PMID- 30536018
OWN - NLM
STAT- MEDLINE
DCOM- 20200319
LR  - 20210109
IS  - 1708-0428 (Electronic)
IS  - 0960-8923 (Linking)
VI  - 29
IP  - 3
DP  - 2019 Mar
TI  - Effect of Laparoscopic Sleeve Gastrectomy on Type 2 Diabetes Mellitus in Patients 
      with Body Mass Index less than 30 kg/m(2).
PG  - 835-842
LID - 10.1007/s11695-018-3602-4 [doi]
AB  - BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) has been proved to be the most 
      effective treatment strategy for the treatment of type 2 diabetes mellitus (T2DM) 
      with a body mass index >/= 30 kg/m(2) achieving high remission rates. However, 
      there are few clinical studies on the treatment of T2DM patients with a body mass 
      index less than 30 kg/m(2) by LSG. This study aims to study the effect of LSG on 
      type 2 diabetes mellitus(T2DM) in patients with a body mass index (BMI) less than 
      30 kg/m(2). METHODS: The clinical data of 25 patients with type 2 diabetes 
      mellitus (T2DM) and body mass index 23.23-29.97 kg/m(2) who were treated by LSG 
      at the Department of Bariatric and Metabolic Surgery in China-Japan Union 
      Hospital of Jilin University from May 2016 to May 2017 were retrospectively 
      analyzed. The changes of fasting plasma glucose, glycosylated hemoglobin, insulin 
      resistance index, body weight, body mass index, waist circumference, blood 
      pressure, heart rate, blood lipids, and uric acid were analyzed at 3 months, 
      6 months, and 12 months after operation, respectively. All the clinical data were 
      analyzed by SPSS 22.0. They were tested with a single-sample K-S test to 
      determine whether they were normal distribution data. The normal distribution 
      data were analyzed by a matched t test, and the Mann-Whitney test was used to 
      examine skewed data. RESULTS: All patients (9 males, 16 females) with a median 
      age of 57(24~65) years were treated successfully by laparoscopic sleeve 
      gastrectomy. The median duration of type 2 diabetes mellitus was 10(0~20)years. 
      The preoperative fasting plasma glucose, glycosylated hemoglobin, body weight, 
      body mass index, and waist circumference were 
      10.32 +/- 2.66 mmol/L,8.20 +/- 1.47%,76.54 +/- 10.02 kg,27.92 +/- 1.72 kg/m(2), and 
      99.88 +/- 5.38 cm, respectively. The meaning fasting plasma glucose was 
      7.26 +/- 1.36 mmol/L, 6.90 +/- 1.07 mmol/L, and 6.62 +/- 0.97 mmol/L, respectively, at 
      3, 6, and 12 months after operation. The mean HbAlc in the same observation 
      intervals was 6.88 +/- 1.23%,6.54 +/- 1.02%, and 6.51 +/- 0.89%, respectively. The body 
      weight was 62.18 +/- 8.38 kg,59.07 +/- 8.58 kg, and 58.62 +/- 8.53 kg, respectively. 
      The corresponding body mass index was 22.56 +/- 1.56 kg/m(2), 21.35 +/- 1.58 kg/m(2), 
      and 21.24 +/- 1.86 kg/m(2), respectively. The waist circumference was 
      82.84 +/- 5.10 cm,78.60 +/- 5.21 cm, and 76.92 +/- 5.21 cm, respectively. The complete 
      remission rates of type 2 diabetes mellitus were 40%, 60%, and 68%, respectively, 
      at 3, 6, and 12 months after operation. The complete remission rates for insulin 
      resistance index were 52.4%, 80%, and 80%, postoperatively, at 3, 6, and 
      12 months, respectively. The complete remission rates of hypertension were 22.2%, 
      50%, and 75%,respectively, at 3,6, and 12 months after operation. The complete 
      remission rates of hypertriglyceridemia were 66.7%, 66.7%, and 100%,and the 
      complete remission rates of hypercholesterolemia were 41.7%, 60%, and 100%;the 
      abnormal elevations of plasma cholesterol in two patients with normal cholesterol 
      before operation were significantly higher, postoperatively, at 3 monthsand 
      6 months, respectively. The complete remission rates of hyperuricemia were 37.5%, 
      33.3%, and 100% in the same observation period, respectively. The abnormal 
      elevations of uric acid in two patients with normal uricemia before operation 
      were significantly higher at postoperative 3 months. CONCLUSION: LSG has a 
      significant effect on patients with type 2 diabetes mellitus whose BMI less than 
      30 kg/m(2) in a short time, but its long-term effectiveness needs to be further 
      followed up.
FAU - Wang, Lun
AU  - Wang L
AD  - Department of Bariatric and Metabolic Surgery, China-Japan Union Hospital, Jilin 
      University, Changchun, 130033, China.
FAU - Wang, Jinfa
AU  - Wang J
AD  - Department of Bariatric and Metabolic Surgery, China-Japan Union Hospital, Jilin 
      University, Changchun, 130033, China.
FAU - Jiang, Tao
AU  - Jiang T
AUID- ORCID: 0000-0001-8835-2905
AD  - Department of Bariatric and Metabolic Surgery, China-Japan Union Hospital, Jilin 
      University, Changchun, 130033, China. jt214069@263.net.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Obes Surg
JT  - Obesity surgery
JID - 9106714
SB  - IM
MH  - Adult
MH  - Aged
MH  - Body Mass Index
MH  - *Diabetes Mellitus, Type 2/complications/physiopathology/surgery
MH  - Female
MH  - *Gastrectomy
MH  - Humans
MH  - *Laparoscopy
MH  - Male
MH  - Middle Aged
MH  - Overweight/*complications
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Body mass index
OT  - Laparoscopy
OT  - Sleeve gastrectomy
OT  - Type 2 diabetes mellitus
EDAT- 2018/12/12 06:00
MHDA- 2020/03/20 06:00
CRDT- 2018/12/12 06:00
PHST- 2018/12/12 06:00 [pubmed]
PHST- 2020/03/20 06:00 [medline]
PHST- 2018/12/12 06:00 [entrez]
AID - 10.1007/s11695-018-3602-4 [pii]
AID - 10.1007/s11695-018-3602-4 [doi]
PST - ppublish
SO  - Obes Surg. 2019 Mar;29(3):835-842. doi: 10.1007/s11695-018-3602-4.