PMID- 30534092 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 9 DP - 2018 TI - Differences in Neural Recovery From Acute Stress Between Cortisol Responders and Non-responders. PG - 631 LID - 10.3389/fpsyt.2018.00631 [doi] LID - 631 AB - Adaptive recovery from a stressor fosters resilience. So far, however, few studies have examined brain functional connectivity in the aftermath of stress, with inconsistent results reported. Focusing on the immediate recovery from psychosocial stress, the current study compared amygdala resting-state functional connectivity (RSFC) before and immediately after psychosocial stress between cortisol responders and non-responders. Differences between groups were expected for amygdala RSFC with regions involved in down-regulation of the physiological stress response, emotion regulation, and memory consolidation. Eighty-six healthy participants (36 males/50 females) underwent a social stress paradigm inside the MRI scanner. Before and immediately after stress, resting-state (RS) fMRI scans were acquired to determine amygdala RSFC. Next, changes in connectivity from pre- to post-stress were compared between cortisol responders and non-responders. Responders demonstrated a cortisol increase, higher negative affect, and decreased heart rate variability (HRV) in response to stress compared to non-responders. A significant Sex-by-Responder-by-Time interaction was found between the bilateral amygdala and posterior cingulate cortex (PCC) and precuneus (p < 0.05, corrected). As males were also more likely to show a cortisol increase to the stress task than females, follow-up analyses were conducted for both sexes separately. Whereas no difference was observed between female responders and non-responders, male non-responders showed an increase in FC after stress between the bilateral amygdala and the PCC and precuneus (p < 0.05, corrected). The increased coupling of the amygdala with the PCC/precuneus, a core component of the default mode network (DMN), might indicate an increased engagement of the amygdala within the DMN directly after stress in non-responders. Although this study was carried out in healthy participants, and the results likely reflect normal variations in the neural response to stress, understanding the mechanisms that underlie these variations could prove beneficial in revealing neural markers that promote resilience to stress-related disorders. FAU - Dimitrov, Annika AU - Dimitrov A AD - Research Division of Mind and Brain, Department of Psychiatry and Psychotherapy CCM, Charite-Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Berlin, Germany. AD - Mood Disorders Research Group, Department of Psychiatry and Psychotherapy CCM, Charite-Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Berlin, Germany. FAU - Demin, Katharina AU - Demin K AD - Research Division of Mind and Brain, Department of Psychiatry and Psychotherapy CCM, Charite-Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Berlin, Germany. AD - Department of Epileptology, Epilepsy-Center Berlin-Brandenburg, Evangelisches Krankenhaus Konigin Elisabeth Herzberge, Berlin, Germany. FAU - Fehlner, Phobe AU - Fehlner P AD - Research Division of Mind and Brain, Department of Psychiatry and Psychotherapy CCM, Charite-Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Berlin, Germany. AD - Division of Systems Neuroscience in Psychiatry, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. FAU - Walter, Henrik AU - Walter H AD - Research Division of Mind and Brain, Department of Psychiatry and Psychotherapy CCM, Charite-Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Berlin, Germany. FAU - Erk, Susanne AU - Erk S AD - Research Division of Mind and Brain, Department of Psychiatry and Psychotherapy CCM, Charite-Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Berlin, Germany. FAU - Veer, Ilya M AU - Veer IM AD - Research Division of Mind and Brain, Department of Psychiatry and Psychotherapy CCM, Charite-Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Berlin, Germany. LA - eng PT - Journal Article DEP - 20181126 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC6275218 OTO - NOTNLM OT - amygdala OT - cortisol OT - fMRI OT - functional connectivity OT - resting state OT - stress recovery EDAT- 2018/12/12 06:00 MHDA- 2018/12/12 06:01 PMCR- 2018/11/26 CRDT- 2018/12/12 06:00 PHST- 2018/03/15 00:00 [received] PHST- 2018/11/07 00:00 [accepted] PHST- 2018/12/12 06:00 [entrez] PHST- 2018/12/12 06:00 [pubmed] PHST- 2018/12/12 06:01 [medline] PHST- 2018/11/26 00:00 [pmc-release] AID - 10.3389/fpsyt.2018.00631 [doi] PST - epublish SO - Front Psychiatry. 2018 Nov 26;9:631. doi: 10.3389/fpsyt.2018.00631. eCollection 2018.