PMID- 30529314
OWN - NLM
STAT- MEDLINE
DCOM- 20190423
LR  - 20190423
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 271
DP  - 2019 Jan
TI  - No correlation between HLA-DQ 2.5, DQ 8.1 and DQ 6.2 and circulating levels of 
      antibodies against gliadins in schizophrenia.
PG  - 325-327
LID - S0165-1781(18)30931-4 [pii]
LID - 10.1016/j.psychres.2018.12.001 [doi]
AB  - It has been suggested that gluten consumption is linked to schizophrenia, with 
      this link strengthened through the presence of circulating anti-native gliadin 
      antibodies (AGAs). The human leukocyte antigen (HLA) system is crucial for 
      antigen presentation and antibody secretion but no study has examined the 
      relationship between HLA-II variants and circulating antibodies against gliadin 
      peptides. In this study, HLA-II variants were genotyped in patients with 
      schizophrenia and the relationship between these variants and plasma AGA levels 
      was examined. Although there was no association found, HLA-AGA associations could 
      potentially serve as a marker of gluten sensitivity in patients with 
      schizophrenia.
CI  - Copyright (c) 2018. Published by Elsevier B.V.
FAU - McLean, Ryan Thomas
AU  - McLean RT
AD  - Institute of Health Research & Innovation, University of the Highlands and 
      Islands, Centre for Health Science, Old Perth Road, Inverness IV2 3JH, UK.
FAU - Halley, Lorna
AU  - Halley L
AD  - Institute of Health Research & Innovation, University of the Highlands and 
      Islands, Centre for Health Science, Old Perth Road, Inverness IV2 3JH, UK.
FAU - Clair, David St
AU  - Clair DS
AD  - Department of Medicine and Dentistry, University of Aberdeen, Aberdeen AB25 2ZD, 
      UK.
FAU - Wei, Jun
AU  - Wei J
AD  - Institute of Health Research & Innovation, University of the Highlands and 
      Islands, Centre for Health Science, Old Perth Road, Inverness IV2 3JH, UK. 
      Electronic address: jun.wei@uhi.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181201
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Antibodies)
RN  - 0 (Biomarkers)
RN  - 0 (HLA-DQ Antigens)
RN  - 9007-90-3 (Gliadin)
SB  - IM
MH  - Adult
MH  - Antibodies/*blood
MH  - Biomarkers
MH  - Female
MH  - Gliadin/*immunology
MH  - HLA-DQ Antigens/*blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Schizophrenia/blood/*immunology
OTO - NOTNLM
OT  - Gluten antibodies
OT  - HLA
OT  - Schizophrenia
EDAT- 2018/12/12 06:00
MHDA- 2019/04/24 06:00
CRDT- 2018/12/12 06:00
PHST- 2018/05/18 00:00 [received]
PHST- 2018/10/24 00:00 [revised]
PHST- 2018/12/01 00:00 [accepted]
PHST- 2018/12/12 06:00 [pubmed]
PHST- 2019/04/24 06:00 [medline]
PHST- 2018/12/12 06:00 [entrez]
AID - S0165-1781(18)30931-4 [pii]
AID - 10.1016/j.psychres.2018.12.001 [doi]
PST - ppublish
SO  - Psychiatry Res. 2019 Jan;271:325-327. doi: 10.1016/j.psychres.2018.12.001. Epub 
      2018 Dec 1.