PMID- 30530165
OWN - NLM
STAT- MEDLINE
DCOM- 20190503
LR  - 20190503
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 67
DP  - 2019 Feb
TI  - Antidepressant effect of helicid in chronic unpredictable mild stress model in 
      rats.
PG  - 13-21
LID - S1567-5769(18)31246-3 [pii]
LID - 10.1016/j.intimp.2018.11.052 [doi]
AB  - Helicid (4-formylphenyl-beta-D-allopyranoside) is a bioactive constituent of Helicid 
      nilgirica Bedd that has been used in Chinese traditional herbal medicine to treat 
      headache, insomnia, and depression. However, the underlying mechanisms of these 
      effects are unclear. We have now investigated the effect of helicid on 
      depression-related behaviors in rats exposed to chronic unpredictable mild stress 
      (CUMS) and have also explored possible underlying mechanisms that involve 
      neurotrophin expression. After 6 weeks isolation, body weight and sucrose 
      preference were significantly reduced in rats with CUMS-induced depression 
      compared with controls. The CUMS rats also showed significant inhibition of 
      locomotory parameters in open field tests (involving behavioral assays). Helicid 
      significantly regulated levels of corticosterone (CORT), inflammatory cytokines 
      and 5-hydroxytryptamine (5-HT). Helicid also reversed CUMS-induced decreases of 
      5-HT1A receptor expression and promoted brain derived neurotrophic factor (BDNF) 
      expression in the hippocampus The significant reversal of depressive-like 
      behaviors by helicid is similar to that achieved by fluoxetine. The 
      antidepressive effects are likely attributable to the promotion of hippocampal 
      neurotrophin expression through activation of the serotonergic system. Helicid 
      thus has potential for treating depressive disorders.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Tong, Jiucui
AU  - Tong J
AD  - Provincial Key Lab. of the Conservation and Exploitation Research of Biological 
      Resources in Anhui, Life Science College of Anhui Normal University, Wuhu, Anhui 
      241000, China; Department of Clinical Pharmacy, Yijishan Hospital of Wannan 
      Medical College, Anhui Provincial Center for Drug Clinical Evaluation, Wuhu, 
      Anhui 241001, China.
FAU - Zhou, Zhiming
AU  - Zhou Z
AD  - Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 
      241001, China.
FAU - Qi, Weiwei
AU  - Qi W
AD  - Wannan Medical College, Wuhu, Anhui 241001, China.
FAU - Jiang, Siyan
AU  - Jiang S
AD  - Department of Clinical Pharmacy, Yijishan Hospital of Wannan Medical College, 
      Anhui Provincial Center for Drug Clinical Evaluation, Wuhu, Anhui 241001, China.
FAU - Yang, Bin
AU  - Yang B
AD  - Department of Clinical Pharmacy, Yijishan Hospital of Wannan Medical College, 
      Anhui Provincial Center for Drug Clinical Evaluation, Wuhu, Anhui 241001, China.
FAU - Zhong, Zhengling
AU  - Zhong Z
AD  - Department of Clinical Pharmacy, Yijishan Hospital of Wannan Medical College, 
      Anhui Provincial Center for Drug Clinical Evaluation, Wuhu, Anhui 241001, China.
FAU - Jia, Yuanwei
AU  - Jia Y
AD  - Department of Clinical Pharmacy, Yijishan Hospital of Wannan Medical College, 
      Anhui Provincial Center for Drug Clinical Evaluation, Wuhu, Anhui 241001, China.
FAU - Li, Xuyi
AU  - Li X
AD  - Wannan Medical College, Wuhu, Anhui 241001, China.
FAU - Xiong, Lei
AU  - Xiong L
AD  - Provincial Key Lab. of the Conservation and Exploitation Research of Biological 
      Resources in Anhui, Life Science College of Anhui Normal University, Wuhu, Anhui 
      241000, China; Wannan Medical College, Wuhu, Anhui 241001, China.
FAU - Nie, Liuwang
AU  - Nie L
AD  - Provincial Key Lab. of the Conservation and Exploitation Research of Biological 
      Resources in Anhui, Life Science College of Anhui Normal University, Wuhu, Anhui 
      241000, China. Electronic address: lwnie@mail.ahnu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20181206
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Antidepressive Agents)
RN  - 0 (Benzaldehydes)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 112692-38-3 (Receptor, Serotonin, 5-HT1A)
RN  - 333DO1RDJY (Serotonin)
RN  - 80154-34-3 (helicide)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*therapeutic use
MH  - Benzaldehydes/*therapeutic use
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Corticosterone/metabolism
MH  - Depression/*drug therapy
MH  - Disease Models, Animal
MH  - Hippocampus/*metabolism
MH  - Humans
MH  - Male
MH  - Medicine, Chinese Traditional
MH  - Motor Activity/drug effects
MH  - Nerve Growth Factors/*metabolism
MH  - Proteaceae/immunology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, Serotonin, 5-HT1A/metabolism
MH  - Serotonin/metabolism
OTO - NOTNLM
OT  - Antidepressant
OT  - Chronic unpredictable mild stress
OT  - Helicid
OT  - Inflammatory cytokine
OT  - Serotonergic system
EDAT- 2018/12/12 06:00
MHDA- 2019/05/06 06:00
CRDT- 2018/12/12 06:00
PHST- 2018/08/05 00:00 [received]
PHST- 2018/11/26 00:00 [revised]
PHST- 2018/11/28 00:00 [accepted]
PHST- 2018/12/12 06:00 [pubmed]
PHST- 2019/05/06 06:00 [medline]
PHST- 2018/12/12 06:00 [entrez]
AID - S1567-5769(18)31246-3 [pii]
AID - 10.1016/j.intimp.2018.11.052 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2019 Feb;67:13-21. doi: 10.1016/j.intimp.2018.11.052. Epub 
      2018 Dec 6.