and 
      pancreatic cancer risk, and other analyses, will be reported in future articles. 
      METHODS: Study subjects were 1533 participants (513 cases and 1020 controls 
      matched by study centre, sex, age at blood collection, date and time of blood 
      collection, and fasting status) enrolled between 1992 and 2000. Plasma 
      concentrations of 22 POPs were measured by gas chromatography - triple quadrupole 
      mass spectrometry (GC-MS/MS). To estimate the magnitude of the associations we 
      calculated multivariate-adjusted odds ratios by unconditional logistic 
      regression, and adjusted geometric means by General Linear Regression Models. 
      RESULTS: There were differences among countries in subjects' characteristics (as 
      age, gender, smoking, lipid and POP concentrations), and in study characteristics 
      (as time from blood collection to index date, year of last follow-up, length of 
      follow-up, basis of cancer diagnosis, and fasting status). Adjusting for centre 
      and time of blood collection, no factors were significantly associated with 
      fasting status. Plasma concentrations of lipids were related to age, body mass 
      index, fasting, country, and smoking. We detected and quantified 16 of the 22 
      POPs in more than 90% of individuals. All 22 POPs were detected in some 
      participants, and the smallest number of POPs detected in one person was 15 
      (median, 19) with few differences by country. The highest concentrations were 
      found for p,p'-DDE, PCBs 153 and 180 (median concentration: 3371, 1023, and 810 
      pg/mL, respectively). We assessed the possible occurrence of disease progression 
      bias (DPB) in eight situations defined by lipid and POP measurements, on one 
      hand, and by four factors: interval from blood draw to index date, tumour 
      subsite, tumour stage, and grade of differentiation, on the other. In seven of 
      the eight situations results supported the absence of DPB. CONCLUSIONS: The 
      coexistence of differences across study centres in some design features and 
      participant characteristics is of relevance to other multicentre studies. 
      Relationships among subjects' characteristics and among such characteristics and 
      design features may play important roles in the forthcoming analyses on the 
      association between plasma concentrations of POPs and pancreatic cancer risk.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Gasull, Magda
AU  - Gasull M
AD  - Hospital del Mar Institute of Medical Research (IMIM), Barcelona, Catalonia, 
      Spain; Universitat Autonoma de Barcelona, Barcelona, Catalonia, Spain; CIBER de 
      Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain.
FAU - Pumarega, Jose
AU  - Pumarega J
AD  - Hospital del Mar Institute of Medical Research (IMIM), Barcelona, Catalonia, 
      Spain; CIBER de Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain.
FAU - Kiviranta, Hannu
AU  - Kiviranta H
AD  - National Institute for Health and Welfare, Department of Health Security, Kuopio, 
      Finland.
FAU - Rantakokko, Panu
AU  - Rantakokko P
AD  - National Institute for Health and Welfare, Department of Health Security, Kuopio, 
      Finland.
FAU - Raaschou-Nielsen, Ole
AU  - Raaschou-Nielsen O
AD  - Danish Cancer Society Research Center, Copenhagen, Denmark.
FAU - Bergdahl, Ingvar A
AU  - Bergdahl IA
AD  - Department of Biobank Research, Umea University, Umea, Sweden; Occupational and 
      Environmental Medicine, Department of Public Health and Clinical Medicine, Umea 
      University, Umea, Sweden.
FAU - Sandanger, Torkjel Manning
AU  - Sandanger TM
AD  - Department of Community Medicine, UiT-The Arctic University of Norway, Tromso, 
      Norway.
FAU - Goni, Fernando
AU  - Goni F
AD  - CIBER de Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain; Biodonostia 
      Health Research Institute; Public Health Laboratory in Gipuzkoa, Basque 
      Government, San Sebastian, Spain.
FAU - Cirera, Lluis
AU  - Cirera L
AD  - CIBER de Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain; Department of 
      Epidemiology, Murcia Regional Health Council, IMIB - Arrixaca, Murcia, Spain.
FAU - Donat-Vargas, Carolina
AU  - Donat-Vargas C
AD  - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
FAU - Alguacil, Juan
AU  - Alguacil J
AD  - CIBER de Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain; Universidad de 
      Huelva, Huelva, Spain.
FAU - Iglesias, Mar
AU  - Iglesias M
AD  - Department of Pathology, Hospital del Mar (PSMar), Barcelona, Spain.
FAU - Tjonneland, Anne
AU  - Tjonneland A
AD  - Danish Cancer Society Research Center, Copenhagen, Denmark.
FAU - Overvad, Kim
AU  - Overvad K
AD  - Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, 
      Denmark.
FAU - Mancini, Francesca Romana
AU  - Mancini FR
AD  - CESP, Faculte de Medecine - Univ. Paris-Sud, Faculte de Medecine - UVSQ, INSERM, 
      Universite Paris-Saclay, Villejuif, France; Gustave Roussy, Villejuif, France.
FAU - Boutron-Ruault, Marie-Christine
AU  - Boutron-Ruault MC
AD  - CESP, Faculte de Medecine - Univ. Paris-Sud, Faculte de Medecine - UVSQ, INSERM, 
      Universite Paris-Saclay, Villejuif, France; Gustave Roussy, Villejuif, France.
FAU - Severi, Gianluca
AU  - Severi G
AD  - CESP, Faculte de Medecine - Univ. Paris-Sud, Faculte de Medecine - UVSQ, INSERM, 
      Universite Paris-Saclay, Villejuif, France; Gustave Roussy, Villejuif, France.
FAU - Johnson, Theron
AU  - Johnson T
AD  - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 
      Heidelberg, Germany.
FAU - Kuhn, Tilman
AU  - Kuhn T
AD  - Hospital del Mar Institute of Medical Research (IMIM), Barcelona, Catalonia, 
      Spain.
FAU - Trichopoulou, Antonia
AU  - Trichopoulou A
AD  - Hellenic Health Foundation, Athens, Greece.
FAU - Karakatsani, Anna
AU  - Karakatsani A
AD  - Hellenic Health Foundation, Athens, Greece; 2nd Pulmonary Medicine Department, 
      School of Medicine, National and Kapodistrian University of Athens, "ATTIKON" 
      University Hospital, Haidari, Greece.
FAU - Peppa, Eleni
AU  - Peppa E
AD  - Hellenic Health Foundation, Athens, Greece.
FAU - Palli, Domenico
AU  - Palli D
AD  - Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer 
      Research, Prevention and Clinical Network - ISPRO, Florence, Italy.
FAU - Pala, Valeria
AU  - Pala V
AD  - Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 
      Milan, Italy.
FAU - Tumino, Rosario
AU  - Tumino R
AD  - Cancer Registry and Histopathology Department, "Civic - M.P. Arezzo" Hospital, 
      ASP Ragusa, Italy.
FAU - Naccarati, Alessio
AU  - Naccarati A
AD  - Molecular and Genetic Epidemiology Unit, Italian Institute for Genomic Medicine 
      (IIGM), Turin, Italy.
FAU - Panico, Salvatore
AU  - Panico S
AD  - Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, 
      Italy.
FAU - Verschuren, Monique
AU  - Verschuren M
AD  - Centre for Nutrition, Prevention and Health Services, National Institute for 
      Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
FAU - Vermeulen, Roel
AU  - Vermeulen R
AD  - Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The 
      Netherlands.
FAU - Rylander, Charlotta
AU  - Rylander C
AD  - Department of Community Medicine, UiT-The Arctic University of Norway, Tromso, 
      Norway.
FAU - Nost, Therese Haugdahl
AU  - Nost TH
AD  - Department of Community Medicine, UiT-The Arctic University of Norway, Tromso, 
      Norway.
FAU - Rodriguez-Barranco, Miguel
AU  - Rodriguez-Barranco M
AD  - CIBER de Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain; Escuela 
      Andaluza de Salud Publica. Instituto de Investigacion Biosanitaria, Granada, 
      Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain.
FAU - Molinuevo, Amaia
AU  - Molinuevo A
AD  - CIBER de Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain; Biodonostia 
      Health Research Institute; Public Health Laboratory in Gipuzkoa, Basque 
      Government, San Sebastian, Spain.
FAU - Chirlaque, Maria-Dolores
AU  - Chirlaque MD
AD  - CIBER de Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain; Department of 
      Epidemiology, Murcia Regional Health Council, IMIB - Arrixaca, Murcia, Spain; 
      Department of Health and Social Sciences, University of Murcia, Murcia, Spain.
FAU - Ardanaz, Eva
AU  - Ardanaz E
AD  - CIBER de Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain; Navarra Public 
      Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, 
      Pamplona, Spain.
FAU - Sund, Malin
AU  - Sund M
AD  - Department of Surgical and Perioperative Sciences, Umea University, Umea, Sweden.
FAU - Key, Tim
AU  - Key T
AD  - Cancer Epidemiology Unit, Nuffield Department of Population Health, University of 
      Oxford, Oxford, United Kingdom.
FAU - Ye, Weimin
AU  - Ye W
AD  - Department of Biobank Research, Umea University, Umea, Sweden; Department of 
      Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm, Sweden.
FAU - Jenab, Mazda
AU  - Jenab M
AD  - Nutrition and Metabolism Section, International Agency for Research on Cancer 
      (IARC), Lyon, France.
FAU - Michaud, Dominique
AU  - Michaud D
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Imperial 
      College London, London, United Kingdom.
FAU - Matullo, Giuseppe
AU  - Matullo G
AD  - Department Medical Sciences, University of Torino, Italian Institute for Genomic 
      Medicine -IIGM/HuGeF, Torino, Italy.
FAU - Canzian, Federico
AU  - Canzian F
AD  - Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, 
      Germany.
FAU - Kaaks, Rudolf
AU  - Kaaks R
AD  - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 
      Heidelberg, Germany.
FAU - Nieters, Alexandra
AU  - Nieters A
AD  - Center for Chronic Immunodeficiency, Molecular Epidemiology, University Medical 
      Center Freiburg, Freiburg, Germany.
FAU - Nothlings, Ute
AU  - Nothlings U
AD  - Department of Nutrition and Food Sciences, University of Bonn, Bonn, Germany.
FAU - Jeurnink, Suzanne
AU  - Jeurnink S
AD  - Department of Gastroenterology and Hepatology, University Medical Center Utrecht, 
      Utrecht, the Netherlands; National Institute for Public Health and the 
      Environment (RIVM), Bilthoven, the Netherlands.
FAU - Chajes, Veronique
AU  - Chajes V
AD  - Nutrition and Metabolism Section, International Agency for Research on Cancer 
      (IARC), Lyon, France.
FAU - Matejcic, Marco
AU  - Matejcic M
AD  - Nutrition and Metabolism Section, International Agency for Research on Cancer 
      (IARC), Lyon, France.
FAU - Gunter, Marc
AU  - Gunter M
AD  - Nutrition and Metabolism Section, International Agency for Research on Cancer 
      (IARC), Lyon, France.
FAU - Aune, Dagfinn
AU  - Aune D
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Imperial 
      College London, London, United Kingdom.
FAU - Riboli, Elio
AU  - Riboli E
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Imperial 
      College London, London, United Kingdom.
FAU - Agudo, Antoni
AU  - Agudo A
AD  - Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-Idibell), 
      Barcelona, Spain.
FAU - Gonzalez, Carlos Alberto
AU  - Gonzalez CA
AD  - Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-Idibell), 
      Barcelona, Spain.
FAU - Weiderpass, Elisabete
AU  - Weiderpass E
AD  - Department of Community Medicine, UiT-The Arctic University of Norway, Tromso, 
      Norway; Department of Medical Epidemiology and Biostatistics Karolinska 
      Institutet, Stockholm, Sweden; Cancer Registry of Norway, Institute of 
      Population-Based Cancer Research, Oslo, Norway; Genetic Epidemiology Group, 
      Folkhalsan Research Center, Faculty of Medicine, University of Helsinki, 
      Helsinki, Finland.
FAU - Bueno-de-Mesquita, Bas
AU  - Bueno-de-Mesquita B
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Imperial 
      College London, London, United Kingdom; National Institute for Public Health and 
      the Environment (RIVM), Bilthoven, the Netherlands; Department of Social & 
      Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, 
      Malaysia.
FAU - Duell, Eric J
AU  - Duell EJ
AD  - Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-Idibell), 
      Barcelona, Spain.
FAU - Vineis, Paolo
AU  - Vineis P
AD  - Molecular and Genetic Epidemiology Unit, Italian Institute for Genomic Medicine 
      (IIGM), Turin, Italy; Department of Epidemiology and Biostatistics, School of 
      Public Health, Imperial College London, London, United Kingdom.
FAU - Porta, Miquel
AU  - Porta M
AD  - Hospital del Mar Institute of Medical Research (IMIM), Barcelona, Catalonia, 
      Spain; Universitat Autonoma de Barcelona, Barcelona, Catalonia, Spain; CIBER de 
      Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain. Electronic address: 
      mporta@imim.es.
LA  - eng
GR  - 001/WHO_/World Health Organization/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181123
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Case-Control Studies
MH  - Environmental Exposure/*statistics & numerical data
MH  - *Environmental Pollutants
MH  - Gas Chromatography-Mass Spectrometry
MH  - Humans
MH  - Pancreatic Neoplasms/*epidemiology
MH  - Plasma
MH  - Polychlorinated Biphenyls
MH  - Prospective Studies
MH  - Tandem Mass Spectrometry
OTO - NOTNLM
OT  - Biomarkers, methods
OT  - Disease progression bias
OT  - Environmental epidemiology
OT  - Lipids
OT  - Pancreatic cancer
OT  - Persistent organic pollutants
EDAT- 2018/12/12 06:00
MHDA- 2019/12/18 06:00
CRDT- 2018/12/12 06:00
PHST- 2018/09/07 00:00 [received]
PHST- 2018/11/16 00:00 [revised]
PHST- 2018/11/18 00:00 [accepted]
PHST- 2018/12/12 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2018/12/12 06:00 [entrez]
AID - S0013-9351(18)30609-1 [pii]
AID - 10.1016/j.envres.2018.11.027 [doi]
PST - ppublish
SO  - Environ Res. 2019 Feb;169:417-433. doi: 10.1016/j.envres.2018.11.027. Epub 2018 
      Nov 23.