PMID- 30529874
OWN - NLM
STAT- MEDLINE
DCOM- 20190415
LR  - 20191210
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 271
DP  - 2019 Jan
TI  - Early recovery and employment outcome 13 years after first episode psychosis.
PG  - 374-380
LID - S0165-1781(18)32008-0 [pii]
LID - 10.1016/j.psychres.2018.12.013 [doi]
AB  - 175 cases of first episode psychosis were recruited to the Parachute project in 
      1996-97. The program offered highly available and continuous psychosocial support 
      and a cautious use of antipsychotic medication for 5 years from inclusion. 
      Outcome-data for year 13 after inclusion, were retrieved from Swedish population 
      registries on 161 of the original cases. During the first year after inclusion 
      the cohort improved in the scores of the Brief Psychiatric Rating Scale (BPRS) 
      and Global Assessment of Function (GAF) to median levels that later remained 
      rather stable. By month 12 the median GAF score was 65. 68% of the cases were in 
      remission from psychotic symptoms as assessed with BPRS. 38% of the cases in 
      remission and 60% not in remission had prescriptions of antipsychotic medication 
      by month 12. By year 13 after inclusion, 42% were in employment and 55% had any 
      dispensation of antipsychotic medication. 70% of the cases with employment had no 
      dispensations of antipsychotic medication. In conclusion, Many first episode 
      psychosis cases that were offered extensive psychosocial support and cautious use 
      of antipsychotic medication had good early recovery and good late employment 
      outcome.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Stralin, Pontus
AU  - Stralin P
AD  - Department of clinical neuroscience, Karolinska institute, Stockholm, Sweden. 
      Electronic address: pontus.stralin@sll.se.
FAU - Skott, Maria
AU  - Skott M
AD  - Department of clinical neuroscience, Karolinska institute, Stockholm, Sweden.
FAU - Cullberg, Johan
AU  - Cullberg J
AD  - Department of medicine, Karolinska institute, Stockholm, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181203
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antipsychotic Agents/*therapeutic use
MH  - Cohort Studies
MH  - Employment/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Outcome Assessment, Health Care/*statistics & numerical data
MH  - Psychotic Disorders/drug therapy/*epidemiology/*therapy
MH  - Registries/*statistics & numerical data
MH  - Sweden
MH  - Young Adult
OTO - NOTNLM
OT  - Abbreviations: BPRS, Brief Psychiatric Rating Scale
OT  - Antipsychotics
OT  - DDD, defined daily doses
OT  - Early intervention
OT  - FEP, first episode psychosis
OT  - GAF, Global Assessment of Function
OT  - Psychoses
OT  - SC, Strauss-Carpenter Outcome Scale
OT  - SEK, Swedish kronor
OT  - Schizophrenia
EDAT- 2018/12/12 06:00
MHDA- 2019/04/16 06:00
CRDT- 2018/12/12 06:00
PHST- 2018/10/31 00:00 [received]
PHST- 2018/12/02 00:00 [revised]
PHST- 2018/12/03 00:00 [accepted]
PHST- 2018/12/12 06:00 [pubmed]
PHST- 2019/04/16 06:00 [medline]
PHST- 2018/12/12 06:00 [entrez]
AID - S0165-1781(18)32008-0 [pii]
AID - 10.1016/j.psychres.2018.12.013 [doi]
PST - ppublish
SO  - Psychiatry Res. 2019 Jan;271:374-380. doi: 10.1016/j.psychres.2018.12.013. Epub 
      2018 Dec 3.