PMID- 30533246 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 2093-985X (Electronic) IS - 2093-9868 (Print) IS - 2093-9868 (Linking) VI - 8 IP - 2 DP - 2018 May TI - Multimodal Intravascular Photoacoustic and Ultrasound Imaging. PG - 193-201 LID - 10.1007/s13534-018-0061-8 [doi] AB - The rupture of atherosclerotic plaques is the leading cause of death in developed countries. Early identification of vulnerable plaque is the essential step in preventing acute coronary events. Intravascular photoacoustic (IVPA) technology is able to visualize chemical composition of atherosclerotic plaque with high specificity and sensitivity. Integrated with intravascular ultrasound (IVUS) imaging, this multimodal intravascular IVPA/IVUS imaging technology is able to provide both structural and chemical compositions of arterial walls for detecting and characterizing atherosclerotic plaques. In this paper, we present representative multimodal IVPA/IVUS imaging systems and discuss current scientific innovations, potential limitations, and prospective improvements for characterization of coronary atherosclerosis. FAU - Li, Yan AU - Li Y AD - Beckman Laser Institute, University of California, Irvine, 1002 Health Sciences Road, Irvine, CA 92617 USA. FAU - Chen, Zhongping AU - Chen Z AD - Beckman Laser Institute, University of California, Irvine, 1002 Health Sciences Road, Irvine, CA 92617 USA. AD - Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697-2700 USA. LA - eng GR - P41 EB015890/EB/NIBIB NIH HHS/United States GR - R01 HL127271/HL/NHLBI NIH HHS/United States GR - R01 HL125084/HL/NHLBI NIH HHS/United States GR - R01 EY021529/EY/NEI NIH HHS/United States GR - R01 EY026091/EY/NEI NIH HHS/United States PT - Journal Article DEP - 20180326 PL - Germany TA - Biomed Eng Lett JT - Biomedical engineering letters JID - 101567784 PMC - PMC6208523 MID - NIHMS986618 OTO - NOTNLM OT - atherosclerosis OT - imaging probe OT - intravascular imaging OT - multimodal OT - photoacoustic OT - ultrasound COIS- Conflict of interest Dr. Zhongping Chen has a financial interest in OCT Medical Imaging, Inc., which, however, did not support this work. EDAT- 2018/12/12 06:00 MHDA- 2018/12/12 06:01 PMCR- 2019/03/26 CRDT- 2018/12/12 06:00 PHST- 2018/12/12 06:00 [entrez] PHST- 2018/12/12 06:00 [pubmed] PHST- 2018/12/12 06:01 [medline] PHST- 2019/03/26 00:00 [pmc-release] AID - 61 [pii] AID - 10.1007/s13534-018-0061-8 [doi] PST - ppublish SO - Biomed Eng Lett. 2018 May;8(2):193-201. doi: 10.1007/s13534-018-0061-8. Epub 2018 Mar 26.