PMID- 30529369
OWN - NLM
STAT- MEDLINE
DCOM- 20190429
LR  - 20220410
IS  - 1878-3511 (Electronic)
IS  - 1201-9712 (Linking)
VI  - 79
DP  - 2019 Feb
TI  - Paradoxical reaction in HIV-negative tuberculous meningitis patients with spinal 
      involvement.
PG  - 104-108
LID - S1201-9712(18)34945-2 [pii]
LID - 10.1016/j.ijid.2018.11.366 [doi]
AB  - OBJECTIVE: The aim of this study was to investigate the occurrence of paradoxical 
      reaction (PR) in HIV-negative tuberculous meningitis (TBM) patients with spinal 
      involvement, as well as its possible risk factors. METHODS: Fifty TBM patients 
      with spinal involvement were studied retrospectively and divided into a PR group 
      and a non-PR group according to the presence of PR. Their demographic, clinical, 
      radiological, and laboratory data, and status at follow-up were collected and 
      compared. RESULTS: PR developed in 26 patients (52%), with the median time to the 
      development of PR being 30days (range 15-330 days) after the initiation of 
      tuberculosis therapy. At initial diagnosis, age, documented acid-fast bacilli 
      (AFB), and the cerebrospinal fluid protein level were found to differ 
      significantly between the two groups. After multivariate analysis, age, 
      documented AFB, and vertebral involvement were significantly associated with the 
      development of PR. CONCLUSIONS: PR was common in TBM patients with spinal 
      involvement. Age, documented AFB, and musculoskeletal involvement may be 
      predictors of PR development.
CI  - Copyright (c) 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Liu, Yin
AU  - Liu Y
AD  - Department of Radiology, The Third Xiangya Hospital, Central South University, 
      Changsha, Hunan, China.
FAU - Wang, Zheng
AU  - Wang Z
AD  - Department of Neurology, Changsha Central Hospital, Changsha, Hunan, China.
FAU - Yao, Guang
AU  - Yao G
AD  - Department of Neurology, The Third Xiangya Hospital, Central South University, 
      Changsha, Hunan, China.
FAU - Lu, Yuying
AU  - Lu Y
AD  - Department of Neurology, The Third Xiangya Hospital, Central South University, 
      Changsha, Hunan, China.
FAU - Hu, Zhongyang
AU  - Hu Z
AD  - Department of Neurology, The Third Xiangya Hospital, Central South University, 
      Changsha, Hunan, China.
FAU - Yao, Huan
AU  - Yao H
AD  - Department of Neurology, Changsha Central Hospital, Changsha, Hunan, China.
FAU - Zhang, Qinghua
AU  - Zhang Q
AD  - Department of Neurology, The Third Xiangya Hospital, Central South University, 
      Changsha, Hunan, China.
FAU - Zhu, Haixia
AU  - Zhu H
AD  - Department of Neurology, The Third Xiangya Hospital, Central South University, 
      Changsha, Hunan, China.
FAU - Song, Zhi
AU  - Song Z
AD  - Department of Neurology, The Third Xiangya Hospital, Central South University, 
      Changsha, Hunan, China.
FAU - Wang, Wei
AU  - Wang W
AD  - Department of Radiology, The Third Xiangya Hospital, Central South University, 
      Changsha, Hunan, China.
FAU - Liu, Ding
AU  - Liu D
AD  - Department of Neurology, The Third Xiangya Hospital, Central South University, 
      Changsha, Hunan, China. Electronic address: bubu1881@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20181204
PL  - Canada
TA  - Int J Infect Dis
JT  - International journal of infectious diseases : IJID : official publication of the 
      International Society for Infectious Diseases
JID - 9610933
RN  - 0 (Cerebrospinal Fluid Proteins)
SB  - IM
MH  - Adult
MH  - Bacillus/isolation & purification
MH  - Cerebrospinal Fluid/microbiology
MH  - Cerebrospinal Fluid Proteins
MH  - Female
MH  - Follow-Up Studies
MH  - HIV Infections
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Spinal Cord/*microbiology
MH  - Tuberculosis, Meningeal/*diagnosis/*therapy
MH  - Young Adult
OTO - NOTNLM
OT  - Cerebrospinal fluid
OT  - Paradoxical reaction
OT  - Spinal
OT  - Tuberculous meningitis
EDAT- 2018/12/12 06:00
MHDA- 2019/04/30 06:00
CRDT- 2018/12/12 06:00
PHST- 2018/08/10 00:00 [received]
PHST- 2018/11/26 00:00 [revised]
PHST- 2018/11/27 00:00 [accepted]
PHST- 2018/12/12 06:00 [pubmed]
PHST- 2019/04/30 06:00 [medline]
PHST- 2018/12/12 06:00 [entrez]
AID - S1201-9712(18)34945-2 [pii]
AID - 10.1016/j.ijid.2018.11.366 [doi]
PST - ppublish
SO  - Int J Infect Dis. 2019 Feb;79:104-108. doi: 10.1016/j.ijid.2018.11.366. Epub 2018 
      Dec 4.