PMID- 30530140
OWN - NLM
STAT- MEDLINE
DCOM- 20190221
LR  - 20190221
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 656
DP  - 2019 Mar 15
TI  - Body burden of organohalogenated pollutants and polycyclic aromatic hydrocarbons 
      in Romanian population: Influence of age, gender, body mass index, and habitat.
PG  - 709-716
LID - S0048-9697(18)34759-4 [pii]
LID - 10.1016/j.scitotenv.2018.11.404 [doi]
AB  - Persistent organochlorine pollutants (POPs) are highly lipophilic and resistant 
      to degradation, hence these substances are commonly found in the environment even 
      decades after their prohibition. The aim of the present study was to determine 
      human serum concentrations of POPs and polycyclic aromatic hydrocarbons (PAHs) in 
      the Romanian population, investigating the role of demographic variables on the 
      body burden of such chemicals. A cross-sectional study including a total of 121 
      subjects from Brasov (Transylvania region) was designed. The concentration of 62 
      chemicals, including organochlorine pesticides (OCPs), polychlorinated biphenyls 
      (PCBs), polybrominated diphenyl ethers (BDEs) and PAHs, was measured by gas 
      chromatography-mass spectrometry (GC-MS) in the serum of the participants. 
      p,p'-DDE and beta-HCH were detected in 100% and 62% of the series (median 
      values = 2.1 and 0.5 mug/L); PCB-153 was detected in 77.7% of the subjects and 
      PCB-28 showed the highest median concentration (0.5 mug/L); BDE-47 was detected at 
      a low concentration in 11.6% of the individuals; phenanthrene and naphthalene 
      were present in 98.3% and 38.8% of the serum samples (median values = 0.9 and 
      6.5 mug/L, respectively). Age was the main determinant of the total body burden of 
      OCPs and PCBs. A positive correlation was observed between p,p'-DDE and age 
      (Spearman Rho = 0.312, P < 0.0001), suggesting the prevalence of higher levels of 
      pollutants at older ages. The present results showed a significant decrease in 
      serum levels of p,p'-DDE and HCH in Romania -a country which has traditionally 
      reported higher values than other Eastern European countries- as well as low 
      levels of PCBs and BDEs. The presence of PAHs suggests an unknown source of 
      exposure that deserves further investigation.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Luzardo, Octavio P
AU  - Luzardo OP
AD  - Toxicology Unit, Research Institute of Biomedical and Health Sciences (IUIBS), 
      Instituto Canario de Investigacion del Cancer (ICIC), Universidad de Las Palmas 
      de Gran Canaria, Paseo Blas Cabrera s/n, 35016 Las Palmas de Gran Canaria, Spain; 
      Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition 
      (CIBERObn), Paseo Blas Cabrera Felipe s/n, 35016 Las Palmas, Spain. Electronic 
      address: octavio.perez@ulpgc.es.
FAU - Badea, Mihaela
AU  - Badea M
AD  - Faculty of Medicine, Transilvania University of Brasov, Nicolae Balcescu 56, 
      500019, Brasov, Romania. Electronic address: mihaela.badea@unitbv.ro.
FAU - Zumbado, Manuel
AU  - Zumbado M
AD  - Toxicology Unit, Research Institute of Biomedical and Health Sciences (IUIBS), 
      Instituto Canario de Investigacion del Cancer (ICIC), Universidad de Las Palmas 
      de Gran Canaria, Paseo Blas Cabrera s/n, 35016 Las Palmas de Gran Canaria, Spain. 
      Electronic address: manuel.zumbado@ulpgc.es.
FAU - Rogozea, Liliana
AU  - Rogozea L
AD  - Faculty of Medicine, Transilvania University of Brasov, Nicolae Balcescu 56, 
      500019, Brasov, Romania. Electronic address: r_liliana@unitbv.ro.
FAU - Floroian, Laura
AU  - Floroian L
AD  - Faculty of Electrical Engineering and Computer Sciences, Transilvania University 
      of Brasov, Bdul Eroilor 29, 500039, Brasov, Romania. Electronic address: 
      lauraf@unitbv.ro.
FAU - Ilea, Anca
AU  - Ilea A
AD  - Faculty of Medicine, Transilvania University of Brasov, Nicolae Balcescu 56, 
      500019, Brasov, Romania.
FAU - Moga, Marius
AU  - Moga M
AD  - Faculty of Medicine, Transilvania University of Brasov, Nicolae Balcescu 56, 
      500019, Brasov, Romania. Electronic address: mogas@unitbv.ro.
FAU - Sechel, Gabriela
AU  - Sechel G
AD  - Faculty of Medicine, Transilvania University of Brasov, Nicolae Balcescu 56, 
      500019, Brasov, Romania.
FAU - Boada, Luis D
AU  - Boada LD
AD  - Toxicology Unit, Research Institute of Biomedical and Health Sciences (IUIBS), 
      Instituto Canario de Investigacion del Cancer (ICIC), Universidad de Las Palmas 
      de Gran Canaria, Paseo Blas Cabrera s/n, 35016 Las Palmas de Gran Canaria, Spain; 
      Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition 
      (CIBERObn), Paseo Blas Cabrera Felipe s/n, 35016 Las Palmas, Spain. Electronic 
      address: luis.boada@ulpgc.es.
FAU - Henriquez-Hernandez, Luis Alberto
AU  - Henriquez-Hernandez LA
AD  - Toxicology Unit, Research Institute of Biomedical and Health Sciences (IUIBS), 
      Instituto Canario de Investigacion del Cancer (ICIC), Universidad de Las Palmas 
      de Gran Canaria, Paseo Blas Cabrera s/n, 35016 Las Palmas de Gran Canaria, Spain. 
      Electronic address: luis.henriquez@ulpgc.es.
LA  - eng
PT  - Journal Article
DEP - 20181129
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Body Mass Index
MH  - Cross-Sectional Studies
MH  - *Environmental Exposure
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Halogenated Diphenyl Ethers/*blood
MH  - Humans
MH  - Hydrocarbons, Chlorinated/blood
MH  - Male
MH  - Middle Aged
MH  - Pesticides/*blood
MH  - Polychlorinated Biphenyls/*blood
MH  - Polycyclic Aromatic Hydrocarbons/*blood
MH  - Residence Characteristics
MH  - Romania
MH  - Sex Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Human serum
OT  - Organochlorine pesticides
OT  - Polybrominated diphenyl ethers
OT  - Polychlorinated biphenyls
OT  - Polycyclic aromatic hydrocarbons
OT  - Romania
EDAT- 2018/12/12 06:00
MHDA- 2019/02/23 06:00
CRDT- 2018/12/12 06:00
PHST- 2018/09/27 00:00 [received]
PHST- 2018/11/04 00:00 [revised]
PHST- 2018/11/26 00:00 [accepted]
PHST- 2018/12/12 06:00 [pubmed]
PHST- 2019/02/23 06:00 [medline]
PHST- 2018/12/12 06:00 [entrez]
AID - S0048-9697(18)34759-4 [pii]
AID - 10.1016/j.scitotenv.2018.11.404 [doi]
PST - ppublish
SO  - Sci Total Environ. 2019 Mar 15;656:709-716. doi: 10.1016/j.scitotenv.2018.11.404. 
      Epub 2018 Nov 29.