PMID- 30534210
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1878-5409 (Electronic)
IS  - 1878-5409 (Linking)
VI  - 10
IP  - 1
DP  - 2014 Jul
TI  - Striking improvement in a case of reduced ejection fraction heart failure with 
      baroreflex activation therapy.
PG  - 4-6
LID - 10.1016/j.jccase.2014.02.007 [doi]
AB  - A patient experiencing chronic New York Heart Association (NYHA) Class III heart 
      failure with reduced left ventricular ejection fraction and signs of right 
      ventricular dysfunction is treated with baroreflex activation therapy (BAT). 
      Despite optimal medical therapy, the patient had repeatedly decompensated and was 
      approaching a refractory terminal stage. BAT chronically reduced muscle 
      sympathetic nerve activity and dramatically improved clinical presentation of the 
      patient to NYHA Class I through 12 months of therapy. BAT may hold promise for 
      patients with advanced heart failure and reduced ejection fraction who have 
      exhausted conventional therapy options. <Learning objective: Activation of the 
      baroreflex via stimulation of the carotid sinus acutely improves hemodynamics and 
      chronically improves the clinical course of a patient with heart failure and 
      reduced ejection fraction. The patient transitions from near end-stage New York 
      Heart Association Class III to Class I at 12 months of therapy. The baroreflex 
      pathway may be a viable option for treatment of heart failure patients.>.
FAU - Gronda, Edoardo
AU  - Gronda E
AD  - Cardiovascular Department, IRCCS MultiMedica, Sesto San Giovanni, Milan, Italy.
FAU - Brambilla, Gianmaria
AU  - Brambilla G
AD  - Clinica Medica, Dipartimento di Medicina Clinica e Prevenzione, Universita 
      Milano-Bicocca, Milan, Italy.
FAU - Lovett, Eric G
AU  - Lovett EG
AD  - CVRx, Inc., Minneapolis, MN, USA.
FAU - Costantino, Giuseppe
AU  - Costantino G
AD  - Cardiovascular Department, IRCCS MultiMedica, Sesto San Giovanni, Milan, Italy.
FAU - Georgakpoulos, Dimitrios
AU  - Georgakpoulos D
AD  - CVRx, Inc., Minneapolis, MN, USA.
FAU - Vanoli, Emilio
AU  - Vanoli E
AD  - Cardiovascular Department, IRCCS MultiMedica, Sesto San Giovanni, Milan, Italy.
AD  - Dipartimento di Medicina Molecolare, Universita di Pavia, Pavia, Italy.
LA  - eng
PT  - Case Reports
DEP - 20140328
PL  - Japan
TA  - J Cardiol Cases
JT  - Journal of cardiology cases
JID - 101549579
PMC - PMC6278669
OTO - NOTNLM
OT  - Autonomic nervous system
OT  - Baroreflex
OT  - Heart failure
OT  - Non-pharmacologic therapy
EDAT- 2014/03/28 00:00
MHDA- 2014/03/28 00:01
PMCR- 2014/03/28
CRDT- 2018/12/12 06:00
PHST- 2013/12/09 00:00 [received]
PHST- 2014/02/03 00:00 [revised]
PHST- 2014/02/27 00:00 [accepted]
PHST- 2018/12/12 06:00 [entrez]
PHST- 2014/03/28 00:00 [pubmed]
PHST- 2014/03/28 00:01 [medline]
PHST- 2014/03/28 00:00 [pmc-release]
AID - S1878-5409(14)00033-4 [pii]
AID - 10.1016/j.jccase.2014.02.007 [doi]
PST - epublish
SO  - J Cardiol Cases. 2014 Mar 28;10(1):4-6. doi: 10.1016/j.jccase.2014.02.007. 
      eCollection 2014 Jul.